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Query: UMLS:C0002962 (angina)
 21,142 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Here we describe a case of angina pectoris in a patient for whom an extensive cardiovascular workup was done, with negative results. Eventually, the cause of his symptoms was found to be pernicious anemia. Although angina is an uncommon manifestation of pernicious anemia, a review of the literature suggests that the correlation between anemia and angina has been well described. Our case highlights an important differential diagnosis to consider for patients with exercise-induced chest pain and serves to emphasize the attention that should be focused on simple screening laboratory studies. The emphasis in this case is the sequence in which the studies are done. A simple complete blood count with proper interpretation and intervention at the outset of evaluation could possibly have prevented a number of unnecessary, invasive, and costly studies.
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PMID:Pernicious anemia manifesting as angina pectoris. 820 83

The term "leukopenic myelosis" is used to describe a type of "myeloblastic leukaemia" in which the leukocyte content of the peripheral blood is subnormal for the whole or the greater part of the course of the disease. Separation from the frankly leukaemic cases is made only on the grounds of clinico-haematological convenience.Twenty-two cases have been seen in the past four years. The age-incidence varied from 3-73 years; 10 were in males and 12 in females. Acute, subacute, and chronic types may be recognized. In all the main characteristic is a progressive anaemia; in acute cases haemorrhagic phenomena and necrotic angina are common.The blood-count is characterized by orthochromic or hyperchromic anaemia, sometimes with reticulocytosis and erythroblastosis. Leukopenia may persist throughout the course, or a terminal leukaemia may occur-especially in the chronic cases. The features of the differential count are the presence of myeloblasts-although the percentage may be below 5%-and the hiatus leukaemicus. Thrombocytopenia usually means a rapid course.This clinico-haematological picture may be mimicked more or less closely by pernicious anaemia, aplastic anaemia, agranulocytosis, and the leuko-erythroblastic anaemias. The sternal puncture findings are, however, diagnostic, and show a great preponderance of primitive myeloid cells, most frequently with a predomincnce of myeloblasts. In two cases evidence was found that the erythropoietic tissues shared in the hyperplasia.
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PMID:Leukopenic Myelosis: (Section of Medicine). 1999 28