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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Heterozygous classical beta-thalassemia was found in 13 subjects of pure German descent, 11 of them from the Bergische Land (NW Germany) during the past three years. Clinically it became manifest in a moderate degree of anemia with marked hypochromia and reduced mean corpuscular volume. The number of red blood corpuscles and the value for serum iron were ascertained to be in the upper limits of normal or raised. The diagnosis of Mediterranean anemia was confirmed by hemoglobin electrophoresis with a rise in HbA2 of more than 3%. A slight increase in HbF may also occur. The importance of genetic counseling of thalassemia patients is emphasized. The occurrence of thalassemia even in pure German populations must be increasingly reckoned with.
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PMID:[Thalassemia minor in families of German descent in the Bergische Land (author's transl)]. 40 46

Protein-energy malnutrition in Kivu is associated with a discrete normocytic, normochromic anemia. An attempt to define the physiopathology of this anemia disclosed the following results. As compared with local controls, both iron and total iron binding capacity were low, but with siderophilin saturation and sideroblast counts either normal or elevated; serum and erythrocyte folate was normal, plasma vitamin B12 was normal or elevated, and serum ascorbic acid was normal or elevated. The riboflavin nutritional status was normal. During refeeding, iron and riboflavin deficiencies became apparent. Characteristic findings on admission were the presence of giant erythroblasts and a diminished erythrocyte survival time implicated to an intracorpuscular hemolysis. Two results from the present study could contribute to explanation for the aforementioned abnormalities: low plasma vitamin E levels and, perhaps more importantly, low plasma selenium levels. In conclusion, the anemia of protein-energy malnutrition, as observed in Kivu, is a classifiable nonadaptive anemia that cannot be explained by isolated iron or vitamin deficiencies and whose physiopathology is distinct from that of the anemia of chronic disorders. It is suggested that a selenium deficiency may play an important role in the pathogenesis of this anemia.
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PMID:Protein-energy malnutrition and anemia in Kivu. 41 29

The prevalence of protein energy malnutrition (PEM) and nutritional anaemia was investigated in 392 black children, aged 13--60 months, living in a poor rural area. Breast feeding was practised extensively in the population (median duration 14 months). The overall prevalence of PEM was 16,4%, but severe PEM occurred in only 2,7% of the children. Anaemia was present in 6,7% of children, and was almost invariably associated with iron deficiency. Biochemical evidence of iron, folate and vitamin B12 deficiency was detected in 36%, 14,8%, and 0,3% of children respectively. Anaemia was almost confined to the 1-year-old group, but biochemical evidence of iron deficiency, while highest in this age group, continued into the 2-4-year age group. No relationship was found between ecological factors such as income, educational status, etc. and any of the anthropometric, biochemical or haematological variables. The prevalence of PEM and anaemia in these poor rural children is lower than that of a comparable group of underprivileged urban children, thus emphasizing that city slum conditions are producing considerable nutritional problems in their wake. It is of importance to investigate further why some children who are severely deprived in many ways do not necessarily manifest a proportional degree of nutritional deprivation.
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PMID:Protein energy malnutrition and nutritional anaemia in preschool children in rural KwaZulu. 41 6

The special supplemental food program for women, infants, and children administered by the United States Department of Agriculture, was evaluated nationally. Participating infants, children under 4 years old, and pregnant and nursing women were investigated initially, and after receiving food supplements. The supplements were iron-fortified infant formula, iron-fortified infant cereals, and fruit juices for the infants, and milk, cheese, iron-fortified cereals, eggs, and fruit juices for the children and women. Initially, the average birth weight was lower and the infant mortality rate was higher than expected in a well nourished population. There was also evidence of slight growth retardation, a high anemia rate, and a high percentage of participants having saturation of transferrin values less 15%. The program had no effect on the prevalence of unsatisfactory values for saturation of transferrin. There was an increase in weight gain during pregnancy, and increase in birth weight, an acceleration of growth, and a reduction in the anemia rate in all participant categories except women in the first and second trimesters of pregnancy.
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PMID:Medical evaluation of the special supplemental food program for women, infants, and children. 42 Jan 56

The circulatory levels of hemoglobin and the frequency of anemia were determined in a representative sample of children with a mean age of 6.7 years. A random sample of 500 children of the city of Durango was studied. Durango has an altitude of 1893 m above sea level. The mean value of hemoglobin was 12.57 g/100 ml, with a range of 9.4 to 15.0 and a SE of 0.05. There was no difference statistically significant between the sexes. Considering 12.0 as the lower normal limit for hemoglobin values, it was found that 16% of the children were anemic, 49% of the anemic children were iron deficient, with iron serum levels of less than 60 ug/100 ml. The relationship between anemia and number of living children, birth order and weight was established. The frequency of anemia was higher among children coming from families with 4 or more living children.
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PMID:[Prevalence of anemia in a sample of school children in Durango City]. 42 31

The study included 30 children with anemia and significant infectious process. The hematologic characteristics of this anemia were identified in their evolution and these findings were correlated with levels of serum iron to disclose whether variations are present to support the diagnosis of mixed etiology of the anemic syndrome. Transferrin saturation index was found to be the best parameter to diagnose iron deficiency in cases of anemia associated to infectious processes and due to the fact that 50% of these cases showed mixed etiology anemia, it seems reasonable that further integral studies should be carried out in this anemic syndrome.
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PMID:[Hematologic characteristics of anemia associated with infectious processes]. 42 30

1. An epidemiological study of iron status in general practice has been undertaken. An age-sex register was established and a 10% stratified random sample (194 males and 220 females) of the patients above the age of 15 years was studied. A full blood count, serum Fe concentration, transferrin saturation and serum ferritin concentration were measured and correlated with clinical features associated with Fe deficiency. 2. The geometric mean for serum ferritin for males was 77 micrograms/l (20-196 micrograms/l) and for females 37 micrograms/l (8--177 micrograms/l). A low serum ferritin (male less than 30 micrograms/l, female less than 20 micrograms/l) in the absence of anaemia was found in fifteen males and thirty-five females. In this group forty patients had clinical features which are aetiologically associated with Fe deficiency. The incidence of similar features in a control group of thirty-three patients was seven. 3. It is suggested that this is indirect evidence that serum ferritin concentration is the most sensitive monitor of Fe status enabling the detection of pre-anaemic Fe deficiency.
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PMID:Iron status in a general practice and its relationship to morbidity. 42 82

Large X-ray fields, such as those used to irradiate major lymph-node areas in the treatment of lymphomas, often irradiate large areas of haemopoietic bone marrow. The absorbed doses received by the marrow are close to the tolerance level. Quantitative scanning of the bone marrow, using 52Fe and a digital whole-body scanner, has been carried out in a series of 22 patients treated by radiotherapy up to nine years previously in order to assess the extent and recovery of their erythropoietic marrow. The results showed large variations from patient to patient; in some patients the iron uptake in the marrow returned to near normal levels in two to three years, while in others the uptake remained suppressed after seven to eight years. The tolerance dose for the bone marrow appeared to be about 1100 ret. There was some evidence of a more rapid recovery of erythropoietic function in males than females, but no evidence to show that age of patient, type of disease or whether chemotherapy had been used influenced the results. Patients who showed a decreased iron uptake in an irradiated region of marrow generally showed a compensating increased uptake in unirradiated regions, which in some cases was associated with anaemia.
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PMID:The recovery of iron uptake in erythropoietic bone marrow following large field radiotherapy. 42 54

Serial microscopic immunodiffusion assays of F cells, i.e., erythrocytes that contain fetal hemoglobin (HbF), in four individuals recovering from anemia demonstrate initial increases in the percentage of circulating reticulocytes that contain HbF (F reticulocytes) and subsequent increases in the percentage of mature erythrocytes that contain HbF (F erythrocytes). In one individual responding to therapy for iron-deficiency anemia, the average percentage of F reticulocytes increased from 4.8+/-1.1 to 16.0+/-2.8% (mean+/-SD), while the mean level of F erythrocytes increased from 3.5+/-0.7 to 7.2+/-0.6%. Two normal children with transient erythroblastopenia exhibited F reticulocyte percentages of 71.3+/-6.7 and 41.5+/-1.5%, respectively, when erythropoiesis resumed. With recovery these values fell to finally measured values of 33.7+/-4.7 and 12.6+/-1.1%, respectively. In an adolescent with sickle cell anemia, F-reticulocyte percentages fluctuated between 0.6+/-1.1 and 34.0+/-2.8% and paralleled the rise and fall of total reticulocytes associated with therapy for a nasopharyngeal carcinoma. Such findings suggest that first, the production of F cells and non-F cells are separately regulated. Second, F-cell production is preferentially stimulated during escape from erythropoietic suppression and selectively depressed at the start of suppression. Third, during escape from erythropoietic suppression, F-cell production in vivo resembles that reported for in vitro cultures of erythroid stem cells. Fourth, individuals with sickle cell anemia, like individuals without hemoglobinopathies, can change their relative level of F-cell production.
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PMID:Production of erythrocytes that contain fetal hemoglobin in anemia. Transient in vivo changes. 42 49

Angiodysplasias of the colon are rare causes of intestinal bleeding. Diagnosis is by angiography or colonoscopy. In 6 patients with severe anemia in whom conventional methods had failed to reveal the source of bleeding, colonoscopy demonstrated angiodysplasias in the cecum or ascending colon. They were treated endoscopically. In a follow-up period of 3 months to 4 years only 1 patient has sometimes suffered occult fecal blood loss, but is adequately treated by oral iron therapy. No patient has had a severe recurrence of bleeding, nor was colonic resection necessary. It is concluded that endoscopic therapy of angiodysplasias is a valuable alternative to surgery with low risk and high efficiency.
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PMID:[Angiodysplasia of the colon: diagnosis and therapy]. 43 90


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