Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0002895 (sickle cell disease)
11,747 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein hemoglobin 2400 SCD 1046 Sep 670 erythroid 401 Mol 382 beta-globin 270 ferritin 171 HLA 139 MRI 124 vascular endothelium 122 gamma-globin 116 methemoglobin 116 insulin 114 stearoyl-CoA desaturase 112 lactate dehydrogenase 111 HBB 109 cytokine 108 BCL11A 105 erythropoietin 99 She 82 FASN 80 thrombin 79 CD34 69 FAS 67 albumin 65 vascular cell adhesion molecule-1 62 IL-6 58 P-selectin 58 TNF 57 beta globin 56 fibrinogen 55 B19 53 tumor necrosis factor 52 adhesion molecule 51 transferrin 50 MYB 49 C-reactive protein 48 heme oxygenase-1 48 ATP 47 prothrombin 47 alkaline phosphatase 45 collagen 43 nitric oxide synthase 43 tissue factor 43 endothelin-1 42 glucose-6-phosphate dehydrogenase 41 CD36 41 NMR 40 SCD1 40 haptoglobin 40 SREBP-1c 39 IL-8 38 LDH 38 ACACA 38 endonuclease 37 HDL 37 von Willebrand factor 36 human leukocyte antigen 34 E-selectin 33 HBS1L 33 superoxide dismutase 33 catalase 33 chronic renal failure 32 vascular endothelial growth factor 32 A-I 32 GSH 32 SREBP-1 32 ACC 32 protein C 31 LPL 31 C18 31 aspartate aminotransferase 31 ICD 30 HBG2 30 melanin-concentrating hormone 30 hemochromatosis 28 hemopexin 28 FABP4 28 glycoprotein 28 ACS 27 more...

Disease sickle cell disease 11747 thalassemia 1474 SCD 1046 hemoglobinopathies 809 anemia 804 stroke 778 acute chest syndrome 500 cancer 407 hemolytic anemia 306 malaria 280 diabetes 272 pulmonary hypertension 265 iron overload 238 priapism 216 hypertension 215 ischemia 214 renal disease 191 osteomyelitis 182 sepsis 179 leg ulcers 159 sickle cell crisis 157 thalassemia major 152 chronic pain 148 West 147 cystic fibrosis 136 genetic disorder 134 sepsis 132 gallstones 131 HIV 129 dehydration 129 asthma 129 retinopathy 113 beta thalassemia 111 HBB 109 HBB 109 HBB 109 pneumonia 108 depression 107 infectious diseases 104 graft-versus-host disease 103 tumor 102 blood disorder 101 obesity 98 leukemia 98 meningitis 89 hereditary spherocytosis 84 heart failure 84 renal failure 78 atherosclerosis 78 cold 78 iron deficiency 78 proteinuria 77 parvovirus 70 malnutrition 69 FAS 67 myocardial infarction 65 immunodeficiency 65 heart disease 65 moyamoya 63 G6PD deficiency 62 systemic lupus erythematosus 62 myelodysplastic syndrome 58 AIDS 58 cerebral infarction 58 haemophilia 55 thrombocytopenia 54 bacteremia 53 chronic renal failure 53 lung disease 53 cirrhosis 52 hereditary persistence of fetal hemoglobin 50 vascular disease 50 aplastic anemia 49 Haemophilus 49 cardiovascular disease 48 liver disease 46 chronic disease 46 cardiomyopathy 46 abortion 45 Infection 44 more...

Symptom pain 1063 acute pain 113 splenomegaly 110 analgesia 85 headache 74 abdominal pain 73 anesthesia 71 seizures 70 chest pain 50 hepatomegaly 42 bone pain 41 diarrhea 40 fatigue 39 respiratory distress 35 dyspnea 27 weakness 27 hypothermia 27 collapse 24 back pain 24 cough 24 erythema 23 pallor 23 stigma 22 vomiting 21 arthralgia 17 nausea 16 shortness of breath 13 hip pain 13 wheezing 12 discomfort 11 overweight 11 lethargy 11 discomfort 11 enuresis 11 syncope 11 hemiplegia 10 thinning 10 hepatosplenomegaly 10 anorexia 10 acute abdominal pain 9 exhaustion 9 myalgia 9 angina 9 decreased appetite 8 dizziness 8 low back pain 7 paresthesia 7 regurgitation 6 flank pain 6 hyperoxia 6 snoring 6 agitation 6 right upper quadrant pain 6 vertigo 6 nausea and vomiting 5 knee pain 5 Ill 5 Severe pain 5 tremor 5 ataxia 5 fever of unknown origin 5 hypercapnia 5 spasm 5 chills 5 Reticulocytosis 5 cancer pain 5 Depressive symptoms 5 tachypnea 4 Sedation 4 insomnia 4 constipation 4 distraction 4 acute abdomen 4 dark urine 4 paraparesis 4 exertional dyspnea 4 starvation 4 facial pain 4 ENT 4 polyuria 3 more...

Drug Cardiovasc 46 Asthma 30 Heme 26 vitamin E 24 lysine 23 ascorbate 23 Dermatol 23 Deferasirox 23 CSF 19 Dakar 18 Phosphatidylserine 14 CAM 14 Nitric Oxide 13 Kenyan 13 DNase I 13 ROS 12 IFN-gamma 10 VCR 10 NADH 10 G-CSF 9 MAP 9 IL-2 9 ROC 8 Vitamin E 8 ampicillin 7 Dial 6 Depo-Provera 6 CTX 6 Monit 6 Gel 6 Senicapoc 5 Nephron 5 G418 5 THA 5 ENT 5 lactose 5 EPA 5 Desferal 5 EPI 5 Nephron 5 Fluorescein 5 Fluorescein 4 Poloxamer 188 4 nitroglycerin 4 Albumin 4 Glutathione 4 Desferal 4 Trental 4 PTH 4 MDS 4 Leaf 4 Ringer's solution 4 AGG 3 pyridoxal phosphate 3 Mutagen 3 Simvastatin 3 Norplant 3 Piracetam 3 Eculizumab 3 CTX 3 Hydroxyethylstarch 3 Prednisolone 3 CTX 3 Indomethacin 3 niacin 3 Spectrum 3 THF 3 Vitamin A 3 TAT 3 Histamine 3 Forskolin 2 Orphan 2 Cellulose acetate 2 ETA 2 Filgrastim 2 Luteinizing 2 Regadenoson 2 BH4 2 TRM 2 Epoetin 2 more...

Enzyme lactate dehydrogenase 116 thrombin 79 aspartate aminotransferase 48 glucose-6-phosphate dehydrogenase 47 alkaline phosphatase 45 superoxide dismutase 44 catalase 42 alanine aminotransferase 42 protein kinase 41 endonuclease 37 peroxidase 37 mitogen-activated protein kinase 36 APC 36 ERK 35 LPL 31 arginase 29 AMP-activated protein kinase 28 ACS 27 luciferase 25 AMPK 24 NO synthase 24 CPT 24 AMPK 23 CPT 22 ATPase 22 heme oxygenase 22 CPT 22 NADPH oxidase 22 NADPH oxidase 21 glutathione peroxidase 20 focal adhesion kinase 20 phosphodiesterase 19 protein kinase C 19 renin 19 ribonucleotide reductase 18 ribonucleotide reductase 18 ACE 18 AST 16 acetyl-CoA carboxylase 15 BMT 15 methylenetetrahydrofolate reductase 14 methylenetetrahydrofolate reductase 14 guanylate cyclase 13 xanthine oxidase 13 thromboplastin 13 trypsin 12 tissue plasminogen activator 12 DNA methyltransferase 12 phospholipase A2 11 NOS 11 glutathione reductase 11 glutathione S-transferase 10 ceruloplasmin 10 RNA polymerase 9 reverse transcriptase 9 adenosine deaminase 9 adenosine deaminase 9 UDP-glucuronosyltransferase 8 lipoprotein lipase 7 proteasome 7 hormone-sensitive lipase 7 peroxiredoxin 7 PDK1 7 neuraminidase 6 plasmin 6 biotinidase 6 pyruvate kinase 6 glyceraldehyde-3-phosphate dehydrogenase 6 creatine kinase 5 lipase 5 caspase-3 5 PKG 5 MEK 5 RNase 5 aldehyde dehydrogenase 5 RNase 5 MDP 5 glyceraldehyde-3-phosphate dehydrogenase 5 SNO 5 phosphoglyceromutase 5 more...

Compound Clin 1118 Dec 785 oxygen 651 DNA 467 iron 446 Hemoglobin 366 Hydroxyurea 313 nitric oxide 308 calcium 147 water 146 sodium 142 glucose 110 HBB 109 creatinine 109 zinc 102 Benin 101 arginine 99 phosphate 93 CO2 71 potassium 69 Bantu 64 urea 62 acetate 61 Cardiol 60 TNF 57 valine 55 His 51 nitrogen 47 ATP 47 glutamine 46 glutamic acid 45 hydrogen 44 lysine 40 GSH 36 GSH 36 salt 34 SAD 32 MCH 30 nitrate 29 2,3-diphosphoglycerate 29 vitamin D 28 Heme 28 ACS 27 tyrosine 27 ACS 27 cysteine 27 cAMP 26 leucine 25 cGMP 24 CoA 24 ethanol 24 GTP 24 homocysteine 24 copper 22 CPT 22 sulfate 22 ADP 22 CPT 22 methionine 21 Phe 21 alanine 21 DPG 20 DPG 20 serine 19 ADP 18 ADP 18 prostacyclin 17 glutamate 17 butyric acid 17 EDTA 16 EDTA 16 PEG 16 Mg2+ 16 glycerol 16 threonine 16 aldosterone 15 aldehyde 15 MDA 15 NADPH 14 retinol 14 more...

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