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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been shown by many authors that afferent stimulation of various somatic nerves results in the different types of responses with regard to blood pressure and heart rate. It was revealed by Hunt that afferent "weak" stimulation of the somatic nerves caused depressor responses, and "strong" stimulation, pressor responses. Ranson and Gordon thought that the depressor response to the afferent stimulation of the somatic nerves would involve the thick myelinated nerve fibers, and the pressor response, the fine non-myelinated nerve fibers. On the other hand, it has been postulated that the socalled chest pain and/or nonspecific complaints observed in patients with myocardial infarction, angina pectoris and neurocirculatory asthenia (NCA) are related to some alterations at the cervical and thoracic vertebral levels of the spinal cord or nerve roots. Maekawa, Hayase and Konishi attached importance to the presence of subclinical arachnoiditis adhesiva cerebrospinalis at the cervical and thoracic vertebral levels in patients of NCA. These facts suggests that the contribution of the spinal cord and the nerve roots to the circularoty system is different between the cervico-thoracic levels and the lumbar levels. Based on these facts, the author stimulated the somatic nerves of both the forelimbs and the hindlimbs afferently in alpha-chloralose anesthetized dogs, with a train of square electric pulses for 20 seconds, and studied the response of the circulatory system to such stimuli.
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PMID:[Experimental study on the changes of blood pressure induced by afferent stimulation on the somatic nerves (author's transl)]. 127 79

We have performed single-neuron recording and microstimulation in the region of the thalamic principal sensory nucleus (ventrocaudal nucleus, Vc) prior to implantation of a deep brain-stimulating electrode in a patient with pain secondary to arachnoiditis and with a past history of unstable angina. Cells located in the 16 mm lateral plane had cutaneous receptive fields on the chest wall. At and posterior to the location of these cells stimulation coincided precisely with the sensation of angina (stimulation-associated angina). The description of stimulation-associated angina was measured using a questionnaire and was identical to the patient's usual angina except that it began and terminated suddenly. Stimulation-associated angina was coincident with a tingling sensation in the leg. Clinical, hemodynamic, electrophysiologic and biochemical measures of cardiac function showed no evidence of myocardial strain or injury related to stimulation-associated angina. Since cells in the region of the principle sensory nucleus of thalamus respond to cardiac injury in animals, the present results suggest that this region mediates the sensation of angina.
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PMID:The sensation of angina can be evoked by stimulation of the human thalamus. 785 92