Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Conventional plasma isoenzyme and enzyme values usually are normal during the first few hours of acute myocardial infarction. Thus definitive diagnosis may be delayed. We have shown recently that infarction in dogs can be detected within 1 hr after coronary occlusion by analysis of relative activities of MM creatine kinase (CK) isoforms in plasma. Isoforms of MM CK evolve through posttranslational modifications in plasma of the form released from tissue (MMA) to MMB and MMC. In this study we quantified changes in isoform profiles in the first available plasma samples from patients with evolving myocardial infarction, from patients with angina, and from normal subjects. In the 26 control subjects, the ratio of MMA to MMC was 1.09 +/- 0.4 (SE) (range 0.31 to 3.1; upper limit of normal [defined as the mean plus 2 SD] 2.5). In the seven control patients with coronary artery disease, the ratio of MMA to MMC was 1.3 +/- 0.3 with a range of 0.5 to 2.5. In contrast, among the 28 patients with acute myocardial infarction, the ratio of MMA to MMC in the first available plasma sample averaged 14.6 +/- 4.5 (p less than .01 compared with both control groups). First available samples were obtained 3.9 +/- 0.4 hr after the onset of pain. In 24 of 28 patients (86%) the ratio of MMA to MMC was greater than 2.5.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Diagnostic changes in plasma creatine kinase isoforms early after the onset of acute myocardial infarction. 370 69

Prevention of ischemic bowel complications following abdominal aortic reconstruction requires identification of the patient at high risk for developing the complication; on precise, gentle, meticulous operative technique; on knowledge of bowel blood supply; on determining when the IMA must be reconstructed or when it can be safely ligated; and on methods of preserving or preventing damage to bowel blood supply. Patients at greatest risk for developing bowel ischemia following aortic reconstruction include those with a history of visceral angina, those with a patent IMA (40% to 52%), those being treated for ruptured aneurysm, those whose postreconstructive IMA stump mean blood pressures are less than 40 torr, those in whom Doppler flow signals cease following division or occlusion of the IMA, and those who have SMA occlusive disease and arteriographic documentation of IMA to SMA flow in the MMA (Table II). Patients at least risk include those in whom the IMA is already occluded (48% to 60%), those whose postreconstructive IMA stump pressures are more than 40 torr, those in whom Doppler flow signals persist after IMA occlusion, those who have flow in the MMA from the SMA to the IMA (provided this vessel is not injured), and those undergoing aortic reconstruction for aortoiliac occlusive disease.
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PMID:Prevention of intestinal ischemia following abdominal aortic reconstruction. 684 80