Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002878 (hemolytic anemia)
 7,530 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An evaluation of 433 children with thrombocytopenia is presented. The material comprises all cases diagnosed in Denmark during the period 1959-1969. The incidence was found to be 31.9 cases per 1,000,000 inhabitants less than or equal to 15 years of age per annum with a peak at the age of 3 to 4 years; the majority of the cases was diagnosed in the spring. Preceding infection, usually associated with fever and localized in the upper respiratory tract, was the most common cause. The majority of the congenital cases was hereditary and associated with other malformations involving in particular the immune system. In about half of the cases the course was spontaneous and no treatment was necessary; the remaining patients were treated with glucocorticoids, including 46 patients, who had undergone splenectomy. 22 patients died, including 16 cases due to serious underlying disorders; in 6 cases the cause of death was haemorrhage (mortality rat=1.4%). At the follow up the platelet count was below 50 mia/1 in 14 patients (4%). No difference was found concerning the platelet count at the follow up between the patients with spontaneous recovery, the patients treated with glucocorticoids and the patients, in whom splenectomy had been performed. During the course the disease autoimmune haemolytic anaemia occurred in 2 patients, whereas no patient developed systemic lupus erythematosus.
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PMID:Thrombocytopenia in childhood: an evaluation of 433 patients. 127 14

A 75-year-old woman, who had been on maintenance hemodialysis (HD) from 2000, was receiving erythro- poiesis stimulating agent (ESA) for renal anemia. In November 2013, although still continuing ESA, she was admitted to our hospital due to worsening anemia. Since blood tests suggested the possibility of hemolytic anemia, we consulted,with hematologists, and she was transferred to another hospital. Differential diagnosis for anemia revealed that she had newly developed Evans syndrome, which is the complication of autoimmune hemolytic ane- mia (AIHA) and idiopathic thrombocytopenic purpura(ITP). She was successfully treated for AIHA with blood transfusion and administration of steroids, and for ITP by eradicating Melicobacter pylort. Anemia is commonly seen in HD patients, and the majority of anemia cases are diagnosed as renal anemia; however, hemolytic anemia should be considered in order to make a differential diagnosis. There are few reports of Evans syndrome in HD, and the pathogenesis of Evans syndrome is largely unknown. Further accumulation of clinical reports is needed to clarify its etiology.
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PMID:[A case of Evans syndrome in a long-term hemodialysis patient]. 3062 Aug 9