Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002874 (aplastic anemia)
 5,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

T cell immunoglobulin mucin-3 (TIM-3) is recently described as a T helper 1 (Th)1-specific molecule, participating in the regulation of immune responses and the pathogenesis of Th1-driven diseases. The TIM-3 pathway, however, has not been investigated in acquired aplastic anemia (AA). In this study, we examined the expression of TIM-3 and interferon-gamma (IFN-gamma) at both transcript and protein levels in 29 acquired AA patients and in 31 controls. Increased mRNA expression of TIM-3 and IFN-gamma were observed in both peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells from AA patients and controls using quantitative real-time reverse transcriptase-polymerase chain reaction. An increase of TIM-3 expression on PBMCs was detected increased in AA patients by flow cytometry. An overproduction of IFN-gamma was determined in the sera from AA patients by enzyme-linked immunoassay. In addition, the expression of TIM-3 ligand, galectin-9, increased in PBMCs from AA patients. The results are the first human data to demonstrate the increase of TIM-3 expression in AA. The enhanced TIM-3 engagement by its ligand in AA patients may play an important role in the pathogenesis of this disease.
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PMID:Increased T cell immunoglobulin mucin-3 and its ligand in acquired aplastic anemia. 1848 14

T cell immunoglobulin and mucin domain-3 (TIM-3), originally identified as a T helper (Th) 1-specific type I membrane protein, plays a vital role in Th1 immunity and tolerance induction through interaction with its ligand, galectin-9. The binding of TIM-3 by galectin-9 serves to downregulate Th1 responses. Moreover, the regulatory function of TIM-3 has been extended to other cells, such as Th17 cells, CD4(+) CD25(+) regulatory T cells (Tregs), CD8(+) T cells and certain innate immune cells. Previous studies have acknowledged that the TIM-3 pathway is involved in the pathogenesis of several human autoimmune diseases, such as systemic lupus erythematous, rheumatoid arthritis and aplastic anaemia. Moreover, genetic data suggest a role for TIM-3 in human autoimmune diseases. However, in immune thrombocytopenia (ITP), a common Th1- and possibly Th17-biased autoimmune disorder, the role of TIM-3 has not been explored. Recently, our data have demonstrated that TIM-3 expression is reduced in ITP patients, and we have found a potential link between ITP and the TIM-3 pathway. In this article, we discuss and speculate on the role of the TIM-3 pathway in ITP.
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PMID:The role of T cell immunoglobulin and mucin domain-3 in immune thrombocytopenia. 2438 85