Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary hypothyroidism was found to be the cause of hyperlipidemia in 22 patients. The mean age was 46 years, 59% were males, 27% had vascular disease, 14% had xanthomas and 86% had thyroid antibodies. Familial involvement was shown in 3 propositi. All patients were treated with L-thyroxine, 0.05--0.2 mg/day for a mean of 16 months. Combined hyperlipidemia was common (77%), and lipoprotein phenotyping revealed types IIB hyperlipopro-teinemia in 11, IIA in 5, III in 3 and IV in 3 patients. With treatment, normal plasma cholesterol (less than 265 mg/dl) and triglycerides (less than 200 mg/dl) were obtained in 91% and 86%, respectively. The mean maintenance L-thyroxine dose was 0.15 mg/day, but smaller doses often showed marked hypolipidemic effect. The mean +/- S. D. pretreatment fasting plasma cholesterol and triglycerides were 387 +/- 120 and 328 +/-247 mg/dl and on thyroid treatment the mean minimum levels were 205 +/- 46 and 133 +/- 65 mg/dl, respectively (both p values less than 0.005). Hypothyroidism has proved to be a common reversible form of hyperlipidemia. One cardiac patient died and three others had to have their L-thyroxine titrated to prevent angina. Family screening has been of use in case finding for auto-immune disease in 3 families.
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PMID:Hypothyroidism, an important cause of reversible hyperlipidemia. 83 19

Coronary artery bypass grafting (CABG) for patients with ischemic heart disease and hypothyroidism contains many controversies, such as a need of preoperative thyroid replacement therapy and the influences on thyroid function and hemodynamics. A 73-year-old man with three vessel disease including left main trunk lesion was admitted for CABG. Primary hypothyroidism was diagnosed after admission because of high CPK value. The CABG was performed safely with preoperative minimal thyroid replacement and his postoperative course was uneventful. We evaluated the change of perioperative thyroid hormones. At the start of the extracorporeal (ECC), values of T3 and free-T3 decreased progressively, but the change was small. On the other hand, values of T4 and free-T4 increased after the start of ECC. It is suggested that CABG for a patient with angina and hypothyroidism can be performed safely with minimal preoperative thyroid replacement therapy.
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PMID:[A case report on successful coronary artery bypass grafting (CABG) for angina pectoris combined with hypothyroidism]. 909 85