Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002874 (aplastic anemia)
 5,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two new cases of aplastic anemia possibly associated with Neptazane (methazolamide) are reported. Several previous authors, as well as the manufacturer of Diamox (acetazolamide) and Neptazane, have recommended routine blood counts for patients on carbonic anhydrase inhibitors. Four surveys are presented of current practices with regard to blood monitoring. These include authors of case reports, 40 academic ophthalmologists, 81 ophthalmologists in private practice, and 66 glaucoma specialists. The vast majority does not routinely monitor blood counts of patients on carbonic anhydrase inhibitors. The value of routine blood monitoring is questionable both because of (1) the idiosyncratic, non-dose-related mechanism of the dyscrasias and (2) the variability of the timing of their onset and development. Regular observation and questioning of patients for symptoms are thought to be preferable. The importance of a thorough history when assigning an etiology to a dyscrasia is noted.
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PMID:Blood dyscrasias and carbonic anhydrase inhibitors. 321 78

A 13-year-old boy and a 16-year-old girl both presented with headaches and nausea after they were diagnosed with severe acquired aplastic anemia. Both patients had symptoms and signs consistent with the clinical syndrome of pseudotumor cerebri including headaches, nausea, papilledema, and elevated intracranial pressure. Both patients were treated with therapeutic lumbar puncture and acetazolamide, which relieved their symptoms. Acetazolamide dosage was given while the patients underwent an immunosuppressive regimen. We hypothesize that the pseudotumor cerebri in these two pediatric patients was the result of an increased production of cerebrospinal fluid in response to anemia and that the removal of fluid and treatment with acetazolamide appear to be helpful in such cases.
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PMID:Pseudotumor cerebri in two adolescents with acquired aplastic anemia. 1246 22