Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002874 (
aplastic anemia
)
5,905
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Survivin is a member of the inhibitor of apoptosis protein (IAPs) family and considered to play a pivotal role in oncogenesis. We present the first report of
survivin
expression profile in myelodysplastic syndrome (MDS). Expression of
survivin
messenger RNA was evaluated by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in patients with MDS and acute myeloid leukemia (AML). Eleven out of 12 patients with refractory anemia (RA) (91.6%), and all 3 patients with refractory anemia with excess blasts in transformation (RAEBt) (100%), were positive for
survivin
expression with the majority of cases showing abundant levels of the
survivin
transcript. On the other hand, expression of
survivin
was undetectable in the 4 patients with chronic myelomonocytic leukemia (CMMoL). The level and frequency of
survivin
expression in patients with refractory anemia were compared to those in patients with AML. Out of 12 patients with de novo AML, 5 patients (41.7%) showed detectable levels of
survivin
expression. Abundant
survivin
expression in RA was also confirmed by immunohistochemistry. In contrast,
survivin
was almost absent in two cases with
aplastic anemia
. We propose that high levels of
survivin
expression can serve as a reliable diagnostic marker of RA in MDS.
...
PMID:Expression of the anti-apoptotic gene survivin in myelodysplastic syndrome. 1246 85
Patients with inherited bone marrow failure syndromes (IBMFS) are at increased risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), possibly related to cell cycle dysregulation. In a cross-sectional analysis of bone marrow from 77 IBMFS, 71 sporadic conditions (AML, MDS, acquired
aplastic anemia
) and 22 normal controls we found overexpression of p53 in IBMFS, AML, and MDS; of Ki-67 in IBMFS and AML; and of
survivin
in IBMFS compared with all other groups. The patterns of expression of cell cycle markers in IBMFS are thus distinct. Longitudinal studies will determine the diagnostic and prognostic significance of these findings.
...
PMID:Bone marrow cell cycle markers in inherited bone marrow failure syndromes. 1860 49
