Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 746 schoolchildren of both sex (aged 7-15) were investigated in the community of Backa Palanka and Bac with the view to establishing reference hematologic values of the red lineage: Hemoglobin (Hgb) 135.3 +/- 20.4 g/l, erythrocytes (Er) 4.42 +/- 0.60 x 10(12)/L, hematocrit (HTC) 0.41 +/- 0.06, MCH: 30.5 +/- 2.7 pg, MCHC: 32.8 +/- 3.2 g/l, MCV: 93.2 +/- 5.4 fl. In only 7.3% of children hemoglobin values were below 114.8 g/l (1.5 SD) so that anemia did not represent a socio-medical problem in children aged 7-15 in the area investigated. With regard to the investigation of inherited abnormalities in the synthesis and structure of hemoglobin five children showed a persisting synthesis of fetal hemoglobin with the mildly augmented HbF values: 2.7%, 3.8%, 3.9%, 4.2% and 4.8% while the increase in HbA2 with the values for heterozygotic forms of thalassemia was found in four children thus accounting for 3.3%, 3.5%, 3.5% and 4.3%. It was concluded that although genetically induced anemias were rare they were nevertheless present in this region. They necessitated further epidemiologic studies which had been performed in the greater part of Yugoslavia but not in SAP of Vojvodina nor in the new location of SAP of Vojvodina.
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PMID:[Epidemiologic study of anemia in school children with special emphasis on hemoglobinopathies]. 264 97

Hematological indices were determined in a group of 427 elderly Chinese subjects over 60 years old; reference ranges were established after excluding subjects with hemoglobinopathies or diseases giving rise to anemia and those with values less or greater than 3 SD from the mean. The values were similar to those for elderly Caucasians. All the red cell indices were significantly higher in men than women, possibly reflecting the influence of androgens on bone marrow function. Previously reported age-related decline in hemoglobin, red cell count and hematocrit from studies of all age groups was not seen in men or women above age 60 years, but a fall in platelet count with age, which had not been previously reported, was observed. There were no age-related changes in any other indices. Reference ranges were lower for Hb, MCV, and MCH in men and women, compared to those derived from a study of Chinese of all age groups. The prevalence of anemia due to disease and hemoglobinpathies in this population was 6.4% in men and 6.3% in women.
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PMID:Hematological indices and the prevalence of anemia in an elderly Chinese population. 266 65

Clinical, hematologic and hemoglobin composition data on the first case of Hb 0-Arab in association with beta 0-thalassemia in Yugoslavia are reported here. The propositus was a 26-years-old female from Strumica who was admitted to the hospital for several times because of anemia, hepatosplenomegaly, occasional abdominal pains, malaise and fatigue. Laboratory results presented: Hb 10.0 g/dl, RBC 3.84.10(12)/L, PCV 0.260 l/l, MCV 68 fl, MCH 26 pg, reticulocyte count 1.8%, anisopoikilocytosis, polychromasis, numerous target cells, total bilirubin 2.1 mg/dl, (indirect 1.7 mg/dl), serum-Fe 32.3 microM/L. A starch gel electrophoresis of hemolysate provided evidence for the presence of abnormal hemoglobin (approximately 85%) and Hb F (approximately 15%); the Hb A was absent. Familial screening showed her father was heterozygous for the abnormal hemoglobin, whereas the mother was heterozygous for beta-thalassemia. In vitro biosynthesis disclosed a total absence of beta globin and reduced synthesis of beta x x and gamma globin. The alpha/beta x + gamma-globin ratio was 1.77 (normal, 1.0 + 0.1). Amino acid analysis revealed that lysine substituted for glutamic acid at the position one hundred twenty-one of the beta chain (= Hb 0-Arab or beta 121 Glu----Lys).
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PMID:[Hemoglobin O Arab in interaction with beta 0-thalassemia]. 273 98

An algorithmic approach to the diagnosis of anemias is presented. It starts with history, physical examination, and a basic laboratory program including erythrocyte morphology. On the basis of the reticulocyte count and MCH-value anemias are divided into hypo- and hyperregenerative as well as micro-, normo-, or macrocytic forms. Within these groups it is easy to diagnose common anemias by only a few laboratory tests. Rare forms of anemia will be recognized as such and diagnosed by special investigations.
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PMID:[Rational diagnosis of anemias]. 307 Mar 61

The implementation of a Primary Health Care system in Macau has created the need to study the prevalence of Congenital Anemias in the population to facilitate the planning of measures needed for their control. Blood samples from 3815 women attending the antenatal clinics were screened for beta-thalassemia using MCH values as the preliminary test, followed by quantitation of Hb A2 and Hb F. Isoelectric-focusing was used to screen 1091 cord blood samples for the presence of Hb Bart's. The prevalence of alpha- and beta-thalassemia carriers was found to be 6.2% and 3.6%, respectively.
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PMID:Congenital anemias in Macau. 320 6

Various haematological parameters were followed in a group of 47 Kenyan patients with visceral leishmaniasis during treatment and follow up. The WBC and platelet numbers were normal by the time of cure, the Hb level took longer to become normal. Red cells were microcytic and hypochromic. MCV and MCH increased during follow up but microcytosis persisted up to a year after cure. Low serum iron and transferrin concentration, low total iron binding capacity and normal to high serum ferritin levels were found in 10 patients and are consistent with 'anaemia of chronic inflammation'. Bone marrows of 15 patients before treatment were normo- to hypercellular with increased erythropoietic activity. Low haemosiderin content of the bone marrow was consistent with iron deficiency, but normalization of Hb without iron suppletion would argue against a major role of iron deficiency. Coagulation studies did not indicate diffuse intravascular coagulation. Splenomegaly seems the most important factor in the causation of the pancytopenia. Further studies of contributing factors and of the cause and mechanism of 'hypersplenism' are needed.
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PMID:Haematological investigations in visceral leishmaniasis. 381 Aug 41

As microcytic anemia is a feature of aluminium intoxication, we prospectively studied the hematologic effects of deferoxamine in 10 hemodialysis patients with aluminum-induced bone disease. Comparing the mean monthly results of a 4 month period before and during deferoxamine therapy, we observed an important decrease of the transfusion needs (alpha less than 0.025) and an increase of hematocrit (p less than 0.02), hemoglobin (p less than 0.02), MCV (p less than 0.02) and MCH (p less than 0.05); the number of red blood cells remained unchanged. Our results show that deferoxamine treatment of dialysis patients with aluminum bone disease can markedly improve their anemia, even in the absence of recent aggravation, microcytosis and hypochromia. They also suggest that aluminum could participate in the anemia of dialysis patients even if it is normocytic.
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PMID:Improvement of anemia with deferoxamine in hemodialysis patients with aluminum-induced bone disease. 407 95

Haematological indices, malarial parasitaemia, serum and red cell folate (SFA, RCF), serum vitamin B12 and haemoglobin (Hb) electrophoretic patterns were studied in 228 non-elite young Hausa primigravidae at less than 24 weeks of gestation. The study was conducted in the guinea savanna of Nigeria, where malaria is hyperendemic. Ninety-nine (43%) were anaemic (Hb less than 11.0 g dl-1). The commonest cause of anaemia was malaria, in 28% of all and 40% of anaemic subjects. Plasmodium falciparum was predominant; P. malariae was seen in 1.3% and P. ovale was not recorded. Parasitaemia was more frequent and more dense in the wet than the dry season. Iron deficiency was diagnosed in 18% of all and 25% of anaemic women; 14% of all patients were folate-deficient; high MCV and MCH correlated with anaemia, and low SFA was associated weakly with anaemia and malaria. Serum vitamin B12 was normal or high in all 145 in whom it was measured; 3% had congenital elliptocytosis, but this did not contribute to the anaemia. Sickle-cell trait was present in 26% and Hb-AC in less than 1%. Hb-AS was associated with significantly lower frequency and density of P. falciparum; this has not been demonstrated in pregnancy in Africa previously. However, the parasitological advantage was not reflected in any haematological advantage. The roles of malaria, folate-deficiency and iron-deficiency in the causation of anaemia in Hausa primigravidae will be defined further by a double-blind trial of antimalarial prophylactics, iron supplements and folic acid supplements.
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PMID:Anaemia in young primigravidae in the guinea savanna of Nigeria: sickle-cell trait gives partial protection against malaria. 638 38

The relative roles of the kidney and liver as a source of Ep in a fully compensated hemolytic state were investigated. A compensated hemolytic anemia was induced in rats by injections of PHZ over a 6-week period. Verification of a fully compensated hemolytic state was established by MCV, MCH, MCHC, BV, PV, CRCV, peripheral reticulocyte counts, and bone marrow counts. The kidneys and livers of the PHZ-injected rats were subjected to concurrent perfusion at weekly intervals over the treatment period and the perfusate assayed for Ep activity. The kidney was found to be the principal source of Ep during the earlier stages of the anemia and the liver became increasingly important as a source of Ep during the later stages as the anemia became progressively compensated. By the fifth and sixth weeks of treatment, when the anemia was fully compensated, the livers of the PHZ-treated rats were the principal source of Ep. During these last 2 weeks of treatment, the amount of Ep recovered from the renal effluents of PHZ-injected rats was no greater than that collected from the renal effluents of saline-injected rats. The data indicate that the liver is the primary, if not the only, source of the higher titers of Ep in the fully compensated hemolytic state induced in the rat by long-term PHZ treatment.
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PMID:Hepatic production of erythropoietin in a phenylhydrazine-induced compensated hemolytic state in the rat. 686 74

Serum ferritin (SF) was determined by an immunoradiometric assay in a heterologous antibody system in 184 children of different ages with and without hematologic or biochemical signs of disturbed iron metabolism. SF levels as determined by this assay were higher than with a homologous antibody system, allowing a reliable discrimination of iron deficiency and overload. In normal children SF increased with age. In latent iron deficiency all SF values were below the normal range, if patients with signs of infections, elevated serum transaminases or parenteral iron therapy were excluded. In anemia of chronic renal failure there was a wider range of values than in controls, especially in children on intermittent hemodialysis. Highest SF values were obtained in polytransfused children with thalassemia. Significant correlations were observed between SF on one hand and Hb, MCV, MCH and serum transferrin saturation on the other hand, except in children with chronic renal failure on conservative treatment. Under hemodialysis there was a significant relation to the number of blood transfusions given.
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PMID:[Serum ferritin in children with disorders of iron balance]. 711 57


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