Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002895 (
sickle cell disease
)
11,747
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Serum immunoreactive prolyl hydroxylase protein, galactosylhydroxylysyl glucosyltransferase activity and the aminoterminal propeptide of
type III procollagen
were measured in 20 patients with
sickle cell disease
and the values were compared with those in 20 apparently healthy Nigerians. The means for the two enzymes and serum aminoterminal propeptide of
type III procollagen
were significantly higher in the
sickle cell disease
patients. Significant correlations were found between the values for the two enzymes and the protein serum aminoterminal propeptide of
type III procollagen
within the
sickle cell disease
patients. The data confirm that collagen formation is found in the liver, bone and other organs of patients with this disease. The measurement of serum immunoreactive prolyl hydroxylase protein, serum galactosylhydroxylysyl glucosyltransferase activity and serum aminoterminal propeptide of
type III procollagen
in prospective studies might be helpful in predicting hepatic, bone or diffuse fibrogenesis in
sickle cell disease
.
...
PMID:Serum enzymes of collagen synthesis and type III procollagen amino-propeptide in Nigerian patients with sickle cell disease. 301 43
Serum immunoreactive prolyl hydroxylase protein (S-IRPH), galactosylhydroxylysyl glucosyltransferase activity (S-GGT), and the aminoterminal propeptide of
type III procollagen
(S-Pro(III)-N-P) were measured in 20 patients with
sickle cell disease
and the values were compared with those in 20 apparently healthy Nigerians. The means for the two enzymes and S-Pro(III)-N-P were significantly elevated in the
sickle cell disease
patients. Significant correlations were found between the values of the two enzymes and the protein (S-Pro(III)-N-P) within the
sickle cell disease
patients. The data confirm that collagen formation is found in the bone, liver, or other organs of patients with this disease. The measurement of S-GGT and S-Pro(III)-N-P in prospective studies might be helpful in predicting general and hepatic fibrogenesis in
sickle cell disease
.
...
PMID:Serum enzymes of collagen synthesis and type III procollagen aminopropeptide in Nigerian patients with sickle cell disease. 301 72
