Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The disturbed balance of globin chain synthesis is a major factor in the pathophysiology of the thalassaemic disorders; this concept is strongly supported by the study of a patient displaying an extreme but symmetrical deficit of both major types of chains alpha and beta. The patient had a mild clinical picture but presented a striking hypochromia (MCH 10 pg) with compensatory erythrocytosis (RBC 10(12)/l.). Study of the propositus and his family by haematological, biochemical and biosynthetic techniques indicates that the patient carries two alpha- and two beta-thalassaemia genes resulting in balanced globin chain synthesis; in addition, several members of the family carry two or three abnormal genes. During observation a change in the haematological pattern occurred with a shift towards more intensive beta-chain and away from gamma-chaim synthesis; this appeared with be associated with improvement of his anaemia through more effective erythropoiesis.
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PMID:A unique thalassaemic syndrome: homozygous alpha-thalassaemia + homozygous beta-thalassaemia. 69 15

The repair processes with posthemorrhage anemia were studied in experiment and clinics as affected by the preparation (sodium bicarbonate and magnesium, manganese and zinc sulphates in a ratio of 25:5:0.1:0.1) which stimulates the carboxylation reactions in the organism. Stimulation of the carboxylation reactions in the rabbits with experimental posthemorrhage anemia increases the intensity of 14CO2 carbon transformation of organic compounds in the tricarboxylic cycle, intensifies 14C incorporation into the liver, kidneys, spleen and marrow proteins as well as into serum albumin and globulins. Under clinical conditions stimulation of CO2 fixation with the preparation favours an intensified formation of the red series cells and biosynthesis of hemoglobin and serum proteins as well as the repair of their disturbed balance in patients with posthemorrhage anemia. The content of magnesium in blood plasma normalizes.
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PMID:[Effect of carboxylation reactions stimulation on intensity of 14CO2 fixation in rabbits with posthemorrhage anemia and on repairing of blood components in human anemia]. 89 21

Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts and osteoclasts. Bone morphogenetic proteins (BMPs) are present in the bone marrow and are important for several aspects of myeloma pathogenesis including growth and survival of tumor cells, bone homeostasis, and anemia. Among cancer cells, myeloma cells are particularly sensitive to growth inhibition and apoptosis induced by BMPs and therefore represent good models to study BMP receptor usage and signaling. Our review highlights and discusses the current knowledge on BMP signaling in myeloma.
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PMID:The role of bone morphogenetic proteins in myeloma cell survival. 2485 40