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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quantitation of the erythropoiesis with radio-iron (59Fe) was applied to 9 patients with untreated myelomatosis. The method included blocking of the 59Fe reutilization by injection of non-radioactive iron. There was no uniform pattern in the Fe-kinetics values. The Plasma Iron Turnover (PIT) and the Red Blood Cell Iron Turnover (RBCIT) varied from subnormal to values markedly increased above upper normal limit. The calculated average Mean Red Cell Life time (MRCL) of erythrocytes was just below normal range. The mean Marrow Transit Time (MTT) was normal in the patients, despite subnormal venous haematocrit, indicating insufficient stimulation of the bone marrow. The renal function, measured as 51Cr-EDTA clearance, was found positively correlated to the RBCIT (r = 0.78, P less than 0.05). The results suggest that the previously demonstrated relationship between anaemia and renal failure in patients with myelomatosis is caused mainly by an inability of the bone marrow to produce sufficient red blood cells under the stress of anaemia related to the degree of renal impairment.
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PMID:Quantitation of erythropoiesis in myelomatosis. 47 59

The anaemia resulting from iron deficiency is described as hypochromic in the medical literature. In the veterinary literature, anaemia of veal calves is usually regraded as normochromic. In order to examine the correctness of this view, the present authors studied the Hb and haematocrit (Hc) levels of the blood of veal calves in a comparative feeding trial for sixteen weeks. Three groups of male Dutch-Friesian calves, each group consisting of approximately thirty animals, were fed a milk replacer which contained 5, 10 or 25 ppm of iron respectively. The calculated mean Hb-concentration in the erythrocytes of the animals given 5 and 10 ppm of iron dropped during the trial period to below levels occurring at the age of two weeks. In the group given 25 ppm of iron, the erythrocyte Hb showed a rapid increase from the age of ten weeks and continuing throughout the rest of the trial period. At the age of sixteen weeks, the groups showed significant differences (P less than 0.01) in their mean erythrocyte Hb-concentrations. In veal calves, fed milkreplacers having an iron content below 25 ppm of Fe, the anaemia therefore is hypochromic.
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PMID:[Is anaemia of veal calves normochromic or hypochromic? (author's transl)]. 47 44

One hundred consecutive patients with hemoglobin concentration less than 3.5 g/dL (hematocrit reading, less than 10%) were admitted to the University of Baghdad Teaching Hospital, Iraq, during a 30-month period. Twenty-eight patients had aplastic anemia, 27 had leukemia or other hemopoietic malignancies, 16 had chronic renal failure, eight had iron-deficiency anemia, eight had hemolytic anemia, seven had thalassemia major, and six had other conditions. Twenty-three patients died within seven days of admission, mostly due to the underlying disease or complications thereof. Heart failure developed in ten patients, and five had retinal exudates and hemorrhages attributed to severe anemia. Arrhythmias and ECG abnormalities were noted in 20 of 68 patients. Blood transfusion was instituted in all but three patients, whose anemia was corrected with specific therapy without blood transfusion. The tolerance of the 100 patients to such severe anemia was remarkable.
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PMID:Severe anemia. Clinical observations in 100 patients with very low hemoglobin levels. 47 23

The aim of this investigation was to establish the relationship of cadmium-induced fetal growth retardation in the mouse to iron deficiency. Pregnant mice were either fed a low iron diet or given 40 ppm cadmium in their drinking water. The effects of these factors on fetal weight and hematological values of the fetuses and dams were established and compared, both with each other and with appropriate controls. Both treatments caused maternal and fetal anemia, the fetuses being more severely affected. The anemic fetuses were also severely growth retarded. These changes, when caused by the iron deficient diet, could be completely prevented by either parenterally or orally administered iron supplements. When the changes were caused by cadmium in the drinking water they were only partially prevented by oral supplements. From these results it was concluded that iron deficiency in pregnancy causes not only anemia but also fetal growth retardation. Cadmium exposure in pregnancy, presumably by blocking intestinal absorption of iron, also causes anemia and hence fetal growth retardation.
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PMID:Iron deficiency and its role in cadmium-induced fetal growth retardation. 47 57

The responses of susceptible Ndama and Zebu cattle to needle challenge with Trypanosoma congolense were followed using parasitological, haematological and radio-isotopic methods and compared with those of corresponding uninfected animals. In both breeds, infection became patent at the same time but peak parasitaemias were significantly lower, were attained later and were of short duration in the Ndama. All infected animals became anaemic, the severity of which correlated with the level and duration of parasitaemia. However, even when parasites could no longer be detected in the blood, packed cell volumes showed little tendency to recover. The anaemia was due to increased intravascular red cell destruction and was more pronounced in the Zebu. Haemodilution was not a feature. Increased red cell syntheisis occurred in infected animals of both breeds but particularly in the Zebu; this accounted for the capacity to maintain packed cell volume levels following the initial drop associated with parasitaemia. However, in most cases red cell synthesis was less than expected from the degree of anaemia, suggesting impairment of bone marrow function. Measurement of red cell iron utilization indicated that this was due to effective from re-utilization from degraded red cells arising from reticulo-endothelial blockade. It is concluded that the anaemia in this disease and its underlying processes are broadly in line with the number of parasites in the blood and that the superior resistance of the Ndama cattle lies in their ability to control parasitaemia rather than their capacity to mount a more efficient erythropoietic response.
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PMID:Bovine trypanosomiasis: the red cell kinetics of ndama and Zebu cattle infected with Trypanosoma congolense. 48 5

Mortality and morbidity associated with the IUD -- already relatively low -- can probably be reduced to a minimum with greater awareness of the risks of IUD use. This assessment focusses on 4 main areas of concern: 1) Consequences of contraceptive failure. A unique feature of intrauterine contraception is that the morbidity of pregnancies due to failure of the method is increased by the method itself. When pregnancy occurs with the IUD in place, incidence of extrauterine pregnancy, spontaneous abortion, bleeding, and prmature and still births are increased, with the miscarriage rate up to 50% (compared to 10 to 20% in the general population). This latter incidence is steeply reduced if the IUD can be removed. 2) Pelvic infection. Many studies have shown increased incidence among IUD users, the consistency of reports indicating a causal relationship, especially worrying in that the highest risk is among young nulliparas. A variety of causes has been suggested. While infection cannot be completely eliminated, strict attention to antisepsis at insertion, recognition of early warning signals, and avoidance of use by high risk groups, should minimize the dangers. 3) Problems associated with insertion. A major concern is avoidance of perforation. Special care is needed when inserting a device up to 8 weeks after pregnancy. A perforated IUD should be removed -- copper-bearing devices may be especially risky. Laparotomy or minilap may be preferable to laparoscopy for removal of bioactive devices. Risks at insertion should be considered when prescribing medicated devices which require more frequent replacement. 4) Anemia. All IUDs have some effect on bleeding, most causing increased bleeding during menstruation and some intermenstrual bleeding and spotting. This has primarily been seen as a cause for discontinuation, but may have medical consequences in developing countries where iron loss cannot be easily made up nutritionally. A small but real risk from therapeutic practices (use of drugs and antibiotics to reduce side effects, and surgical procedures for removal of perforated IUDs) is also noted.
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PMID:The safety of intrauterine devices. 48 42

Ferrokinetic studies were carried out in 8 patients with heterozygous beta-thalassaemia with anaemia of varying severity. Effective and ineffective erythropoiesis, mean red cell lifespan and non-erythroid iron turnover were estimated from the experimental data through a mathematical model of iron kinetics. Erythropoietic activity was markedly increased in all patients, but was variably ineffective (from 10 to 74%). A negative correlation (r = 0.855, P less than 0.01) was found between the amount of ineffective erythropoiesis and Hb level. Red cell lifespan was variably shortened and there was a negative correlation between the degree of daily peripheral haemolysis and Hb level (r = 0.733, P less than 0.05). Non-erythroid iron turnover was increased in most patients. The results provide quantitative measurements of the mechanisms responsible for the wide variation of the Hb level in heterozygous beta-thalaeeaemia. Ineffective erythropoiesis seems to be the major reason for the anaemia. Peripheral haemolysis contributes to it, especially in the most severely affected patients. The increased non-erythroid iron turnover may be responsible for the pathology which characterizes heterozygotes in the adult life.
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PMID:Quantitative evaluation of the mechanisms of the anaemia in heterozygous beta-thalassaemia. 49 74

Iron status and erythropoietin (Ep) level in serum and urine were determined in 30 patients with anaemia in rheumatoid arthritis. The anaemia in these patients was mild and fulfilled the criteria for anaemia of chronic disorders. The iron status of these patients differed from the iron status in patients with sideropenic anaemia. Serum Ep, level, measured indirectly by the polycythaemic mouse bioassay, was either not detected or when detected it did not correspond to the degree of anaemia. The data suggest that the failure to produce sufficient amount of Ep, among other causes, could be important in the pathogenesis of anaemia in rheumatoid arthritis.
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PMID:Erythropoietin in patients with anaemia in rheumatoid arthritis. 49 76

The folacin and iron status and hemotological parameters of 193 persons 60 years of age and older from urban low-income households were evaluated. Of the serum folacin values 30% were between 3 and 6 ng/ml and 8% were below 3 ng/ml. Of these subjects 60% could be classified as "high risk" (less than 140 ng/ml) and 11% as "medium risk" (140 to 160 ng/ml) based on red blood cell folacin concentrations. Serum iron was normal (greater than 50 micrograms/dl) for all subjects as was transferrin saturation (greater than 15%). Hematological indices showed a 14% incidence of anemia (hemaglobin less than 12 g/dl), and 32% incidence of leukopenia (leukocytes less than 4.8 X 10(3)). These findings demonstrate widespread folacin deficiency and no evidence of iron deficiency in these elderly people.
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PMID:Folacin and iron status and hematological findings in predominately black elderly persons from urban low-income households. 49 52

Iron-deficient rats have increased blood and urinary catecholamines regardless of whether anemia is or is not present. The catecholamine response in both iron-deficient and control animals is largely temperature dependent, showing little difference at the isothermic temperature of 30 degrees C but a two- to threefold increase in iron-deficient animals over controls at lower temperatures. The iron-deficient rat is unable to maintain body temperature at 4 degrees C and this is independent of anemia or of food intake. When animals are run on the treadmill for 4 h, body temperatures increase but the difference observed at 4 degrees C between iron-deficient and control animals persists. The underlying abnormality in temperature regulation and in catecholamine response disappeared after 6 days of iron therapy.
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PMID:Catecholamine elevation in iron deficiency. 49 78


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