Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002874 (aplastic anemia)
 5,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Normal and pathologic reticulin networks colored black by silver nitrate can be automatically quantitated by electronic image analysis. By using this technique, different parameters can be obtained, such as the average density, the surface of network meshes, the thickness of the fibers, the complexity of the reticulum, and the heterogeneity of the myelofibrosis distribution. All of these parameters were obtained in 83 osteomedullar biopsies of blood diseases (primary splenomegaly, chronic myeloid leukemia, polycythermia vera, acute leukemia, and aplastic anemia). We have shown that there is no relation between the different parameters obtained and the medullary richness, hematopoietic center, or patient survival. On the other hand, the histomorphometric parameters can be used to distinguish acute leukemia and chronic myeloid leukemia myelofibrosis, while the parameters in primary splenomegaly are shown to be very heterogeneous.
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PMID:[Quantitation of myelofibrosis in blood diseases by electronic image analysis (author's transl)]. 29 Sep 75

Prolonged central venous catheterisation is associated with a substantial risk of line related infection, which may be reduced when a chlorhexidine/silver-sulfadiazine coated catheter (ARROWgard Blue(TM)) is used in medical or surgical ICU patients. However, no data is available from severely immunocompromised patients. We therefore performed an initial exploratory study among patients with haematological malignancy, aplastic anaemia or bone marrow transplantation. The study was terminated after the 12th catheter insertion. Eight of 11 assessable catheters developed a notable degree of mechanical dysfunction, which directly led to catheter removal in 2 patients. Six of the 11 catheters were unstable. Catheter-related infection occurred in 5 instances. Only 1 catheter functioned normally and was unassociated with infection. The ARROWgard Blue(TM) catheter cannot be recommended for prolonged use in these patients.
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PMID:High incidence of line-related infection and mechanical failure of an antiseptic impregnated central venous catheter in highly immunocompromised patients. 912 42

1. The effect produced by the intravenous administration of collargol on the bone marrow of rabbits varies directly with the amount of collargol injected, and three fairly well defined stages could be recognized. (a) An initial stage after comparatively few and small doses, with erythrocytic and endothelial hyperplasia in the bone marrow and with evidences of this stimulation in the peripheral blood in the form of young erythrocytes and normoblasts. (b) An intermediary stage which followed the injection of larger amounts of collargol, and which was characterized by a predominant myeloid hyperplasia. (c) A final stage with marked bone marrow aplasia and with colloidal silver deposited in endothelial cells, as well as in clasmatocytes. This was associated with a high grade anemia with low color index, resembling aplastic anemia in its main features. This stage terminated fatally. 2. There was no evidence of injury to blood cells in the peripheral circulation. The erythrocytic bone marrow aplasia was present before any appreciable decrease of red blood cells was found in the peripheral blood. 3. The results were less clear-cut in a series of rats, but anemia of a similar type was produced in all animals when sufficiently large doses were injected. 4. Splenectomy did not alter the course in rats materially. 5. It is fair to conclude that the cause of the anemia produced may be sought in the deviation of the parental endothelial cell toward clasmatocyte formation at the expense of the development of erythrocytes. 6. It is suggested that the results may be offered in support of the theory of the endothelial origin of both clasmatocytes and red blood cells.
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PMID:EXPERIMENTAL BONE MARROW REACTIONS : I. ANEMIA PRODUCED BY COLLARGOL. 1986 43

In this work, silver-doped TiO2 (Ag/TiO2) nanoparticles were synthesized using a photodeposition technique. The prepared Ag/TiO2 nanoparticles were characterized using TEM, SEM, XRD, and EDX techniques. The characterization of Ag/TiO2 nanoparticles using SEM and EDX techniques revealed the dispersion of Ag metal on the surface of TiO2. The photocatalytic activity of Ag/TiO2 and bare TiO2 in the presence of ultraviolet irradiation was investigated in the removal of chloramphenicol (CAP) as an antibiotic. CAP is a broad-spectrum antibiotic exhibiting activity against both Gram-positive and Gram-negative bacteria, as well as other groups of microorganisms. However, it is, in certain susceptible individuals, associated with serious toxic effects in humans including bone marrow depression, particularly severe in the form of fatal aplastic anaemia. The effects of the operational factors, such as doping content of Ag, photocatalyst dosage and calcination temperature were evaluated in the catalytic activity of Ag/TiO2. The results showed that the photocatalytic efficiency of TiO2 nanoparticles for the degradation of CAP, can be significantly improved by deposition an optimum amount of Ag nanoparticles (0.96 wt%) in the calcination temperature 300 degrees C. It was found that 900 mg/L of Ag/TiO2 is the optimum dosage in the removal of CAP with 20 mg/L initial concentration. The highest removal efficiency of CAP (-100%) at the optimum conditions was observed in 20 min. A mineralization study under optimum conditions showed about 88% reduction in total organic carbon after 120 min of irradiation time.
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PMID:Photocatalytic degradation of chloramphenicol in an aqueous suspension of silver-doped TiO2 nanoparticles. 2419 48