Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002878 (hemolytic anemia)
 7,530 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case is presented of a man with chronic active hepatitis who developed immune hemolytic anemia in the course of a prolonged treatment with Catergen/(+)-Cianidanol-3/Zyma (four therapeutic courses in two years). The possible mechanism of hemolysis during Catergen treatment are discussed. The most probable mechanism is the absorption of the drug on the erythrocytes. The Catergen fixation on the erythrocytes does not require any special structure connected with the blood group antigens. Probably the link is non-covalent since the drug is easily removed from the erythrocytes--for 10 min at 56 degrees C.
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PMID:[Immune hemolytic anemia caused by catergen]. 261 15

Recently, there has been a variety of reports of adverse drug reactions during therapy with the flavonoid Cianidanol (Ci), a cytoprotective radical scavenger, especially involving haemolytic anaemia and drug fever. To elucidate whether the fever was due to a direct, antigen-independent interaction of Ci with immune competent cells, its effect on macrophage (M phi) function and early biochemical events during lymphocyte activation has been examined. A direct interaction of Ci with M phi was demonstrated, resulting in increased secretion of interleukin-1 (IL-1). The influence of Ci on lymphocyte activation was assessed by measuring levels of cyclic AMP and GMP. At high concentrations of Ci, cAMP levels were increased, and at low Ci concentrations cGMP levels were elevated. Both findings are correlated with lymphocyte proliferation and function, which is increased at low and decreased at high concentrations of Ci. The synthesis of prostaglandin E2 by M phi, an important factor in M phi-mediated suppression, was reduced by increasing doses of Ci, which inhibited M phi-cyclooxygenase. Ci did not affect phospholipase A2 activity. These findings indicate that flavonoid-induced fever may be due to allergic as well as pseudo-allergic mechanisms, the latter probably caused by increased antigen-independent release of IL-1, the endogenous mediator of fever.
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PMID:The pathogenesis of cianidanol-induced fever. 284 Feb 92