Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients with severe classic angina pectoris and no evidence of myocardial infarction are described. All had ECG changes compatible with myocardial ischemia. Coronary arteriography showed normal coronary arteries (except for minor narrowing in one patient) and marked hypertrophy of the left ventricle without left ventricular outflow tract obstruction. The diagnosis of hypertrophic nonobstructive cardiomyopathy was confirmed by the presence of small left ventricular diastolic and systolic volumes with a supernormal ejection fraction indicative of a hypercontractile state of the left ventricle. Treatment with beta-blocking agents reduced myocardial work, improved diastolic compliance and decreased patients' anginal symptoms. Hypertrophic nonobstructive cardiomyopathy is an important cause of typical angina pectoris in patients who have normal coronary arteries on coronary angiography.
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PMID:Hypertrophic nonobstructive cardiomyopathy as a cause of angina pectoris. 644 28

There has recently been an increasing interest in beneficial effects of cardiac pacing in patients with myocardial diseases, especially in Obstructive Hypertrophic and Dilated Cardiomyopathy. The experience with dual-chamber pacing for obstructive hypertrophic cardiomyopathy is now important. DDD pacing for sinus rhythm patients and VVI pacing in patients with atrial fibrillation have shown considerable symptomatic improvement, with a significant decrease of angina, dyspnea, presyncope and frank syncope. It has been suggested that DDD pacing may prevent sudden death and improve survival rates in these patients, but this has not yet been established. The experience with DDD pacing in dilated cardiomyopathy is more limited, but in specially chosen patients, DDD pacing with short AV delay has shown symptomatic improvement and a decrease in the need for further hospitalization due to worsening of heart failure. There is no current evidence of higher survival rates with this treatment, but DDD pacing may be used in patients with end-stage dilated and isquemic cardiomyopathy who are waiting for a heart transplantation.
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PMID:[Impact of electric cardiac stimulation on ventricular function and the natural history of patients with myocardiopathy]. 875 4