Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Air transport of the IABC patient requires a high level of skill and competence. The nurse caring for the IABP patient must be experienced in balloon pumping in a variety of settings (catheterization laboratory, operating room) and during unstable hemodynamic conditions, such as occur with arrhythmias, pacemakers, severe cardiogenic shock, and cardiac arrest. The nurse must be trained in all aspects of console operation and troubleshooting. Evanston Hospital, Evanston, Illinois, examined its experiences in ground transportation of 50 IABP patients over a 5-year period. The hospital has put forth several important principles that we have incorporated into our recommendations for air transport of the IABC patient: 1. Transport personnel should be completely familiar with the function of the IABP console; capable of handling bleeding at the balloon site, should it occur; capable of delivering intravenous medications, CPR, and ACLS; and proficient in operation of the ventilator, hemodynamic monitoring, and aerohemodynamics. 2. All patients must be stabilized before transfer. Appropriate management of hemodynamic instability and/or respiratory distress should be undertaken prior to beginning transport. 3. Medical personnel delivering care must transfer patients into and out of transport vehicles with minimal interruption of IABP. 4. Health-care professionals present during transport should be thoroughly familiar with the patient's medical status and anticipated complications. This article was not intended to teach basic principles of intra-aortic balloon pumping; rather its purpose was to discuss those characteristics of balloon pumping that are unique to flight transport and how they impact on balloon pumping. Console operation should follow manufacturer's recommendations. Table 3 summarizes features of the Aries, Datascope, Kontron, and Mansfield transport balloon pumps. Manufacturers and aircraft suppliers should be consulted for specific balloon-pump operating instructions, prior to assuming responsibility for care of the air-transport IABC patient. Well-established care plans and protocols for IABP have been published previously. Documentation of balloon-pump function during air transport is important, and can be an addenum to a standard ICU flowsheet (Fig. 4). The patient who presents at a community hospital with accelerating angina, complications following cardiac catheterization or myocardial infarction, emergency cardiac structural defects, or as a potential cardiac transplantation candidate may require institution of IABC as a life-saving intervention. Once the patient is stabilized, transport to a tertiary-care hospital that can provide advanced cardiac therapies is a logical trajectory.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Air transport of the patient requiring intra-aortic balloon pumping. 281 85

More than 30 million Americans are disabled. Wide experience has shown that these conditions do not prevent these individuals from becoming proficient in the knowledge and skills of CPR. Instructional materials and methods can be modified to help this special population learn CPR despite handicaps. The American Heart Association has supported these special efforts since 1978, but no comprehensive resource exists for CPR instructors interested in helping the "physically challenged" individual learn CPR. This article addresses general and specific suggestions for teaching selected handicapped populations. They are: hearing impaired, visually impaired, other physical impairment such as obesity, chronic obstructive pulmonary disease, arthritis, angina, and other medical conditions that may limit one's ability to learn the psychomotor skill of CPR.
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PMID:Teaching and credentialing the physically challenged: state of the art. A review of change in the clinical and scientific data since 1980. 353 65

This is a report of a postal questionnaire survey of 1250 general dental practitioners regarding occurrence of medical emergencies and their choice of emergency drugs and equipment. The response rate was 65 per cent and the results showed that about one in seven practitioners had had to resuscitate a patient. The most common medical emergencies were adverse reactions to local anaesthetics, grand mal seizures, angina pectoris and hypoglycaemia (insulin shock). Nearly all respondents (96 per cent) believed that dentists need to be competent in cardiopulmonary resuscitation, just over a half (55 per cent) felt they were competent in CPR on graduation and a similar figure (57 per cent) felt they could perform effective single person CPR for five minutes. Almost two-thirds (64 per cent) had undertaken CPR courses since graduation. Additionally, the most commonly kept emergency drugs were oxygen (63 per cent) and adrenaline (22 per cent), while the most commonly kept emergency equipment was a manual resuscitator (recoil bag-valve-mask type) which was kept by 27 per cent of the practitioners.
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PMID:Medical emergencies in dental practice and choice of emergency drugs and equipment: a survey of Australian dentists. 915 37

Although glyceryl trinitrate (GTN) has been used in the treatment of angina for many years, details of its conversion to the proximal activator (presumed to be NO or an NO congener) of soluble guanylyl cyclase (sGC) are still unclear. We reported previously that purified microsomal glutathione transferase 1 (MGST1) mediates the denitration of GTN. In the current study, we investigated in intact cells whether this enzyme also converts GTN to species that activate sGC (mechanism-based biotransformation). We utilized LLC-PK1 cells, a cell line with an intact NO/sGC/cGMP system, and generated a stable cell line that overexpressed MGST1. MGST1 in the stably transfected cells was localized to the endoplasmic reticulum, and microsomes from these cells exhibited markedly increased GST activity. Although incubation of these cells with GTN resulted in a 3-4-fold increase in GTN biotransformation, attributed primarily to an increase in formation of the 1,3-glyceryl dinitrate metabolite, GTN-induced cGMP accumulation in cells overexpressing MGST1 was not different than that observed in wild type cells or in cells stably transfected with empty vector. To determine whether overexpression of NADPH cytochrome P450 reductase might act in concert with MGST1 to generate activators of sGC, we assessed GTN-induced cGMP accumulation in MGST1-overexpressing cells that had been transiently transfected with CPR. In this case, GTN-induced cGMP accumulation was also not different than that observed in wild type cells. We conclude that although MGST1 mediates the biotransformation of GTN in intact cells, this biotransformation does not contribute to the formation of activators of sGC.
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PMID:Role of microsomal glutathione transferase 1 in the mechanism-based biotransformation of glyceryl trinitrate in LLC-PK1 cells. 1942 24