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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was designed to investigate the usefulness of serum ferritin determinations for the diagnosis of cervical squamous cell carcinoma. The origin of ferritin in the circulation of these patients was also studied by an in vitro incubation system. Ferritin levels were determined by a radioimmunoassay kit (SPAC kit, Daiichi Radioisotope Lab.). Pretreatment serum ferritin levels were significantly higher (p less than 0.05) in patients with cervical squamous cell carcinoma, ovarian carcinoma, hepatitis and anemia than in normal women. All cases with endometrian cancer showed normal ferritin levels. Among patients with cervical squamous cell carcinoma, stage IV and recurrence groups showed higher ferritin levels than other stages. In vitro incubation studies revealed that squamous cell carcinoma could release significantly larger amount of ferritin than normal squamous epithelium. In addition, circulating and tissue ferritin of squamous cell carcinoma had the same immunological behavior in a ferritin radioimmunoassay, and also showed the identical localization on isoelectrofocusing gels. These results indicated that (1) circulating ferritin in patients with squamous cell carcinoma would, at least in part, be derived from the tumor tissue, and (2) serum ferritin determinations would be useful for the management of patients with cervical squamous cell carcinoma.
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PMID:[Ferritin levels in patients with cervical squamous cell carcinoma (author's transl)]. 723 35

Ferritin concentrations in cord blood were determined in 22 normal term and 32 preterm infants (birth weights 600-2000 g). Eight of the preterms were SGA infants. AGA preterm infants had significantly lower concentrations than term infants, and the SGA preterm newborn had even lower levels. Plasma ferritin in cord blood of the term and AGA preterm infants correlated positively with plasma iron and transferrin saturations, but not with the transferrin level, while plasma iron and transferrin concentrations correlated positively. In a longitudinal study, 17 AGA preterm infants (birth weights 850-1500 g) were followed during the early anaemia of prematurity. Iron was supplemented from 4 weeks of age. Plasma ferritin rose rapidly during the first days after birth, peak levels being reached at 1-4 weeks. Thereafter linear falls (semilog) occurred with similar slopes in different infants. Transferrin concentrations showed a slow progressive increase from 0-8 weeks. Plasma ferritin, after reaching the peak value, correlated negatively with weight gain. No infant had low ferritin values indicating iron deficiency during the early anaemia.
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PMID:Plasma ferritin concentrations in preterm infants in cord blood and during the early anaemia of prematurity. 723 84

Ferritin has been administered in immediately bioavailable solution form, and in solid form, with exclusively duodenal bioavailability, to two groups of patients suffering from sideropenic dyserythropoietic anaemia. The results obtained point to a significant stimulating action on erythropoiesis documented by the increase in reticulocytes and red cells. This increase is certainly relatable to the increase of available iron and to its incorporation in the erythrocytes, as demonstrated by the increase in ferritinaemia, sideraemia, haemoglobin and mean corpuscular haemoglocbin concentration. The data obtained showed the bioavailable fluid form to be more active than the solid.
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PMID:[Evaluation of hematometric parameters and plasma ferritin levels in patients treated with ferritin-containing preparations]. 725 24

Ferritin estimations were performed in serum from 38 Ethiopian and 10 Swedish pregnant women and in cord blood from their newborn infants. The mean ferritin level in the Ethiopian mothers was significantly higher than in the Swedish mothers as well as in a non-pregnant population of apparently healthy Swedish women. The Ethiopian mothers consisted of two groups with different economic situations, a privileged and a non-privileged group. The non-privileged group consumed the iron-rich traditional diet unique for Ethiopia, whereas some of the privileged mothers had abandoned this menu in favour of more refined food items with a lower iron content. Subnormal ferritin levels, indicating iron depletion, were found in 33% of the privileged and in 8% of the non-privileged group, in spite of the fact that the infants of the privileged group had a significantly higher mean birth weight, indicating a better nutritional standard in general. It is concluded that the previously reported rarity of gestational anaemia in Ethiopia is due mainly to the good iron state of Ethiopian women, especially those who still eat the traditional cereal bread. no correlation was found between maternal and cord blood ferritin. The relevance of cord blood ferritin in the diagnosis of the iron state is discussed.
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PMID:Serum ferritin in Ethiopian mothers and their newborn infants. Relation to iron intake and socio-economic conditions. 734 90

Renal cell carcinoma (RCC) has been shown to secrete several hormones and biologically active substances that influence the host metabolism or induce paraneoplastic syndromes. Observation of anemia in 20% of patients with RCC and the spontaneous recovery of anemia following nephrectomy drew attention to the body iron metabolism. Ferritin was previously proposed as a tumor marker for RCC. In order to determine whether RCC cells actually produce ferritin, we studied ferritin levels in serum from peripheral and renal veins as well as from the tumor tissue and the healthy parenchyma from radical nephrectomy specimens of 22 patients with RCC. Ferritin levels both in sera and cytosols were measured by an enzyme immunoassay method. The mean serum ferritin level from the renal vein was 419.9 +/- 72.4 ng/ml, and it was 157.3 +/- 18.3 ng/ml from the peripheral vein (p < 0.05). Renal vein ferritin correlated with stage and had a significant impact on prognosis (p < 0.05). The mean cytosolic ferritin level of the cancer tissue was 705.6 +/- 56.9 ng/mg cytosol protein, whereas in the normal parenchyma it was 95.9 +/- 10.1 ng/mg cytosol protein. This was also highly significant (p = 1.15 x 10(-13)), suggesting that RCC cells probably express ferritin. As currently there exists no reliable tumor marker for RCC, the value of ferritin as a marker should be investigated further before drawing any clinical conclusions.
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PMID:Ferritin: a tumor marker expressed by renal cell carcinoma. 852 38

Ferritin and soybean meal were reevaluated as dietary treatments of iron deficiency in rats. Isotopes that had been used in the past were avoided because of contemporary knowledge of the physiological and structural complexity of ferritin protein and the solid iron mineral. Rats made anemic by iron-deficient diets were given equivalent amounts of iron as FeSO4, horse spleen ferritin, baked soybean meal, or soybean meal plus ferritin. Full recovery (89-109%) from anemia and increased tissue iron occurred after 28 d of treatment with any of the iron sources, which contrasts to past bioavailability studies using 59Fe-labeled ferritin and generally shorter periods of observation. Cultivar-specific variability was observed in soybean seed soluble iron and ferritin content (1.9-2.0 times the control cultivar, Arksoy), which was apparently heritable. The combined data suggest that manipulating ferritin expression and other soluble components of seed iron in soybeans and possibly other seeds, using Mendelian and biotechnological approaches, could contribute to a sustainable solution to global problems of iron deficiency.
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PMID:Purified ferritin and soybean meal can be sources of iron for treating iron deficiency in rats. 855 96

We demonstrate that simple correlation between the various tests of iron status is not sufficient for examining their value in diagnosing iron deficiency (ID). Three degrees of ID are recognized: Iron depletion (ID grade I) is defined by decreased total body iron and normal iron support to erythropoiesis, as diagnosed by decreased storage iron, decreased ferritin, normal sideroblast count, normal zinc protoporphyrin (ZPP), and transferrin saturation >15%. When the iron supply to erythropoiesis becomes insufficient, as diagnosed by transferrin saturation < or = 15%, increased ZPP, and decreased sideroblast count, iron-deficient erythropoiesis (ID grade II) occurs. When finally hemoglobin is below its normal range, iron-deficiency anemia (ID grade III) results. The various tests for ID cannot be compared without taking into account the severity of the deficiency. Depending on the grade of ID examined, the correlation of markers seen in our patients' data varied considerably. We conclude that a "best" marker of ID does not exist. However, the different tests efficiently complement each other by detecting different stages and individually show the clinical extent of ID. Ferritin reflects the iron stores. ZPP indicates whether the ID in a given patient is clinically relevant or not. Finally, the extent of a clinically relevant ID can be assessed by the measured ZPP, hemoglobin concentration, and red cell indices.
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PMID:Laboratory tests of iron status: correlation or common sense? 896 57

We retrospectively reviewed the charts of 120 patients who received an initial prescription of iron from a resident physician in internal medicine to determine how accurately house officers diagnose iron-deficiency anemia before initiating iron therapy. Each patient's laboratory records were reviewed for the 3-month period before the prescription. Of the 120 patients, 77 (64%) did not have any iron tests performed to aid in the diagnosis of iron-deficiency anemia. Forty-three percent of those who had iron tests did not have the disorder by our criteria. Ferritin levels and iron profiles are often not measured in patients prescribed iron, and when they are, they are frequently misinterpreted by medical house officers. This can lead to inappropriate gastrointestinal procedures as well as inappropriate prescribing of iron.
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PMID:Appropriateness of iron prescribing: a retrospective study. 872 10

The authors compared the effect of recombinant human erythropoietin (rhEPO) in combination with iron with that of iron therapy only in the treatment of postpartum anaemia. Ninety patients (30 patients/group) received either rhEPO (300 U kg-1, i.v. or s.c., once) and iron (parenteral and oral), or iron therapy only. Erythropoiesis was assessed by haemoglobin and haematocrit increase, absolute reticulocyte counting and reticulocyte flow cytometry. Ferrokinetics was assessed by serum ferritin, transferrin and transferrin saturation measurements. There was no difference before therapy for baseline haematological values or iron status. Patients with endogenous EPO levels below 145 mU mL-1 had a significant benefit from intravenous rhEPO administration with highest haematocrit and haemoglobin levels 4 and 14 days after therapy. rhEPO-treated groups showed a higher absolute reticulocyte count 1 and 4 days after therapy and an elevated percentage of high fluorescent reticulocytes (HFRs). Parenteral iron therapy caused a significant increase of ferritin and transferrin saturation, while transferrin concentration decreased. Ferritin and transferrin levels were lowest after i.v. administration of rhEPO, 1 and 4 days after therapy. C-reactive protein concentration was highest in patients who underwent caesarean section until the end of the observation period. A single dose of rhEPO in combination with iron was more effective in treating postpartum anaemia than iron therapy only, in patients who had low EPO levels despite peripartal blood loss. Postpartum low endogenous EPO levels might be a consequence of inhibiting inflammatory cytokines that are released after spontaneous or operative deliveries.
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PMID:Use of recombinant human erythropoietin in combination with parenteral iron in the treatment of postpartum anaemia. 890 21

During April-May 1990 in Taiwan, health workers collected 10 ml venous blood samples from 371 school children 7-12.9 years old and from 352 adolescent students 13-19.9 years old attending primary, junior high, and senior high schools in Pingtung County and Taichung County. The researcher aimed to determine the iron status and prevalence of anemia in these children. Ferritin levels of less than 12 mcg/l defined iron deficiency. In both counties, girls were more likely to suffer from iron deficiency than boys. Teenage girls had the highest rate of iron deficiency (9.38% vs. 1.22-2% in Pingtung and 26.4% vs. 0-2.17% in Taichung). Among school children 7-12.9 years old in Pingtung, 2% of the boys in Pingtung and 3.33% of girls had iron deficiency. In Taichung, 0% of boys and 2.17% of girls had iron deficiency. Among the teenagers in Pingtung, 1.22% of the boys and 9.38% of girls had iron deficiency. These rates in Taichung were 0% and 26.4%, respectively. Less than 2% of all children had iron deficiency anemia. Among school children 7-12.9 years old in Pingtung, the anemia rate was 5% for boys and 5.56% for girls. In Taichung, 3.37% of the boys and 1.09% of girls had anemia. Among teenagers 13-19.9 years old in Pingtung, 3.66% of boys and 8.33% of girls had anemia. In Taichung, the anemia rate was 3.45% and 5.75%, respectively. These findings show that teenage girls are more likely to have iron deficiency than males. Thus, health officials need to develop an effective nutritional intervention and health care for youths to improve their iron status.
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PMID:Iron deficiency and anemia in school children and adolescents. 891 58


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