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Disease
Symptom
Drug
Enzyme
Compound
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Target Concepts:
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Query: UMLS:C0002874 (
aplastic anemia
)
5,905
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aplastic anemia
(AA) is a T cell immune-mediated autoimmune disease. Overactivated CD8
+
T cells play a leading role in the pathogenesis of AA, which may be due to disbalance in costimulatory and coinhibitory signals in T cells. In this study, we firstly investigated the expression of OX40, 4-1BB, GITR,
ICOS
, CTLA-4, LAG-3, and TIM-3 on CD8
+
T cells from untreated patients with AA and healthy individuals (HIs) by flow cytometry. Moreover, we further analyzed the phenotype and functional characteristics of CD8
+
GITR
+
T cells to more fully assess the T cell activation dysfunction in AA. We for the first time demonstrated significantly decreased percentage of CD8
+
GITR
+
T cells in AA, and CD8
+
GITR
+
CTLA-4
+
T cells were significantly higher in patients with AA compared with HIs. Conversely, the percentage of CD8
+
GITR
+
granzyme B
+
and CD8
+
GITR
+
perforin
+
T cells in AA patients was significantly reduced. Our preliminary data illustrate that the CD8
+
GITR
+
T cell population might negatively regulate overactive T cell activation in AA.
...
PMID:CD8
+
GITR
+
T cells may negatively regulate T cell overactivation in aplastic anemia. 3246 57
