Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

16 chronic haemodialysis patients (group I), with non-microcytic anaemia (mean haemoglobin 7.2 g/dl, SD 1.0, range 5.8-9.8), moderate aluminium overload (serum aluminium 44 micrograms/l, SD 16, range 21-74), and normal or high iron stores (ferritin 800 micrograms/l SD 464, range 34-2013) were treated with intravenous desferrioxamine 1 g at the end of each dialysis for six months. 8 patients with similar characteristics served as controls (group II). After six months group I showed a rise in haemoglobin to 9.1 (SD 2.5) g/dl and a decrease in blood transfusion requirements, both significant, whereas group II showed no changes. Other significant changes observed in group I, but not group II, were a rise in reticulocytes and in red cell creatine and a fall in red cell protoporphyrin and serum ferritin. Ferritin decreased more in the patients whose anaemia improved. Minor increases in serum aluminium in group I did not differ from those in the control group. Desferrioxamine may benefit the anaemia of chronic haemodialysis patients through improvement of erythropoiesis. The effect seems not to be related to chelation of a heavy aluminium overload.
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PMID:Improvement in the erythropoiesis of chronic haemodialysis patients with desferrioxamine. 289 66

The present study was designed to evaluate the effect of an intensive physical training program involving both isometric and isotonic activities on the body iron status of 8 females and 11 males (age 20 +/- 1 year). The training was carried out over a 7 week period and included 8 h of varying physical activities each day. Venous blood samples were obtained from the subjects prior to the beginning of the training, on day 2 and in weeks 2, 4, 6 and 7 of the program. Blood samples were analyzed for iron, ferritin and hemoglobin (Hb) concentrations, total iron binding capacity (TIBC) and red blood cell count (RBC). Iron levels of males and females decreased 65% after 2 weeks of training (p less than 0.001). At the end of the training program 5 males and 6 females had lower than normal iron values (less than 13.4 mumol.l-1). TIBC increased 25% in women and 18% in men following 2 and 4 weeks of training (p less than 0.001) and remained at this elevated level throughout the training period. Ferritin levels decreased 50% in both sexes after 4 weeks of exercise (p less than 0.05) and remained at this level until the end of the training. Hb and RBC decreased 8-10% in both sexes during the training period. In two of the women anemia occurred after 4 weeks of training. The development of latent iron deficiency in a substantial number of participants after a relatively short period of training is uncommon and may reflect the high intensity of exercise required in this program.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Iron deficiency caused by 7 weeks of intensive physical exercise. 334 87

59 patients with active pulmonary tuberculosis were evaluated in terms of haematological indices, iron-related measurements and markers of inflammation. The variables evaluated included the Hb, mean cell volume (MCV), serum iron, total iron-binding capacity, percentage saturation, serum ferritin, erythrocyte sedimentation rate (ESR) and C-reactive protein. In addition, marrow iron stores were assessed both histologically and chemically. Among the changes noted was a raised S-Ferritin, which appeared in part to be a component of the acute phase response, since it correlated with C-reactive protein concentration (r 0.59, p less than 0.0001). In addition, there was a good correlation between the S-Ferritin and the concentrations of non-haem iron in the marrow, as assessed chemically on trephine biopsies (r 0.78, p less than 0.0001) and histologically on aspirated and biopsy material (rS 0.78, p less than 0.0001 and rS 0.68, p less than 0.0001, respectively). Furthermore, the quantitative relationship between the S-Ferritin and the chemical concentrations of non-haem iron in the marrow was similar to that found previously in a heterogeneous group of subjects without infections. While the present findings confirm that iron is diverted into reticuloendothelial stores in active pulmonary tuberculosis, no evidence was found to suggest that the anaemia which was present in 45 of the 59 patients was secondary to iron-deficient erythropoiesis; the percentage saturations in the 2 groups were 30.3 and 31.1 respectively. In a final analysis, the present findings were compared with previous ones obtained in a group of patients with Hodgkin's disease. The degree of rise in the S-Ferritin for a given marrow non-haem iron concentration was significantly less in the patients with tuberculosis (p less than 0.0001).
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PMID:Haematological and iron-related measurements in active pulmonary tuberculosis. 370 52

Blood hemoglobin and serum ferritin levels were measured at the initial visit and 12 months after sterilization and IUD insertion. Ferritin levels were unaltered in Progestasert users after 12 months but hemoglobin values increased though not significantly. Ferritin levels fell in Multiload Cu250 users and in sterilized women; hemoglobin levels were also observed to fall but were significant only in the latter group. Iron deficiency anemia was prevalent at initial contact and there appeared to be an increased risk subsequently in Multiload Cu250 users and in those who were sterilized. Screening and monitoring for anemia is indicated. From the viewpoint of iron status, the Progestasert is preferable to the Multiload Cu250 but it has the major disadvantages of needing frequent replacement and of causing menstrual disturbances which might compromise its acceptability. Menstrual blood loss studies may help explain why anemia develops after sterilization.
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PMID:Effect of laparoscopic sterilization and insertion of Multiload Cu 250 and Progestasert IUDs on serum ferritin levels. 666 21

The relationship between the level of erythropoiesis and iron balance was evaluated in 13 subjects with idiopathic refractory anemias. Serum ferritin levels and bone marrow iron stores were increased only in those patients with ring sideroblasts, erythroid hyperplasia and ineffective erythropoiesis. The magnitude of the increase correlated with the duration of anemia and the degree of increase in the erythron iron turnover. Ferritin levels were not related to the severity of the anemia, indicating that increased iron stores did not represent a shift of iron from the erythron or an absorption response to anemia per se. It does suggest that the level of erythroid proliferation directly affects gastrointestinal iron absorption, which in time leads to iron overload.
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PMID:Serum ferritin in refractory anemias. 679 92

Determination of serum ferritin is an important means of assessing body iron stores. Trace amounts of ferritin normally present in serum are detectable by sensitive radioimmunoassay techniques or an enzyme immunoassay procedure. Ferritin normally accounts for no more than a very small fraction of the total iron in serum, but generally maintains a stable concentration that is proportional to the much larger pool of storage iron in tissues. The serum ferritin assay, in contrast to other measurements of iron status such as hemoglobin, serum iron and iron-binding capacity, can distinguish differences in iron stores within the physiological range. In iron deficiency anemia, the concentration is below 10 ng per ml. Increased concentrations (above 200 ng per ml) are found in conditions with increased iron stores. The information it provides is similar to that obtained from bone-marrow aspirates stained for iron. In contrast to the percent transferrin-saturation and concentration of erythrocyte protoporphyrin, ferritin concentrations become abnormal before exhaustion of mobilizable iron stores and before the onset of anemia. Serum ferritin also provides a practical means of assessing new programs of iron supplementation, since it reflects various degrees of iron deficiency and overload.
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PMID:The measurement and interpretation of serum ferritin. 700 32

Ferritin, iron, total iron binding capacity and transferrin saturation were measured in the serum of 247 patients with microcytic hypochromic anemia. Differentiation into various categories of microcytic hypochromic anemia was based on clinical criteria and on the response to iron treatment. This produced 147 patients with iron deficiency anemia, 35 patients with anemia secondary to infection, 27 patients with anemia due to tumor and 38 patients with thalassemia. Analysis of the iron parameters revealed the reliability of both serum ferritin and transferrin saturation in distinguishing between the various forms of anemia. However, measurement of serum ferritin is slightly more reliable and much less expensive than determination of transferrin saturation.
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PMID:[The value of serum ferritin, serum iron and iron-binding capacity in the differential diagnosis of microcytic hypochromic anemia]. 705 13

Ferritin, iron status, and hematological parameters--Hb, hematocrit--were determined in 172 mature women at screening visits in first aid medical care units located in Senegal. Of the subjects 36.6, 39.5, 34.9% had Hb, hematocrit, and ferritin levels below accepted norms (i.e., Hb less than 11 g/dl, hematocrit less than 33%, serum ferritin less than 10 ng/ml). Serum iron level was normal (greater than 50 micrograms/dl) in 94.2% of the subjects, but 48.3% had marginal levels (51 to 100 micrograms/dl). The distribution curves of Hb level in the population indicates that about 58% of the women had Hb less than 12 g/dl. Furthermore, the very low serum ferritin levels (less than 20 ng/ml) encountered in 75.6% of subjects, demonstrate the small size of their iron stores. This precarious iron balance indicates that these women are at a high risk of nutritional anemia. Numerous factors such as pregnancy or parasitical infestation can dramatically modify this iron balance and increase the prevalence of anemia in this population.
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PMID:Ferritin and iron status in Senegalese women. 710 87

Concentration of ferritin in blood serum of dairy cows was measured by a two-site immunoradiometric assay to assess changes in the iron nutritional status during gestation, parturition, and lactation. Although anemia did not occur in pregnancy of dairy cows, there were slight decreases of red cell counts, hemoglobin, and hematocrit in the early stage of lactation. Ferritin concentration remained relatively constant in late gestation (35 ng/ml), but deviations were considerable. Ferritin rose gradually from 3 days prepartum with a sharp elevation after parturition. At 1 to 2 wk postpartum, it had increased to about twice amounts in late gestation. During the subsequent 8 wk postpartum, it fell gradually and thereafter maintained almost unchanged (40 ng/ml). Both iron in blood serum and total iron-binding capacity declined from 2 wk prepartum to the end of gestation but showed a rise beginning about 2 wk after parturition. Because changes in iron-related proteins just before and after delivery may be results of inflammatory reactions accompanying delivery, ferritin concentration is not a good index for diagnosis of iron deficiency in lactating cows just after parturition.
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PMID:Ferritin in blood serum of dairy cows. 714 30

Rheumatoid arthritis is a systemic disease in which anaemia is common. The origin of the anaemia is usually multifactorial. Iron deficiency, a defect of release of iron from the reticulo-endothelial system is discussed. Ferritin content of monocytes, lymphocytes and polymorphs is found altered and mostly elevated in monocytes affected by serum iron deficiency. In all cell types iron uptake is related to transferrin saturation. Alterations against normal subjects in iron uptake, ferritin synthesis and iron incorporation into ferritin are mostly found in patients with serum iron deficiency.
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PMID:Serum ferritin and iron uptake by peripheral blood leucocytes in patients with active rheumatoid arthritis. 718 34


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