Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002895 (
sickle cell disease
)
11,747
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cell-mediated immunity was evaluated in 26 patients with
sickle cell anemia
using skin tests for delayed hypersensitivity reactions. Patients with impaired delayed hypersensitivity reactions had lower zinc levels in plasma, erythrocytes, and neutrophils than patients with normal delayed hypersensitivity reactions or controls. The activity of
nucleoside phosphorylase
, an enzyme essential for T-lymphocyte function, was significantly lower in zinc-deficient patients with anergic
sickle cell anemia
. We conclude that zinc deficiency in patients with
sickle cell anemia
is associated with impaired delayed hypersensitivity. Decreased activity of
nucleoside phosphorylase
may be partially responsible for lymphocyte dysfunction in these patients.
...
PMID:Anergy, zinc deficiency, and decreased nucleoside phosphorylase activity in patients with sickle cell anemia. 640 57
