Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002874 (aplastic anemia)
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Human Gene/Protein
140 AA 12.4
H4FN 11.4
HLA class II DRB1 antigen 11.4
DRS-1 11.1
PR domain containing 8 10.8
SLC25A39 10.4
Carcinoembryonic antigen-related cell adhesion molecule 8 10.4
PIG-A 10.4
TINF2 10.3
FAAP100 10.2
HLA DRB1 gene 10.1
Tp120 10.1
ACTBL2 10.1
HIST1H2BH 10.1
PIGA 9.6
DNAJC21 9.5
FANCE 9.5
GIMAP6 9.4
NHP2 9.4
NOLA2 9.2
NOP10 9.2
DKC1 9.2
Transcobalamin I 9.1
Formiminotransferase-cyclodeaminase 9.1
50 AA 9.1
GDNF family receptor alpha 1 9.0
GIMAP4 8.9
dyskerin 8.9
FAAP24 8.9
RAB20 8.8
FANCG 8.8
UNC-45A 8.8
SH2D1A protein 8.8
M-phase phosphoprotein 1 8.8
FANCF 8.8
GPI anchor biosynthesis 8.8
Ribosomal protein S19 8.7
SRP72 8.6
BCORL1 8.5
FANCB 8.5
SBDS 8.4
Dyskerin 8.4
FANCD1 8.4
putative E3 ubiquitin ligase 8.4
c-MPL 8.4
TCAB1 8.4
POLE2 8.3
FANCC 8.2
human leukocyte antigen A 8.2
RASA3 8.2
FANCA 8.2
SH2D1A 8.1
megakaryocyte growth and development factor 8.1
thrombopoietin receptor 8.1
C16orf57 8.0
SMAP1 8.0
CD55 8.0
MOG1 7.9
GNAI1 7.9
CD59 7.9
MPP1 7.9
SAA 7.9
TIN2 7.8
kinectin 7.7
PIG-M 7.7
OST48 7.7
hBUB1 7.6
HERPUD1 7.6
MAGT1 7.6
Nibrin 7.6
HLA-B61 7.6
thrombopoietin 7.6
MDS 7.5
chemokine (C-C motif) ligand 3 7.5
HLA-2 7.5
FANCJ 7.5
SAMD9 7.5
SAMD9L 7.5
FANCL 7.5
THPO 7.4
more...
Disease
Infection in marrow transplant recipients 12.4
Non-A, non-B, non-C hepatitis 12.4
erythrogenesis imperfecta 12.4
aplastic anemia 12.4
Drug-induced gynaecomastia 12.4
Drug-induced aplastic anemia 12.4
Revesz syndrome 11.5
Acute disseminated candidiasis 11.4
Megakaryocytic hypoplasia 11.4
von Willebrand disease type 2 11.4
Dihydrofolate reductase deficiency 11.4
Acute uveitis 11.4
Amegakaryocytic thrombocytopenia 11.0
Acquired aplastic anemia 10.8
Monosomy 7 syndrome 10.8
panmyelophthisis 10.7
congenital aplastic anemia 10.6
Secondary anemia 10.5
Candida granuloma 10.4
myelodysplastic anemia 10.4
congenital amegakaryocytic thrombocytopenia 10.3
paroxysmal nocturnal hemoglobinuria 10.1
stage IV chronic lymphocytic leukemia 10.1
Cutaneous toxoplasmosis 10.1
dyskeratosis congenita 10.0
Refractory heart failure 9.8
colon growth 9.8
gray syndrome 9.8
Polymorphic PTLD 9.8
Opportunistic mycoses 9.8
Idiopathic aplastic anemia 9.6
chronic undifferentiated schizophrenia 9.6
Congenital thrombocytopenia 9.6
Juvenile fibroadenoma 9.6
Compensated hypothyroidism 9.4
acquired hemolytic anemia 9.3
bone marrow disorder 9.2
Disseminated trichosporonosis 9.2
pancytopenia 9.1
Bacillus cereus infection 9.1
congenital hypoplastic anemia 9.0
Red cell aplasia 8.9
Transfusion related acute lung injury (TRALI) 8.9
FANCN 8.9
Neutropenic colitis 8.8
Neutropenic enterocolitis 8.7
Hyper IgM syndrome 8.7
nonmalignant hematologic disorders 8.7
hypoplastic anemia 8.5
Eosinophilic fasciitis 8.4
FANCD1 8.4
pyeloureteritis cystica 8.4
MDS-U 8.4
Idiopathic thrombocytopenia 8.4
VACTERL-H 8.3
Stenotrophomonas maltophilia infection 8.3
refractory cytopenia with multilineage dysplasia 8.3
myelodysplastic syndrome 8.2
neuroblastoma stage 8.2
RAEB-T 8.2
congenital immunodeficiency 8.2
Coombs positive hemolytic anemia 8.1
refractory anemia 8.1
hematological abnormality 8.1
Acute graft-versus-host disease 8.1
erythroblastopenia 8.1
Myelokathexis 8.1
Parvovirus B19 infection 8.1
Fanconi syndrome 8.0
reticular dysgenesis 8.0
Myelodysplastic Syndrome 8.0
Bone marrow depression 7.9
X-linked lymphoproliferative syndrome 7.9
EBV hepatitis 7.9
Littoral cell angioma 7.9
metaphyseal dysostosis 7.9
blood disorder 7.9
Chronic GVHD 7.9
severe congenital neutropenia 7.8
graft-versus-host disease 7.8
more...
Symptom
Inspiratory dyspnea 9.2
Spastic paraparesis 7.4
epigastric distress 6.8
dark urine 6.6
generalized abdominal pain 5.8
menometrorrhagia 5.1
pallor 5.0
intestinal bleeding 4.7
giddiness 4.7
giddiness 4.7
chills 4.3
lassitude 4.3
right lower quadrant pain 4.1
splenomegaly 4.1
right upper quadrant pain 4.0
bone pain 4.0
loss of taste 3.9
bladder pain 3.8
abdominal fullness 3.7
hepatosplenomegaly 3.6
sore throat 3.6
hepatomegaly 3.4
hyperesthesia 3.3
asthenia 3.3
abdominal cramps 3.3
swollen joints 3.3
ketonuria 3.3
personality change 3.3
hypoproteinemia 3.2
dental pain 3.2
Fluctuation 3.2
persistent cough 3.1
hypertonia 3.1
masculinization 3.1
acute abdominal pain 3.0
exertional dyspnea 3.0
fever of unknown origin 3.0
groin pain 2.8
erythema 2.7
rigors 2.7
consciousness disturbance 2.7
neuralgia 2.6
dry eye 2.6
abdominal pain 2.6
myalgia 2.5
paresthesia 2.4
dry skin 2.4
arthralgia 2.4
nausea 2.3
flank pain 2.3
Ill 2.3
nasal congestion 2.2
exhaustion 2.2
lethargy 2.2
facial pain 2.2
anorexia 2.1
shortness of breath 2.0
tonic-clonic seizure 2.0
weakness 1.9
vertigo 1.9
fatigue 1.9
cough 1.9
physical appearance 1.8
acute abdomen 1.8
colic 1.8
headache 1.8
dizziness 1.7
seizures 1.7
vomiting 1.6
cerebellar ataxia 1.6
oliguria 1.5
cyanosis 1.5
diarrhea 1.4
blurred vision 1.4
chest pain 1.3
stridor 1.2
nausea and vomiting 1.2
dysuria 1.1
discomfort 1.1
sleepiness 1.1
more...
Drug
Ancestim 11.4
Antithymocyte globulin 10.7
Mepartricin 8.9
Serum gonadotrophin 8.5
Zonegran 8.2
Carbatrol 8.2
Cefbuperazone 8.1
Remoxipride 8.0
Deferasirox 7.8
MDS 7.5
Campath 7.4
Campath 7.4
Interferon beta-1a 7.4
Fludarabine 7.0
Desmopressin acetate 6.9
Temodal 6.9
Eculizumab 6.8
MZM 6.6
Ambisome 6.6
AKM 6.6
Methylcellulose 6.5
Rufinamide 6.5
G-CSF 6.5
Daclizumab 6.4
Hyoscyamine 6.4
Rocephin 6.2
Timentin 6.2
LCM 6.2
LCM 6.2
Dilantin 6.1
Filgrastim 5.9
Fosphenytoin 5.9
TRM 5.9
Filgrastim 5.7
AmBisome 5.7
Hydroxyethylstarch 5.7
Syrup 5.6
Gabapentin 5.6
Ara-A 5.6
Dipyrone 5.5
CTRX 5.4
SBT 5.4
Vitamin K2 5.2
Diamox 5.1
Dalteparin 4.9
CSF 4.8
Abatacept 4.8
Pefloxacin 4.8
Micafungin 4.7
Entecavir 4.6
Entecavir 4.6
Methylprednisolone 4.6
Prednisolone 4.4
Fansidar 4.4
Voltaren 4.4
Acyclovir 4.4
CTX 4.3
Epoetin 4.3
Guanethidine 4.3
Clopidogrel 4.3
CPZ 4.1
EDR 4.1
Tacrolimus 4.0
Auranofin 4.0
Prednisone 4.0
Caspofungin 3.9
Amifostine 3.9
Hypaque 3.9
Zinat 3.9
IL-11 3.9
Ganciclovir 3.8
Tao 3.8
Trimethoprim-sulfamethoxazole 3.8
Zonisamide 3.8
CIA 3.8
Hydrochlorothiazide 3.8
Pemetrexed 3.7
Ipilimumab 3.7
Hypaque 3.7
Tocilizumab 3.7
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Enzyme
BMT 8.1
creatinine iminohydrolase 8.0
phosphoglycolate phosphatase 5.8
cysteine conjugate beta-lyase 5.1
pyridoxal kinase 4.6
thyroid peroxidase 4.6
iduronate-2-sulfatase 4.5
PRPP synthetase 4.5
microsomal epoxide hydrolase 4.3
phosphoglycerate kinase 4.3
caspase-11 4.0
caspase-11 3.9
caspase-4 3.9
matriptase 3.9
GLO 3.7
dihydropteridine reductase 3.7
HCS 3.7
caspase-4 3.7
STR 3.6
granzyme B 3.5
TdT 3.5
matriptase 3.4
TGT 3.4
CYP27A1 3.3
thiopurine methyltransferase 3.3
1-hydroxylase 3.2
15-hydroxyprostaglandin dehydrogenase 3.1
factor C 3.1
asparaginase 3.0
LPL 3.0
DAT 2.9
AGT 2.8
aryl hydrocarbon hydroxylase 2.7
PST 2.7
PHD 2.6
ALDH 2.6
CD13 2.6
ferrochelatase 2.6
MIP 2.5
diacylglycerol kinase 2.4
ALA synthase 2.4
carbonic anhydrase 2.3
TSA 2.2
AST 2.2
NQO1 2.1
phospholipase D 2.1
heparinase 2.1
sialidase 2.0
CD10 1.9
alanine aminotransferase 1.9
reverse transcriptase 1.9
aldehyde dehydrogenase 1.9
aldehyde dehydrogenase 1.9
aldehyde dehydrogenase 1.9
polo-like kinase 1 1.8
ricin 1.8
aldehyde dehydrogenase 1.6
aconitase 1.6
neutrophil elastase 1.4
methylenetetrahydrofolate reductase 1.3
methylenetetrahydrofolate reductase 1.3
aldehyde dehydrogenase 1.3
matrix metalloproteinase 9 1.3
soluble epoxide hydrolase 1.3
plasmin 1.3
peroxidase 1.3
gamma-glutamyl transpeptidase 1.3
aspartate aminotransferase 1.2
hypoxanthine-guanine phosphoribosyltransferase 1.1
adenosine deaminase 1.1
glucose-6-phosphate dehydrogenase 1.1
adenosine deaminase 1.1
thromboplastin 1.0
MDP 1.0
glutathione S-transferase 0.9
tissue plasminogen activator 0.9
carboxylesterase 0.8
protein phosphatase 2A 0.8
isocitrate dehydrogenase 0.8
P-glycoprotein 0.7
more...
Compound
Oxymetholone 10.1
Felbamate 10.0
2-phenyl-1,3-propanediol 9.4
Primobolan 9.4
Pipobroman 9.4
atropic acid 9.2
Norethandrolone 8.7
Aminorex 8.3
Diepoxybutane 7.8
Stanozolol 7.7
Cefozopran 7.5
Aminoantipyrine 7.4
Stanozolol 7.4
Stanozolol 7.3
Muconic acid 7.1
Benzene 7.1
Oxcarbazepine 7.1
Diamant 7.0
Ticlopidine 6.9
PPBP 6.8
Mephenytoin 6.8
Methazolamide 6.7
Vigabatrin 6.7
Flucloxacillin 6.4
Anisodamine 6.4
CD 3 6.3
Cyclosporine 6.3
N-phenylacetamide 6.2
DCVC 6.1
Carbimazole 6.1
Danazol 6.1
Thiamphenicol 6.1
Tiagabine 6.1
Busulfan 6.0
Methimazole 6.0
Canthaxanthin 6.0
Sisomicin 6.0
MTX 5.9
KTS 5.9
Nizatidine 5.9
TBI 5.8
Diacetoxyscirpenol 5.8
Phenylhydrazine 5.8
Topiramate 5.8
Lamotrigine 5.7
Oil Red 5.7
Reticulin 5.6
Procarbazine 5.6
Temozolomide 5.3
DNC 5.3
CHNS 5.2
Solu-Medrol 5.1
Etanercept 5.1
ITP 5.1
Methotrexate 5.1
Buthionine sulfoximine 5.1
Ethosuximide 5.0
PIH 5.0
CHNS 5.0
CHNS 5.0
hydroquinone 5.0
Nandrolone 5.0
CHNS 5.0
Trimethoprim 4.8
Zonisamide 4.7
HPP 4.7
CAA 4.7
Methylprednisolone 4.7
Aminoglutethimide 4.6
Ara-C 4.6
Sulfasalazine 4.6
Geigy 4.5
DRB 4.5
Ara-A 4.5
CAM 4.5
Lindane 4.5
Prednisolone 4.5
Levetiracetam 4.4
Acyclovir 4.4
Guanethidine 4.4
more...