Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002878 (
hemolytic anemia
)
7,530
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A 61-year-old female, followed-up for a metastatic breast cancer, was admitted in our institution with conjunctival icterus, asthenia and abdominal crampoid pain. The patient was included in a clinical trial comparing the efficiency of capecitabine monotherapy versus capecitabine conjugated with a new biological agent in a randomised and double blind trial. The patient was in the capecitabine alone arm. Biological tests performed upon admission suggested the diagnosis of
haemolytic anaemia
. Moreover, the direct Coombs test result was twice positive indicating autoimmune
haemolytic anaemia
.
Capecitabine
has been reported to cause haemolysis either alone or combined with lapatinib, each time with a mechanism other than immunological. In this clinical case, capecitabine is the most likely factor causing an autoimmune
haemolytic anaemia
.
...
PMID:Autoimmune haemolytic anaemia in a patient treated with capecitabine. 2396 25
