Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diclofenac sodium is a widely used enteric-coated nonsteroidal anti-inflammatory drug. We describe a woman with Hemoccult-positive stools and iron deficiency anemia who developed both a colonic ulcer and a "diaphragm-like" colonic stricture while taking enteric-coated diclofenac. These lesions were evident on colonoscopy but not on barium studies. Biopsy specimens of the ulcer and stricture revealed particulate matter that was indistinguishable from diclofenac pill fragments by electron microscopy. Discontinuation of diclofenac therapy resulted in resolution of anemia and Hemoccult-positive stools. We conclude that (1) enteric-coated diclofenac is associated with both colonic ulcers and diaphragm-like colonic strictures; (2) the pathophysiologic mechanism for the development of both ulcers and strictures may involve a direct action of diclofenac within these lesions; (3) colonoscopy may be superior to barium studies in evaluating patients receiving diclofenac who have iron deficiency anemia and/or Hemoccult-positive stools.
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PMID:'Diaphragmlike' stricture and ulcer of the colon during diclofenac treatment. 144 95

Three groups of rats were infected with Trypanosoma brucei. Two of the groups were treated with either asteroidal (Cortisol) or a non-steroidal (Voltaren) anti-inflammatory drug to compare the effects of the two drugs on the disease process. The anaemia was least severe in the Cortisol treated group which suggests that its supportive use in the treatment of natural infections with the brucei subgroup of trypanosomes may be advantageous.
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PMID:The comparative effects of cortisol and voltaren on anaemia and temperature changes in experimental Trypanosoma brucei infection in rats. 372 72

We present a 55 years old male with severe anemia with history of pain abdomen for 2 weeks and malena of 10 days duration. He was taking NSAID (Diclofenac sodium). Upper GI endoscopy done twice did not reveal any abnormality. Upper gastrointestinal (UGI) barium series with small bowel follow through revealed a diverticulum on medial wall of second part of duodenum and there was evidence of ulcer in diverticulum. He underwent diverticulectomy. On follow up after 6 months patient was asymptomatic.
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PMID:Duodenal diverticular haemorrhage in a patient taking NSAID. 1272 64