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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A role in the pathogenesis of the anemia of chronic renal failure has been attributed to secondary hyperparathyroidism. An amelioration of anemia after subtotal parathyroidectomy has been described. In the present study, no correlation was found between the severity of anemia and the level of serum parathormone in dialyzed patients. Furthermore, in seven patients, no improvement of the anemia was observed after parathyroidectomy.
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PMID:Anemia and secondary hyperparathyroidism in chronically hemodialyzed patients. 44 8

An example of Kaposi's sarcoma with primary involvement of lymph nodes is reported. The patient, a woman, was admitted because of generalized lymphadenopathy and anemia. She was also known to have congestive heart failure of rheumatic origin. SMA-12 screening disclosed hypercalcemia on several occasions during her hospitalization. Levels of circulating parathormone and prostaglandins E2 and F were markedly increased. Total bone scan was negative for involvement by tumor. Electronmicroscopic examination of an involved lymph node disclosed secretory bodies in the cytoplasm of malignant cells and other cells, with clear indication of endothelial origin. The rarity of Kaposi's sarcoma with primary lymph nodal involvement in the United States is discussed. So far as is known by the authors, no example of Kaposi's sarcoma has been associated with hypercalcemia due to ectopic endocrine production.
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PMID:Primary Kaposi's sarcoma of lymph nods. 99 71

The seventh case in the world literature of primary hyperparathyroidism in a neonate is reported. This is the fifth case in which an autopsy was performed. The clinical and anatomic findings in all seven cases are reviewed and compared. Neonates with primary hyperparathyroidism show diffuse hyperplasia of the parathyroid glands. The bones show disturbed osteogenesis, bone resorption, and widespread fibrosis of the marrow cavities. Bony cysts are not appreciated. Pathologic fractures are common. Marked hypercalciuria or hyperphosphaturia is usually not observed, perhaps because the immature renal tubules fail to respond to the influence of excess parathormone. Aminoaciduria and anemia are commonly observed. The prognosis is grave, and the etiology of this syndrome remains unexplained.
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PMID:Primary neonatal hyperparathyroidism. Report of a case and review of the literature. 110 78

The dose of recombinant human erythropoietin (r-HuEpo) required to correct anemia of end-stage renal disease varies among patients. The possible factors that interfere with the responsiveness to r-HuEpo were not completely known. In 32 patients on regular hemodialytic treatment with marked anemia (Hb 5.6 +/- 0.7 g/dl), we evaluated circulating erythroid progenitor cells [burst-forming-unit erythroid (BFU-E)], erythropoietin, ferritin, folate and 1-84-parathormone levels before r-HuEpo therapy. In 12 patients, the aluminum levels after deferoxamine were also evaluated. The possible correlation between these factors and the response to r-HuEpo therapy was then evaluated. The number of circulating (c) BFU-E was highly variable (521 +/- 447 colonies/ml of blood; normal level 742 +/- 192) and does not correlate with erythropoietin, ferritin, folate, 1-84-parathormone or aluminum levels. A direct correlation between basal cBFU-E and the responsiveness to r-HuEpo therapy was recorded while no correlation was found with the other analyzed parameters. We hypothesized that low basal cBFU-E (interleukin-3 deficiency?) could reduce the response to r-HUEpo because of failure of this hematopoietic stem cell compartment to replenish the pool of more mature erythropoietic progenitor cells during the phase of accelerated maturation induced by r-HuEpo.
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PMID:Circulating burst-forming-unit erythroid and the responsiveness to recombinant human erythropoietin in patients on regular hemodialytic treatment. 143 6

This report deals with an unusual case of primary macroglobulinemia with hypercalcemia, chronic renal failure and systemic amyloidosis. In May 1990, a 63-year-old male was transferred to our hospital because of hypercalcemia (13.5 mg/dl) and renal failure. Clinical examinations showed anemia, macroglossia, lymph node swellings and hepatomegaly. Laboratory findings included Bence-Jones (kappa type) proteinuria (0.8 g/day), a monoclonal gammopathy of the IgM-kappa type (2.8 g/dl), a proliferation of lymphoid cells in the peripheral blood (5%) and the bone marrow (59.6%), and lymphomatous involvement of an inguinal lymph node. Serum creatinine concentration was 8.5 mg/dl. The serum levels of parathormone and vitamin D3 metabolites were normal. The roentgenogram of bones showed a compression fracture of the lumbar spine and systemic osteoporosis. The treatment included eel calcitonin, prednisolone and the CHOP regimen, followed by hemodialysis and plasmapheresis. The serum level of IgM increased to 4.6 g/dl. The patient died three months later and postmortem examination demonstrated marked systemic amyloidosis.
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PMID:[Primary macroglobulinemia with hypercalcemia, renal failure and systemic amyloidosis]. 146 88

Anemia, almost always found in patients with the end-stage chronic renal failure, had been first related to secondary hyperparathyroidism in 1934. Parathormone leads to anemia in different ways, one being the lowered osmotic resistance. The osmotic resistance of erythrocytes in 57 patients with a progressive stage of chronic renal failure treated at the Hemodialysis Unit of the General Hospital Osijek was examined. The aim of the study was to establish the relationship between osmotic resistance and parathormonal level. The average value of the osmotic resistance median (ORM) in erythrocytes of the patients with chronic renal failure (0.37 +/- 0.03) was lower than in healthy probands (0.39 +/- 0.02). The difference was statistically significant (p < 0.001). No correlation was found between the C-terminal parathormone and the average values of erythrocytic ORM in the whole group or in the subgroup of 7 patients with pathological values of erythrocytic ORM. In patients treated with calcium antagonists, the average erythrocytic ORM value was not significantly lower than in patients who were not on such medications. Allowing the assumption that active parathormone has a high share in the C-terminal parathormone, we conclude that the lowered osmotic resistance of erythrocytes is not necessarily found in patients with chronic renal failure.
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PMID:[Osmotic resistance in erythrocytes in patients with chronic renal insufficiency]. 166 8

Anemia almost always found in patients with end-stage chronic renal failure has long been known to be related to secondary hyperparathyroidism. Parathormone leads to anemia in different ways, one being the lowered osmotic resistance. In the present paper we report on the osmotic resistance of erythrocytes in 57 patients with a progressive stage of chronic renal failure treated at the Hemodialysis Centre of the Osijek General Hospital. The aim of our study was to establish the relationship between the osmotic resistance and parathormonal level. The average value of the osmotic resistance median (ORM) in erythrocytes of patients with chronic renal failure (0.37 +/- 0.03) was lower than in healthy probands (0.39 +/- 0.02). The difference was statistically significant (t = 2.93, p less than 0.01). No correlation between C-terminal parathormone and the average values of erythrocytic ORM in the whole group or in the subgroup of 7 patients with pathologic values of erythrocytic ORM was found. In patients treated with calcium antagonists, the average value of erythrocytic ORM was not significantly lower than in patients not on these drugs. Allowing the assumption that active parathormone has a high share in C-terminal parathormone, we conclude that the lowered osmotic resistance of erythrocytes is not necessarily found in patients with chronic renal failure.
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PMID:[Osmotic resistance in erythrocytes in patients with chronic kidney insufficiency]. 209 82

Echocardiographic study of the left ventricle was performed in 57 selected, normotensive hemodialysis patients in comparison to 40 healthy controls matched for sex, age and blood pressure. The statistically significant abnormalities in uremic patients were an enlargement of the left ventricular end-diastolic diameter (LVEDiD) (5.58 +/- 0.60 vs. 5.05 +/- 0.5 cm; P less than 0.001) and an increase in the left ventricular radius to posterior wall-thickness ratio (r/Th) (3.65 +/- 0.68 vs. 3.27 +/- 0.44; P less than 0.001). Enlargement of the ventricle was related to anemia (P less than 0.001) and the hemodynamic effect of arteriovenous fistula. Ventricular radius to wall thickness ratio was inversely related to systolic arterial pressure in controls (P less than 0.001) and patients (P less than 0.01) with a significant upward shift of the regression in dialysis patients (P less than 0.001). In dialysis patients, the left ventricular posterior wall thickness (LVPWT) was inversely correlated to serum parathormone (PTH) level (P less than 0.001), and r/Th ratio was positively correlated to serum PTH (P less than 0.001). Bone biopsy was performed in 28 patients. Histomorphometric indexes of osteitis fibrosa were in dialysis patients, correlated to echocardiographic abnormalities; osteoclasts number was inversely correlated to LVPWT (P less than 0.001) and positively related to r/Th ratio (P less than 0.001). Osteoclastic resorption surfaces and LVPWT were inversely correlated (P less than 0.001), while a positive correlation between r/Th ratio and osteoclastic resorption surfaces was observed (P less than 0.001). Osteoblastic surfaces and tetracycline double-labeled surfaces were also correlated to LVPWT (P less than 0.001) and r/Th ratio (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Uremic cardiomyopathy: an inadequate left ventricular hypertrophy. 295 25

Erythrocytes from children with uremia who are undergoing hemodialysis show normal maximal velocity of NA+-Li+ countertransport and Na+/K+/Cl- cotransport and normal intracellular sodium content. These aspects of intracellular sodium metabolism are not affected by dialysis. The normality of intraerythrocytic cation metabolism in children with uremia is associated with anemia, increased systolic and diastolic blood pressure, reduced body mass index, retention of solutes (urea, creatinine, potassium), a low triiodothyronine and thyroxine syndrome, and high parathormone levels.
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PMID:Intraerythrocytic cation metabolism in children with uremia undergoing hemodialysis. 359 50

Clinical and radiological studies of seven patients with autosomic recessive malignant osteopetrosis are presented. Diagnosis was established before the age of 3 months in six cases and at 7 months in one. In all cases the presenting signs were pallor and hepatosplenomegaly with associated neurological involvement in five. All patients had normocytic normochromic anemia, leucopenia and thrombocytopenia with features of extramedullary hematopoiesis. Radiological studies revealed increase in the density of bones with "mask" appearance of facial bones and diminished size of optic foramina. Long bones showed absence of normal trabeculae and anomalies in modeling with methaphiseal bands and "bone within bone" images. There was hypocalcemia and hypophosphatemia with slight increases in alkaline phosphatase; parathormone was normal. Clinical course was characterized by progressive pancytopenia, recurrent infections and neurological deterioration with convulsions, nistagmus and optic atrophy. Five out of the seven patients died after a median of 3 months, due to infections or haemorrhage. The patient diagnosed at 7 months of age presented bilateral optic atrophy and moderate anemia; no other complications appeared after 2 year follow-up. Histological findings included substitution of bone marrow by chondro-osseous tissue; focal obsteoblastic and osteoclastic activity in calcified cartilage, and myeloid metaplasia in liver, spleen, lymph nodes and kidneys. The lesions are in agreement with the concept of a defect in bone formation-resorbtion balance; dysfunction of both osteoclasts and osteocytes is implicated in the pathogenesis. Unlike experimental disease, osteopetrosis in man is probably an heterogeneous disease and appropriate therapy should be individualized. Nevertheless, at present, the only favorable results have been obtained with bone-marrow transplantation.
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PMID:[Juvenile malignant osteopetrosis. Clinico-radiological study of 7 cases]. 663 10


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