Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0002895 (sickle cell disease)
11,747 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein hemoglobin 2400 SCD 1046 Sep 670 erythroid 401 Mol 382 beta-globin 270 ferritin 171 HLA 139 MRI 124 vascular endothelium 122 gamma-globin 116 methemoglobin 116 insulin 114 stearoyl-CoA desaturase 112 lactate dehydrogenase 111 HBB 109 cytokine 108 BCL11A 105 erythropoietin 99 She 82 FASN 80 thrombin 79 CD34 69 FAS 67 albumin 65 vascular cell adhesion molecule-1 62 IL-6 58 P-selectin 58 TNF 57 beta globin 56 fibrinogen 55 B19 53 tumor necrosis factor 52 adhesion molecule 51 transferrin 50 MYB 49 heme oxygenase-1 48 C-reactive protein 48 ATP 47 prothrombin 47 more...

Disease sickle cell disease 11747 thalassemia 1474 SCD 1046 hemoglobinopathies 809 anemia 804 stroke 778 acute chest syndrome 500 cancer 407 hemolytic anemia 306 malaria 280 diabetes 272 pulmonary hypertension 265 iron overload 238 priapism 216 hypertension 215 ischemia 214 renal disease 191 osteomyelitis 182 sepsis 179 leg ulcers 159 sickle cell crisis 157 thalassemia major 152 chronic pain 148 West 147 cystic fibrosis 136 genetic disorder 134 sepsis 132 gallstones 131 asthma 129 dehydration 129 HIV 129 retinopathy 113 beta thalassemia 111 HBB 109 HBB 109 HBB 109 pneumonia 108 depression 107 infectious diseases 104 graft-versus-host disease 103 more...

Symptom pain 1063 acute pain 113 splenomegaly 110 analgesia 85 headache 74 abdominal pain 73 anesthesia 71 seizures 70 chest pain 50 hepatomegaly 42 bone pain 41 diarrhea 40 fatigue 39 respiratory distress 35 dyspnea 27 weakness 27 hypothermia 27 back pain 24 cough 24 collapse 24 erythema 23 pallor 23 stigma 22 vomiting 21 arthralgia 17 nausea 16 hip pain 13 shortness of breath 13 wheezing 12 syncope 11 discomfort 11 discomfort 11 lethargy 11 overweight 11 enuresis 11 hemiplegia 10 anorexia 10 hepatosplenomegaly 10 thinning 10 acute abdominal pain 9 more...

Drug Cardiovasc 46 Asthma 30 Heme 26 vitamin E 24 Dermatol 23 Deferasirox 23 lysine 23 ascorbate 23 CSF 19 Dakar 18 CAM 14 Phosphatidylserine 14 Nitric Oxide 13 Kenyan 13 DNase I 13 ROS 12 NADH 10 VCR 10 IFN-gamma 10 MAP 9 G-CSF 9 IL-2 9 ROC 8 Vitamin E 8 ampicillin 7 CTX 6 Gel 6 Depo-Provera 6 Dial 6 Monit 6 G418 5 Senicapoc 5 Nephron 5 EPA 5 ENT 5 lactose 5 EPI 5 Desferal 5 THA 5 Fluorescein 5 more...

Enzyme lactate dehydrogenase 116 thrombin 79 aspartate aminotransferase 48 glucose-6-phosphate dehydrogenase 47 alkaline phosphatase 45 superoxide dismutase 44 catalase 42 alanine aminotransferase 42 protein kinase 41 endonuclease 37 peroxidase 37 mitogen-activated protein kinase 36 APC 36 ERK 35 LPL 31 arginase 29 AMP-activated protein kinase 28 ACS 27 luciferase 25 AMPK 24 CPT 24 NO synthase 24 AMPK 23 NADPH oxidase 22 ATPase 22 heme oxygenase 22 CPT 22 CPT 22 NADPH oxidase 21 glutathione peroxidase 20 focal adhesion kinase 20 renin 19 protein kinase C 19 phosphodiesterase 19 ribonucleotide reductase 18 ribonucleotide reductase 18 ACE 18 AST 16 BMT 15 acetyl-CoA carboxylase 15 more...

Compound Clin 1118 Dec 785 oxygen 651 DNA 467 iron 446 Hemoglobin 366 Hydroxyurea 313 nitric oxide 308 calcium 147 water 146 sodium 142 glucose 110 HBB 109 creatinine 109 zinc 102 Benin 101 arginine 99 phosphate 93 CO2 71 potassium 69 Bantu 64 urea 62 acetate 61 Cardiol 60 TNF 57 valine 55 His 51 ATP 47 nitrogen 47 glutamine 46 glutamic acid 45 hydrogen 44 lysine 40 GSH 36 GSH 36 salt 34 SAD 32 MCH 30 2,3-diphosphoglycerate 29 nitrate 29 more...

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