Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002895 (sickle cell disease)
 11,747 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
SCD 11.4
SEC31B 11.4
OR51B2 11.4
Gamma globin 10.4
POLR3H 10.4
BRI3BP 10.4
RAB3IL1 10.4
OR51B6 10.4
OR51B5 10.4
FERM and PDZ domain-containing protein 4 10.4
C10orf71 10.4
ACBD7 10.4
HBS1L 10.1
Lutheran blood group glycoprotein 10.0
HBG2 9.9
BCL11A 9.9
TOR2A 9.8
PTPLB 9.8
stearoyl-CoA desaturase 5 9.8
NPEPL1 9.8
AGPAT6 9.8
BCAM 9.8
HBG1 9.5
HAO2 9.4
LICR2 9.4
PECR 9.4
ACSM5 9.4
TMEM24 9.4
PNRC1 9.4
HELO1 9.4
basal cell adhesion molecule 9.4
INSIG1 9.4
ACACA 9.3
Lutheran glycoprotein 9.3
LW blood group 9.2
ICAM-4 9.2
BRCA2 and CDKN1A interacting protein 9.1
CPXM2 9.1
GOLGB1 9.1
myosin, heavy chain 9, non-muscle 9.1
exocyst complex component 6B 9.1
ZNF613 9.1
PLEKHA2 9.1
mitochondrial intermediate peptidase 9.1
ACSS2 9.0
laminin alpha 5 8.9
gamma-globin chain 8.9
GPAM 8.8
PLA2G12A 8.8
FADS6 8.8
KIAA1755 8.8
TESK2 8.8
MIER1 8.8
QTRT1 8.8
glutathione S-transferase mu 2 8.8
FASN 8.8
AGPAT1 8.7
SCD2 8.7
EIF2AK1 8.7
ELOVL7 8.7
ACAA1 8.7
HBB 8.7
LPIN1 8.6
ACSS1 8.6
delta-globin chain 8.6
GRLF1 8.6
phosphodiesterase 9A 8.6
FATP5 8.6
CCNT2 8.6
PLEKHB1 8.6
SAR1A 8.6
gamma-globin 8.6
ITM2C 8.4
PNPLA7 8.4
PAQR6 8.4
CCDC103 8.4
GIMAP6 8.4
BTN 8.4
MYOM1 8.4
truncated beta-globin 8.4
more...
Disease
Tonsillar actinomycosis 11.4
Hepatic vascular disorders 11.4
Sickle cell nephropathy 11.4
Torulopsis infection 11.4
Other hemoglobinopathies 11.4
sickle cell disease 11.4
SCD 11.3
acute chest syndrome 11.2
LFSS 11.0
sickle cell crisis 10.8
Cardiac siderosis 10.8
sickle thalassemia 10.8
Sickle cell retinopathy 10.6
Hb SC disease 10.4
HbS-HbD disease 10.4
myelodysplastic anemia 10.4
Hb-C disease 10.4
Splenic sequestration 10.4
Hemoglobin SE disease 10.4
Functional asplenia 10.0
Nocardia sepsis 9.8
Infective spondylitis 9.8
Salmonella osteomyelitis 9.8
hemoglobinopathies 9.7
Sickle cell trait 9.5
Chronic pain syndrome 9.4
Hemolytic transfusion reaction 9.4
Gamna 9.2
Peripheral retinal neovascularization 9.1
Ataxic dysarthria 9.1
Tuftsin deficiency 9.1
Cardiac dilatation 9.1
Iris atrophy 9.1
Chronic leg ulcer 9.1
Other metabolic disorders 9.1
hereditary persistence of fetal hemoglobin 8.9
blood disorder 8.9
Acute cor pulmonale 8.8
Macular ischemia 8.8
priapism 8.8
HBB 8.7
HBB 8.7
HBB 8.7
Pneumococcal sepsis 8.6
thalassemia 8.6
beta thalassemia 8.4
HPFH 8.4
Erythroid hyperplasia 8.4
Pneumococcal bacteremia 8.4
alpha thalassemia 8.3
hyposplenism 8.3
Alloimmunization 8.3
ATMDS 8.2
Bacterial osteomyelitis 8.2
Haemophilus influenzae septicemia 8.2
Pulmonary artery thrombosis 8.2
Negative thoughts 8.2
Penile gangrene 8.2
Cocaine intoxication 8.1
Spinal osteomyelitis 8.1
Fusobacterium infection 8.1
Bellini duct carcinoma 8.0
Relative polycythaemia 7.9
Bilateral hearing loss 7.9
Chronic anemia 7.9
thalassemia trait 7.9
Secondary osteoarthritis 7.8
dactylitis 7.8
nonmalignant hematologic disorders 7.7
dual personality 7.7
COND 7.7
hereditary spherocytosis 7.7
Acute anemia 7.6
Blackwater fever 7.6
Cardiac embolism 7.6
Overwhelming post-splenectomy infection 7.6
thalassemia major 7.5
aregenerative anemia 7.5
Cross infection 7.5
Renal abscess 7.5
more...
Symptom
Girdle pain 11.4
Painless hematuria 9.4
Rebound tenderness 8.6
Frequent headaches 8.6
liver pain 8.4
Reticulocytosis 8.1
Penile pain 8.1
abnormal breath sounds 7.8
Other pain 7.7
painful erections 7.2
Thoracic pain 7.1
Injection site pain 7.1
Procedural pain 6.8
Pneumobilia 6.8
abnormal taste 6.5
Severe pain 6.4
acute pain 6.3
left upper quadrant pain 6.0
musculoskeletal disability 5.9
Livedoid 5.8
thoracic back pain 5.6
generalized pain 5.4
PAIN 5.3
Signs and Symptoms 5.3
dark urine 5.3
bone pain 5.2
feeling tired 5.1
splenomegaly 4.9
growing pains 4.8
bedwetting 4.8
cardiovascular impairment 4.6
pallor 4.6
right upper quadrant pain 4.6
Exercise intolerance 4.6
facial droop 4.4
periorbital edema 4.4
hepatomegaly 4.3
hip pain 4.3
decreased appetite 4.2
leg cramps 4.2
nocturnal polyuria 4.2
enuresis 4.2
Physical findings 4.0
testicular pain 4.0
Decreased activity 3.9
jaw pain 3.9
arm weakness 3.9
Neurologic symptoms 3.9
prostration 3.9
pleuritic chest pain 3.8
breakthrough pain 3.7
Cushingoid 3.7
acute abdominal pain 3.6
limb pain 3.6
Cushingoid 3.6
metamorphopsia 3.5
pain 3.5
body pain 3.3
right lower quadrant pain 3.1
loin pain 3.1
analgesia 3.0
Sedation 3.0
meningism 3.0
chest pain 3.0
flank pain 2.9
catatonia 2.9
Tenderness 2.9
eye pain 2.8
chest tightness 2.8
Scratch 2.8
Depressive symptoms 2.8
wheezing 2.8
hemiplegia 2.8
shortness of breath 2.8
fever of unknown origin 2.7
arthralgia 2.7
abdominal pain 2.7
hepatosplenomegaly 2.6
clubbing 2.6
Halo 2.6
more...
Drug
Senicapoc 9.7
Celsis 8.6
Deferasirox 8.3
Cassia seed 8.2
Colestimide 7.4
Innohep 7.3
Elmiron 7.3
Glucose-6-Phosphate 7.1
Deferoxamine mesylate 6.9
Regadenoson 6.8
Sodium Nitroprusside 6.8
Hemopure 6.8
Sodium phenylbutyrate 6.6
Atarax 6.6
K201 6.4
Cocoa butter 6.3
Hydroxyethylstarch 6.3
Andriol 6.2
Trental 6.1
Trenbolone acetate 6.0
Aggrastat 6.0
Demerol 6.0
Domin 6.0
Phosphatidylserine 5.8
Benserazide 5.6
Poloxamer 188 5.6
Desferal 5.6
Tropicamide 5.5
Desferal 5.4
Demerol 5.4
Eptifibatide 5.3
Implanon 4.9
Sodium thiosulfate 4.8
Sodium acetate 4.7
Basiliximab 4.6
Basiliximab 4.6
Depo-Provera 4.6
Liposyn 4.6
Ara-A 4.6
Piracetam 4.5
Eculizumab 4.5
Dakar 4.5
Heme 4.5
Ora 4.4
Cellulose acetate 4.3
Epoetin 4.3
Sulphasalazine 4.2
Zileuton 4.1
VCR 4.1
Darbepoetin alfa 4.0
Iodixanol 4.0
Tenofovir disoproxil fumarate 4.0
Filgrastim 3.9
THA 3.9
TRM 3.9
Kollidon 3.9
Abatacept 3.8
Nitric Oxide 3.8
Filgrastim 3.8
Ranibizumab 3.7
Poloxamer 3.7
Bosentan 3.7
Bosentan 3.7
Alteplase 3.6
Pirfenidone 3.5
Fansidar 3.5
Thioridazine 3.5
Fansidar 3.4
Alteplase 3.4
Sodium hypochlorite 3.4
AGG 3.4
Kenyan 3.3
Orphan 3.3
KCL 3.3
Alteplase 3.3
ID2 3.3
Ketorolac 3.2
Abciximab 3.1
Rimonabant 3.1
Rutin 3.0
more...
Enzyme
protein methylase II 6.5
phosphoglyceromutase 6.1
galactosylhydroxylysyl glucosyltransferase 6.0
LPL 5.9
GDP-mannose 4,6-dehydratase 5.8
scytalone dehydratase 5.7
cathepsin V 5.4
Delta6-desaturase 5.4
biotinidase 5.4
SNO 5.1
CSAD 5.1
CDP-diacylglycerol synthase 4.8
uracil phosphoribosyltransferase 4.7
LMT 4.6
PRT 4.6
EC 2.7.7.9 4.5
glyoxalase II 4.5
arginase 4.4
C3b inactivator 4.4
iodothyronine 5'-deiodinase 4.3
CPT 4.2
factor D 4.2
FADS 4.2
methylenetetrahydrofolate reductase 4.2
methylenetetrahydrofolate reductase 4.2
fatty-acid synthase 4.1
CPT 4.1
ribonucleotide reductase 4.1
glucose-6-phosphate dehydrogenase 4.0
ribonucleotide reductase 4.0
fatty acid desaturase 4.0
BMT 3.9
carboxypeptidase G2 3.9
sphingosine kinase 3.9
heme oxygenase 3.8
CPT 3.8
acetyl-CoA carboxylase 3.8
TDH 3.6
ancrod 3.6
mu-calpain 3.6
AMP-activated kinase 3.5
Rex 3.5
STK11 3.5
estrogen sulfotransferase 3.5
acyl-CoA oxidase 3.5
cytosine deaminase 3.4
lactate dehydrogenase 3.4
N-acetylglucosaminyltransferase 3.4
TGT 3.4
lysophosphatidylcholine acyltransferase 3.4
AMPK 3.3
acyl-CoA synthetase 3.3
biliverdin reductase 3.3
dihydroorotase 3.2
hormone-sensitive lipase 3.1
PDK1 3.1
granule-bound starch synthase 3.1
CYP7A1 3.0
GTP cyclohydrolase I 3.0
orotidine-5'-phosphate decarboxylase 3.0
ALA synthase 3.0
cholesterol oxidase 3.0
type III procollagen 3.0
FPS 3.0
acyl-CoA dehydrogenase 2.9
glycolate oxidase 2.9
ornithine aminotransferase 2.9
3-hydroxy-3-methylglutaryl-CoA reductase 2.9
CEP 2.9
peroxiredoxin 2.8
AST 2.8
dihydropteridine reductase 2.7
UDP-glucuronosyltransferase 2.7
DNA methyltransferase 2.7
thrombin 2.7
TSP-1 2.7
acyl-CoA synthetase 2.7
PTR 2.6
LasR 2.6
aspartate aminotransferase 2.6
more...
Compound
C20H24O3 10.4
N-Phenylacetyl-L-phenylalanine 10.4
C20H24O3 10.4
C20H24O3 10.4
C20H24O3 10.4
C20H24O3 10.4
C20H24O3 10.4
C20H24O3 10.4
C20H24O3 9.8
Hydroxyurea 9.5
Centrolobine 9.4
Benzenemethanethiol 9.4
Cetiedil 8.7
HBB 8.6
C20H24O3 8.6
Tropic acid 8.4
Bantu 8.2
Nereistoxin 8.1
Trichothecin 7.9
DHA ethyl ester 7.8
Jatrophone 7.8
PTMS 7.8
hexyl hexanoate 7.5
Benin 7.5
Mometasone 7.4
Hemoglobin 7.1
Stearoyl-CoA 7.0
Angelicin 6.9
PGD3 6.9
Cholesteryl oleate 6.8
Cholesteryl oleate 6.8
SAD 6.5
CHNO 6.5
phytanoyl-CoA 6.4
Clotrimazole 6.3
Dimethylglycine 6.3
Azimilide 6.0
propionyl-carnitine 5.9
MCH 5.9
2,3-diphosphoglycerate 5.9
PPBP 5.9
tropic acid 5.8
Phosphatidylserine 5.8
Phthalimide 5.8
Tetrahydrouridine 5.7
ethyl propiolate 5.7
Desmosine 5.7
2-butoxyethanol 5.7
Phenylethanolamine 5.6
Anacardic acid 5.6
Isoquercitrin 5.6
DPG 5.5
Rutaecarpine 5.5
Cyanate 5.4
Cholesterol sulfate 5.4
Desferal 5.4
F6P 5.4
Rutaecarpine 5.4
F6P 5.4
Hemin 5.4
Hemin 5.4
Hemin 5.4
Hemin 5.4
1-naphthyl acetate 5.4
cyclopropanecarboxylic acid 5.4
5-Aza-2'-deoxycytidine 5.4
cyclopropanecarboxylic acid 5.3
Hemin 5.3
Valacyclovir 5.2
5-Azacytidine 5.2
butoxyacetic acid 5.1
Palmitoleic acid 5.1
1,4-pentadiene 5.1
LCR 5.1
Norgestrel 5.0
cholest-5-ene 5.0
Hydromorphone 5.0
1,2-dithiolane 4.9
DPG 4.9
Ticlopidine 4.9
more...