Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002895 (
sickle cell disease
)
11,747
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neonatal chondrodysplasia punctata (CDP) is characterized by epiphyseal stippling and midfacial hypoplasia. CDP is usually inherited, but can be acquired because of maternal
vitamin K deficiency
. We describe an infant with CDP born to a teenager with
sickle cell anemia
and transfusional iron overload. The mother had severe liver fibrosis, elevated liver iron concentration (34 mg Fe/g), and coagulopathy, but no gestational use of warfarin. Fetal abnormalities were attributed to
vitamin K deficiency
secondary to liver dysfunction from iron toxicity. Treatment of iron overload among women with
sickle cell anemia
of childbearing potential is important to avoid possible CDP in newborns.
...
PMID:Phenocopy of warfarin syndrome in an infant born to a mother with sickle cell anemia and severe transfusional iron overload. 2301 67
