Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002878 (
hemolytic anemia
)
7,530
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of the work was to determine the variation of UGT1A1 genotypes in patients with
hemolytic anemia
in the southern Brazil. Three hundred twenty-three patients with
hemolytic anemia
were genotyped for UGT1A1 along with 232 controls. Allelic and genotypic distribution did not differ among studied groups. The TA7/TA7 genotype presented a frequency that ranged from 3.2% to 18.0% (nonsignificant). Alleles
TA5
and TA8 were also found in the sample, even though southern Brazil is a major Caucasoid region. Genotype prevalence was very similar to those of African origins, reflecting the diversity of ethnic origins and the high degree of admixture in southern Brazil. Further studies should be conducted to correlate the modulating role of UGT1A1 polymorphism with the clinical conditions of each patient with
hemolytic anemia
.
...
PMID:Prevalence of UGT1A1 gene polymorphism in patients with hemolytic anemia in southern Brazil. 2127 55
