Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002895 (sickle cell disease)
 11,747 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hemoglobin 2400
SCD 1046
Sep 670
erythroid 401
Mol 382
beta-globin 270
ferritin 171
HLA 139
MRI 124
vascular endothelium 122
gamma-globin 116
methemoglobin 116
insulin 114
stearoyl-CoA desaturase 112
lactate dehydrogenase 111
HBB 109
cytokine 108
BCL11A 105
erythropoietin 99
She 82
FASN 80
thrombin 79
CD34 69
FAS 67
albumin 65
vascular cell adhesion molecule-1 62
IL-6 58
P-selectin 58
TNF 57
beta globin 56
fibrinogen 55
B19 53
tumor necrosis factor 52
adhesion molecule 51
transferrin 50
MYB 49
heme oxygenase-1 48
C-reactive protein 48
ATP 47
prothrombin 47
alkaline phosphatase 45
nitric oxide synthase 43
collagen 43
tissue factor 43
endothelin-1 42
CD36 41
glucose-6-phosphate dehydrogenase 41
haptoglobin 40
SCD1 40
NMR 40
SREBP-1c 39
IL-8 38
LDH 38
ACACA 38
endonuclease 37
HDL 37
von Willebrand factor 36
human leukocyte antigen 34
catalase 33
superoxide dismutase 33
E-selectin 33
HBS1L 33
GSH 32
vascular endothelial growth factor 32
chronic renal failure 32
SREBP-1 32
A-I 32
ACC 32
protein C 31
C18 31
aspartate aminotransferase 31
LPL 31
melanin-concentrating hormone 30
ICD 30
HBG2 30
hemopexin 28
FABP4 28
hemochromatosis 28
glycoprotein 28
ACS 27
fatty acid synthase 27
FADS2 26
PPAR 26
lymphoid 26
fibronectin 26
thrombospondin 26
protein S 25
gamma globin 25
placental growth factor 25
IgA 25
IL-10 25
ABO 25
endothelial nitric oxide synthase 24
PPARG 24
interleukin-6 24
hematopoietic stem and progenitor cells 24
SREBF1 24
TLR4 23
white cell 23
interferon 23
Stearoyl-CoA desaturase 23
antithrombin 23
adiponectin 22
histone deacetylase 22
CPT 22
membrane protein 22
annexin V 22
ICAM-1 22
transferrin receptor 22
Cytokine 22
AMPK 22
peroxisome proliferator-activated receptor 21
gut 21
chemokine 21
P50 21
DGAT1 21
reserved 20
JAMA 20
alanine aminotransferase 20
KLF1 20
glutathione peroxidase 20
endoplasmic reticulum 20
leptin 20
phosphodiesterase 19
TNF-alpha 19
cell adhesion molecule 19
B12 19
renin 19
CAR 19
FADS1 19
ATPase 19
myeloperoxidase 19
p38 19
ADP 18
Erythropoietin 18
ribonucleotide reductase 18
GTG 18
Dakar 18
CD4 18
antithrombin III 18
peroxidase 18
FABP3 18
alpha globin 17
LCE 17
membrane-bound 17
factor V Leiden 17
DGAT2 17
calmodulin 17
gamma chain 17
UTR 17
alpha-chain 17
natriuretic peptide 17
Pseudomonas 17
adipose triglyceride lipase 16
HO-1 16
histone 16
INSIG1 16
AST 16
kit 16
hereditary hemochromatosis 16
more...
Disease
sickle cell disease 11747
thalassemia 1474
SCD 1046
hemoglobinopathies 809
anemia 804
stroke 778
acute chest syndrome 500
cancer 407
hemolytic anemia 306
malaria 280
diabetes 272
pulmonary hypertension 265
iron overload 238
priapism 216
hypertension 215
ischemia 214
renal disease 191
osteomyelitis 182
sepsis 179
leg ulcers 159
sickle cell crisis 157
thalassemia major 152
chronic pain 148
West 147
cystic fibrosis 136
genetic disorder 134
sepsis 132
gallstones 131
dehydration 129
HIV 129
asthma 129
retinopathy 113
beta thalassemia 111
HBB 109
HBB 109
HBB 109
pneumonia 108
depression 107
infectious diseases 104
graft-versus-host disease 103
tumor 102
blood disorder 101
obesity 98
leukemia 98
meningitis 89
hereditary spherocytosis 84
heart failure 84
renal failure 78
atherosclerosis 78
cold 78
iron deficiency 78
proteinuria 77
parvovirus 70
malnutrition 69
FAS 67
immunodeficiency 65
myocardial infarction 65
heart disease 65
moyamoya 63
systemic lupus erythematosus 62
G6PD deficiency 62
cerebral infarction 58
AIDS 58
myelodysplastic syndrome 58
haemophilia 55
thrombocytopenia 54
bacteremia 53
chronic renal failure 53
lung disease 53
cirrhosis 52
hereditary persistence of fetal hemoglobin 50
vascular disease 50
Haemophilus 49
aplastic anemia 49
cardiovascular disease 48
chronic disease 46
liver disease 46
cardiomyopathy 46
abortion 45
cognitive impairment 44
arthritis 44
fat embolism 44
Infection 44
tuberculosis 43
nephrotic syndrome 43
fatty liver 43
hepatitis 43
bacterial infection 40
pulmonary embolism 39
lymphoma 39
chronic myeloid leukemia 38
phenylketonuria 38
subarachnoid hemorrhage 38
alpha thalassemia 38
osteoporosis 37
coronary artery disease 37
renal insufficiency 36
iron deficiency anemia 36
thalassemia trait 36
cholestasis 36
Sickle cell trait 35
hepatitis B 35
neutropenia 35
paroxysmal nocturnal hemoglobinuria 34
microalbuminuria 34
myocardial ischemia 33
epilepsy 33
rheumatoid arthritis 33
deep vein thrombosis 33
hemochromatosis 33
hemosiderosis 33
addiction 32
infertility 32
SAD 32
septic arthritis 32
carcinoma 32
GSH 32
Alzheimer's disease 32
preeclampsia 32
dactylitis 32
congestive heart failure 32
influenza 31
ICD 30
vasculitis 30
multiple myeloma 30
hepatitis C 30
glomerulonephritis 30
acute myeloid leukemia 29
erythroleukemia 29
Gaucher disease 29
glomerulosclerosis 29
NAME 29
tricuspid regurgitation 29
transient ischemic attack 27
Adhesion 27
impotence 27
urinary tract infection 27
Mycoplasma 27
hypersplenism 27
thrombocytosis 27
erectile dysfunction 27
encephalopathy 27
hypogonadism 26
hyperbilirubinemia 26
Hodgkin's disease 26
Down syndrome 26
coma 25
sarcoidosis 25
respiratory failure 25
polycythemia vera 24
hyperlipidemia 24
obstructive sleep apnea 24
thrombocytopenic purpura 24
virus infection 24
alcoholism 23
lupus 23
myeloproliferative disorders 23
metastases 22
hyposplenism 22
migraine 22
more...
Symptom
pain 1063
acute pain 113
splenomegaly 110
analgesia 85
headache 74
abdominal pain 73
anesthesia 71
seizures 70
chest pain 50
hepatomegaly 42
bone pain 41
diarrhea 40
fatigue 39
respiratory distress 35
hypothermia 27
weakness 27
dyspnea 27
cough 24
collapse 24
back pain 24
erythema 23
pallor 23
stigma 22
vomiting 21
arthralgia 17
nausea 16
hip pain 13
shortness of breath 13
wheezing 12
discomfort 11
syncope 11
overweight 11
lethargy 11
discomfort 11
enuresis 11
hepatosplenomegaly 10
anorexia 10
thinning 10
hemiplegia 10
angina 9
acute abdominal pain 9
exhaustion 9
myalgia 9
decreased appetite 8
dizziness 8
low back pain 7
paresthesia 7
right upper quadrant pain 6
regurgitation 6
hyperoxia 6
vertigo 6
agitation 6
flank pain 6
snoring 6
Severe pain 5
hypercapnia 5
cancer pain 5
fever of unknown origin 5
tremor 5
Ill 5
knee pain 5
nausea and vomiting 5
Reticulocytosis 5
chills 5
spasm 5
ataxia 5
Depressive symptoms 5
insomnia 4
facial pain 4
distraction 4
acute abdomen 4
ENT 4
dark urine 4
paraparesis 4
exertional dyspnea 4
constipation 4
starvation 4
tachypnea 4
Sedation 4
polyuria 3
bedwetting 3
blurred vision 3
left upper quadrant pain 3
limb pain 3
catatonia 3
Neuropathic pain 3
pleuritic chest pain 3
tense 3
generalized pain 3
Decreased activity 3
epigastric pain 3
cyanosis 3
sleepiness 3
testicular pain 2
breakthrough pain 2
tinnitus 2
Physical findings 2
painful erections 2
prostration 2
shoulder pain 2
dental pain 2
Signs and Symptoms 2
orofacial pain 2
incoordination 2
numbness 2
periorbital edema 2
Postoperative pain 2
clubbing 2
leg pain 2
Other pain 2
hypoproteinemia 2
tonic-clonic seizure 2
chest tightness 2
Cushingoid 1
hopelessness 1
Anoxia 1
facial droop 1
metamorphopsia 1
abnormal gait 1
memory loss 1
Halo 1
acute stress 1
loin pain 1
tingling 1
acidity 1
sciatica 1
joint stiffness 1
PAIN 1
arm weakness 1
Pneumobilia 1
night sweats 1
heel pain 1
Thoracic pain 1
feeling tired 1
thigh pain 1
livedo 1
abnormal breath sounds 1
Cushingoid 1
spasticity 1
Respiratory symptoms 1
atypical chest pain 1
Scratch 1
Neurologic symptoms 1
cerebellar ataxia 1
polydipsia 1
cardiovascular impairment 1
growing pains 1
muscle stiffness 1
hemoptysis 1
dry eye 1
chorea 1
musculoskeletal disability 1
groin pain 1
Gastrointestinal symptoms 1
physical appearance 1
thoracic back pain 1
oliguria 1
nasal discharge 1
pelvic pain 1
body pain 1
more...
Drug
Cardiovasc 46
Asthma 30
Heme 26
vitamin E 24
ascorbate 23
lysine 23
Dermatol 23
Deferasirox 23
CSF 19
Dakar 18
CAM 14
Phosphatidylserine 14
Kenyan 13
DNase I 13
Nitric Oxide 13
ROS 12
VCR 10
NADH 10
IFN-gamma 10
MAP 9
G-CSF 9
IL-2 9
ROC 8
Vitamin E 8
ampicillin 7
Depo-Provera 6
Dial 6
Gel 6
Monit 6
CTX 6
EPI 5
Fluorescein 5
Senicapoc 5
Nephron 5
Desferal 5
Nephron 5
lactose 5
EPA 5
ENT 5
G418 5
THA 5
Ringer's solution 4
Poloxamer 188 4
nitroglycerin 4
PTH 4
Glutathione 4
Fluorescein 4
Desferal 4
Leaf 4
MDS 4
Albumin 4
Trental 4
Prednisolone 3
Mutagen 3
Eculizumab 3
Simvastatin 3
TAT 3
Norplant 3
niacin 3
Indomethacin 3
Vitamin A 3
CTX 3
CTX 3
AGG 3
Hydroxyethylstarch 3
Piracetam 3
pyridoxal phosphate 3
Spectrum 3
THF 3
Histamine 3
ALA 2
Bosentan 2
Domin 2
Luteinizing 2
ETA 2
CPR 2
Filgrastim 2
Cellulose acetate 2
Rutin 2
DM1 2
Orphan 2
TRM 2
Epoetin 2
DDAVP 2
Forskolin 2
Asn 2
CoCl2 2
Vitamin B 2
CoCl2 2
PFA 2
ABC 2
DDAVP 2
Alanine 2
Norplant 2
Gabapentin 2
TAK 2
Filgrastim 2
Eptifibatide 2
Biopolymers 2
CCL 2
Lovastatin 2
BH4 2
FAD 2
Camp 2
PTC 2
Glucose-6-Phosphate 2
Ouabain 2
Bosentan 2
Regadenoson 2
Bayer 1
CaCl2 1
Parkin 1
SBT 1
CaCl2 1
Aprotinin 1
Ora 1
Sulphasalazine 1
Moxifloxacin 1
Alteplase 1
Abatacept 1
Spectrum 1
K201 1
Tropicamide 1
Fansidar 1
Zileuton 1
Sodium acetate 1
Rimonabant 1
Salbutamol 1
Demerol 1
Alteplase 1
Frontal 1
Viagra 1
Levonorgestrel 1
Trenbolone acetate 1
Tenofovir disoproxil fumarate 1
DFP 1
Finasteride 1
Celsis 1
Darbepoetin alfa 1
DPA 1
Implanon 1
NBT 1
Aggrastat 1
Domperidone 1
CFS 1
HCG 1
Sodium Nitroprusside 1
Andriol 1
Viagra 1
LMWH 1
Alliance 1
GRF 1
Ketorolac 1
OTC 1
citric acid 1
TAC 1
Ethanol 1
Kollidon 1
Elmiron 1
Monensin 1
more...
Enzyme
lactate dehydrogenase 116
thrombin 79
aspartate aminotransferase 48
glucose-6-phosphate dehydrogenase 47
alkaline phosphatase 45
superoxide dismutase 44
catalase 42
alanine aminotransferase 42
protein kinase 41
peroxidase 37
endonuclease 37
mitogen-activated protein kinase 36
APC 36
ERK 35
LPL 31
arginase 29
AMP-activated protein kinase 28
ACS 27
luciferase 25
AMPK 24
CPT 24
NO synthase 24
AMPK 23
heme oxygenase 22
CPT 22
CPT 22
NADPH oxidase 22
ATPase 22
NADPH oxidase 21
focal adhesion kinase 20
glutathione peroxidase 20
renin 19
protein kinase C 19
phosphodiesterase 19
ribonucleotide reductase 18
ribonucleotide reductase 18
ACE 18
AST 16
acetyl-CoA carboxylase 15
BMT 15
methylenetetrahydrofolate reductase 14
methylenetetrahydrofolate reductase 14
guanylate cyclase 13
thromboplastin 13
xanthine oxidase 13
trypsin 12
DNA methyltransferase 12
tissue plasminogen activator 12
NOS 11
phospholipase A2 11
glutathione reductase 11
ceruloplasmin 10
glutathione S-transferase 10
adenosine deaminase 9
adenosine deaminase 9
RNA polymerase 9
reverse transcriptase 9
UDP-glucuronosyltransferase 8
proteasome 7
PDK1 7
hormone-sensitive lipase 7
peroxiredoxin 7
lipoprotein lipase 7
biotinidase 6
neuraminidase 6
pyruvate kinase 6
plasmin 6
glyceraldehyde-3-phosphate dehydrogenase 6
SNO 5
PKG 5
RNase 5
phosphoglyceromutase 5
RNase 5
MDP 5
aldehyde dehydrogenase 5
MEK 5
caspase-3 5
glyceraldehyde-3-phosphate dehydrogenase 5
creatine kinase 5
lipase 5
urease 4
glyceraldehyde-3-phosphate dehydrogenase 4
IKK 4
acyl-CoA dehydrogenase 4
CAD 4
CAD 4
fatty acid desaturase 4
nitrite reductase 4
CAD 4
nitrite reductase 4
DNase 4
glyceraldehyde-3-phosphate dehydrogenase 4
urease 4
thymidine kinase 4
acid phosphatase 4
cholesterol acyltransferase 4
citrate synthase 4
sphingosine kinase 4
nitrite reductase 4
Rex 4
sialidase 4
acyl-CoA oxidase 4
glyceraldehyde-3-phosphate dehydrogenase 4
cytosine deaminase 3
PRA 3
TAT 3
3-hydroxy-3-methylglutaryl-CoA reductase 3
CYP7A1 3
neutrophil elastase 3
phenylalanine hydroxylase 3
beta-galactosidase 3
PGM 3
adenylate cyclase 3
factor D 3
ALA synthase 3
chymotrypsin 3
CYP3A4 3
MIP 3
demethylase 3
acyl-CoA synthetase 3
dihydrofolate reductase 3
DNA polymerase 3
collagenase 3
enolase 3
prolyl hydroxylase 3
gamma-glutamyl transpeptidase 3
acyl-CoA synthetase 3
mu-calpain 3
AOR 3
PAH 3
prostaglandin synthetase 2
hexosaminidase 2
DAT 2
glucocerebrosidase 2
GTP cyclohydrolase I 2
ornithine aminotransferase 2
MAT 2
calcium pump 2
N-acetylglucosaminyltransferase 2
PRT 2
cytidine deaminase 2
CPR 2
NQO1 2
beta-glucuronidase 2
aldehyde dehydrogenase 2
paraoxonase 2
alpha-mannosidase 2
TGT 2
glutamate dehydrogenase 2
glutamate dehydrogenase 2
TdT 2
aldehyde dehydrogenase 2
CaMKII 2
glutamate dehydrogenase 2
protein methylase II 2
lecithin:cholesterol acyltransferase 2
C3b inactivator 2
MAT 2
glyoxalase II 2
alpha-galactosidase 2
more...
Compound
Clin 1118
Dec 785
oxygen 651
DNA 467
iron 446
Hemoglobin 366
Hydroxyurea 313
nitric oxide 308
calcium 147
water 146
sodium 142
glucose 110
creatinine 109
HBB 109
zinc 102
Benin 101
arginine 99
phosphate 93
CO2 71
potassium 69
Bantu 64
urea 62
acetate 61
Cardiol 60
TNF 57
valine 55
His 51
ATP 47
nitrogen 47
glutamine 46
glutamic acid 45
hydrogen 44
lysine 40
GSH 36
GSH 36
salt 34
SAD 32
MCH 30
nitrate 29
2,3-diphosphoglycerate 29
vitamin D 28
Heme 28
tyrosine 27
cysteine 27
ACS 27
ACS 27
cAMP 26
leucine 25
CoA 24
homocysteine 24
GTP 24
cGMP 24
ethanol 24
sulfate 22
CPT 22
CPT 22
copper 22
ADP 22
alanine 21
methionine 21
Phe 21
DPG 20
DPG 20
serine 19
ADP 18
ADP 18
glutamate 17
prostacyclin 17
butyric acid 17
EDTA 16
glycerol 16
Mg2+ 16
EDTA 16
threonine 16
PEG 16
aldehyde 15
MDA 15
aldosterone 15
DFO 14
Phosphatidylserine 14
retinol 14
NADPH 14
palmitic acid 14
galactose 14
aldehyde 14
NADPH 14
palmitic acid 13
Ile 13
phosphorus 13
SDS 12
NH2 12
DHA 11
Adrenal 11
Optimal 11
nicotinamide 11
PMA 11
N-acetylcysteine 11
ammonium 11
DHA 11
DHA 11
Hemin 10
Hemin 10
NADH 10
butyric acid 10
Hemin 10
Hemin 10
Cereb 10
H2O2 10
stearic acid 10
Clotrimazole 10
stearic acid 10
Gly 10
methanol 10
LCR 10
Insulin 10
acetic acid 10
Hemin 10
stearic acid 10
retinoic acid 9
Adenosine 9
CAT 9
Penicillin 9
ammonia 9
Asp 9
5-Aza-2'-deoxycytidine 9
ASA 9
Thrombin 9
DSM 9
Penicillin 9
CAT 9
CAT 9
pentose 8
Retinal 8
PEG 8
tryptophan 8
pentose 8
Vitamin E 8
Vitamin D 8
PGA 8
pentose 8
GMP 8
CAM 8
tryptophan 8
tryptophan 8
Ceftriaxone 8
tryptophan 8
TOF 8
MAP 8
selenium 8
butyric acid 8
Lactate 8
pentose 8
Morphine 7
Sodium 7
Fibrinogen 7
SSD 7
THP 7
NAD 7
THP 7
hydroxylamine 7
more...