Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients had diffuse, reversible pulmonary injury possibly owing to gold sodium thiomalate treatment: a 32-year-old woman with chronic inflammatory arthritis compatible with seronegative rheumatoid arthritis and a 32-year-old man with shoulder arthralgia. The patients had received 420 mg and 325 mg of gold sodium thiomalate, respectively. Cough and dyspnea began in the seventh and fifth weeks of therapy, respectively. In both patients x-ray study showed bilateral pulmonary infiltrates, with no evidence of pleural disease. The woman had no other manifestations of hypersensitivity to gold. The man had exfoliative dermatitis fever and anemia. Lung biopsies from both patients revealed lymphocytes and plasma cells infiltrating the alveolar septa and interstitial fibrosis. The woman improved slowly during four months after discontinuation of therapy. Pulmonary symptoms recurred after additional gold therapy, and again resolved when gold was discontinued. The man, treated with prednisone, showed prompt remission and remains will without medication.
 ...
PMID:Diffuse pulmonary injury associated with gold treatment. 13 May 54

Seven young men developed acute pulmonary hemorrhage and edema from the inhalation of powder or fumes of a bisphenol epoxy resin containing tri-mellitic anhydride (TMA) while working in a steel pipe-coating plant. The illness was characterized by cough, hemoptysis, dyspnea, fever, weakness and nausea or vomiting. Chest roentgenograms showed either a bilateral or unilateral pulmonary infiltrate. All patients had a normochromic type of anemia. Pulmonary function studies demonstrated a restrictive defect, hypoxemia, and increased A-a DO2 gradients. Light and electron microscopic studies of lung tissue revealed extensive bleeding into alveoli but no basement membrane deposits were seen and no antiglomerular basement membrane antibodies were detected. The patients improved quickly without treatment. Follow-up studies of six patients three weeks to one year after their illness revealed apparent recovery. A detailed medical survey carried out on all 29 workers currently employed in the plant revealed five additional men had experienced severe recurrent pulmonary problems.
 ...
PMID:Pulmonary hemorrhage and edema due to inhalation of resins containing tri-mellitic anhydride. 49 27

The clinical aspects of Hemoglobinopathy S in children of a black family from Zair living in Belgrade are discussed in the paper. The parents and two brothers are heterozygous carriers for patologyc hemoglobines; those children had, sauf permanent anaemia, the crysis of dyspnea, cyanosis, cough, evidence of subperiosteal bone formation, associated with vitamin D deficiency. The Youngest child, girl two years of age, is homozygous with complete Sickle cell disease: hand-foot syndrome, heterotopic paravertebral hematopoetic tissue, lung infarctions, cardiomegaly, severe drepanocytic anaemia; she succumbed in an a attack after many episodes of severe hypoxia.
 ...
PMID:[Hemoglobinpathy S--clinical manifestations in children in a Zairian family]. 61 14

A six-months-old heifer died within two days of showing signs of anaemia and dyspnoea. The death was attributed to autoimmune haemolytic anaemia (AHA) because of auto-agglutination which increased on Coomb's testing and the presence of antibovine IgG on the erythrocyte surfaces.
 ...
PMID:Bovine auto-immune haemolytic anaemia. 69 64

A 28-year-old man developed recurrent hemoptyses, breathlessness, anemia, and bilateral pulmonary infiltrates after mild smoke inhalation. He had no laboratory evidence of kidney involvement. Transbronchial lung biopsy showed erythrocytes, iron-containing macrophages within alveolar spaces, normal basement membranes, and strongly positive linear staining of alveolar septa for immunoglobulin G (IgG). Serum antiglomerular basement-membrane antibody was strongly positive by radioimmunoassay. Kidney biopsy showed normal findings by light and electron microscopy but strongly positive linear staining of glomerular capillaries for IgG. Follow-up 9 months later while the patient was taking prednisone revealed no clinical evidence of pulmonary or renal disease. This case shows that immunopathologic study of transbronchial lung biopsies is helpful in differentiating between Goodpasture's syndrome and idiopathic pulmonary hemosiderosis, while the absence of clinical and microscopic evidence of kidney disease does not exclude Goodpasture's syndrome.
 ...
PMID:Goodpasture's syndrome: diagnosis by transbronchial lung biopsy. 71 32

Clinical and haematological findings at the nadir of the refractory, early anaemia of prematurity were compared in a study of 95 preterm infants. 53% of 30 babies less than 32 weeks' gestational age at birth had abnormal clinical features resulting from anaemia at its nadir, with a combination of tachycardia, tachypnoea, dyspnoea and feeding difficulties, diminished activity, and pallor. The expression 'available oxygen', derived from the Hb concentration and Hb-O2 affinity, correlated more closely with clinical features of anaemia that did the Hb concentration alone. A formula is presented that predicts the 'available oxygen', provided the Hb concentration and post-conceptual age are known; this avoids the need for direct measurement of Hb-O2 affinity. Clinical anaemia is common in preterm infants with Hb concentrations of up to 10.5 g/dl, consequent on the high O2 affinity of fetal Hb. This is the first description of any common clinical consequence of high Hb-O2 affinity.
 ...
PMID:Nonphysiological anaemia of prematurity. 72 8

By means of continous flow centrifuge the authors have obtained suspensions of granulocytes from the blood of healthy donors. Results of granulocytophereses are presented here with the main points in the therapy of granulocytopenic patients with granulocytes rich suspension. The mean volume of the obtained suspension was 418ml. and it contained 9,78 X 10(9) leukocytes. 70 percent of them were granulocytes, the said volume contained 48 ml of red blood cells. All the donors had been premedicated with i.v. dexamethason (4mg./kg body weight). No one of the 51 donors developed anaemia or hypoproteinemia. After the application of the protamin sulphate, however, two donors had face flushing breathlessness and gastric ache. These symptoms disappeared after the administration of corticosteroids. Although they are connected with the administration of protamin sulphate we can not explain them.
 ...
PMID:[Preparation of granulocyte concentrates from healthy donors using a continuous-flow centrifuge (CFC)]. 100 98

Evidence for severe intrapulmonary bleeding was obtained in 3 anticoagulated patients who presented with pulmonary infiltrates. The diagnosis of pulmonary hemorrhage was based on findings of markedly elevated quantities of stainable hemosiderin and hemoglobin in alveolar macrophages retrieved by bronchopulmonary lavage. In 2 of the patients, roentgenographic abnormalities regressed after anticoagulation was reversed. The third patient died and massive bilateral pulmonary hemorrhage was found at autopsy. The syndrome of occult pulmonary hemorrhage was characterized clinically by dyspnea, unexplained acute anemia, and infiltrates with an alveolar pattern on chest roentgenogram. Hemoptysis was conspicuously absent. Bronchopulmonary lavage and quantification of alveolar macrophage hemosiderin content may be useful in identifying intrapulmonary bleeding occurring in an otherwise occult manner. Recognition of pulmonary hemorrage in anticoagulated patients is important because reversal of anticoagulation can be life saving.
 ...
PMID:Occult pulmonary hemorrhage in anticoagulated patients. 114 81

Adequate oxygen delivery to the tissues can usually be assured until the hemoglobin concentration falls below 7-8 g/dl in patients with chronic anemia provided their compensatory mechanisms are not impaired. Such a reduction of hemoglobin concentration is usually tolerated without symptoms at rest. Under increased physical activity or by an underlying impaired function of the lung or the cardiovascular system, adaptation to anemia may not be sufficient. For this reason the impact of anemia and the resulting hypoxemia must be assessed by determining oxygen needs at various levels of physical activity. The clinical assessment for adequate oxygenation of tissues can be sufficiently estimated by simple parameters as tachycardia, dyspnea etc. Benefits from replenishing O2 carrying capacity by transfusion must be always balanced against transfusion-associated risks. Below a hemoglobin concentration of 7 g/dl oxygen transport is impeded and transfusions are necessary to avoid jeopardizing the patient by additional stressful illnesses such as fever.
 ...
PMID:[The critical hemoglobin value in the therapy of chronic anemia]. 128 10

In the first part of this article the clinical and paraclinical criteria of intra-alveolar haemorrhages are reviewed. The principal signs and symptoms are dyspnoea, haemoptysis, anaemia and bilateral alveolar and interstitial opacities. Computerized tomography of the chest shows a non-systematized alveolar filling. In the second part, the cytological and histological criteria are considered; they are provided by examination of the alveolar lavage fluid and by lung biopsy. Finally, the main elements in the physiopathology and causes of these haemorrhages are successively described.
 ...
PMID:[Diagnostic criteria, physiopathology and etiology of intra-alveolar hemorrhage]. 129 59


1 2 3 4 5 6 7 8 9 10 Next >>