Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-eight Friesian calves were infected between seven and 11 months of age with 5000 to 45,000 cercariae of Schistosoma mattheei. They developed anaemia, lymphopaenia and hypoalbuminaemia during the period of acute clinical illness after the infection became patent, and lymphocyte counts remained depressed after clinical recovery. Neutrophil counts rose and later fell before returning to normal. Eosinophilia and hypergammaglobulinaemia were marked during the period of recovery. The changes in haemoglobin, neutrophils and serum proteins were proportional to the level of infection. The eosinophil response was reduced in animals subjected to nutritional stress. The aetiology of the changes is discussed.
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PMID:Schistosoma mattheei in the ox: clinical pathological observations. 60 95

A survey of workers and families resident in an oil palm estate in Malaysia revealed high incidence of parasitic infections. The commonest parasites are T. trichiura (56%), A. lumbricoides (52%), hookworm (28%), Entamoeba coli (11.3%) and Giardia lamblia (11.3%). Mixed infections by two or more parasites was seen in 46% of the subjects. Anaemia was present in 70% of children with hookworm infection. Eosinophilia was observed in 69% of subjects. One each of Hymenolepis nana and Hymenolepis diminuta infection was detected. This is the first report of Hymenolepis diminuta infection in man in Malaysia.
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PMID:Prevalence of parasitic infections in Malaysian oil palm estate workers. 72 60

Biological and histological studies were performed in 42 cases of gastro-intestinal intolerance to cow's milk proteins. Hypoproteinemia was present in 2/3 of the cases, anemia in 3/4. Malabsorption syndrome (steatorrhea, xylose) was overt in less than 1 patient out of 2. Serum level of vitamin A was more frequently depressed than that of vitamin E and folinic acid. Intestinal biopsy, performed in 32 children, showed consistent abnormalities, a partial atrophy of the villi being most often seen (26 cases). Eosinophilia was present in 50% of the cases. A titer of anti-milk agglutinins of 1/64 or above was always found if the test was performed repeatedly when the diet of the children contained milk. Lymphocyte proliferation in culture, induced by milk proteins, was positive in 70% of the cases. None the less, no biological or histological findings were found to be specific for gastro-intestinal intolerance to milk proteins.
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PMID:[Digestive intolerance to cow's milk proteins in infants. Biological and histological study]. 124 Jul 51

Anemia is frequently found in patients with rheumatoid arthritis (RA) and is the most common extra-articular manifestation RA. The majority of patients with RA have a mild normocytic hypochromic anemia which correlates with the erythrocyte sedimentation rate and with activity of the disease. White blood cell counts are usually in the normal range or only slightly elevated. The differential white blood cell count is usually within normal limits. Eosinophilia and thrombocytosis are often associated with RA. Hematologic abnormalities of RA is correlated to the activity of the disease, and therefore the most important aspect of treatment lies in the general control of the chronic inflammation.
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PMID:[Hematologic abnormalities associated with rheumatoid arthritis]. 158 52

Ten characteristics of bone marrow (BM) biopsies in paraffin sections, obtained at diagnosis from patients with myelodysplastic syndromes (MDS) classified according to the FAB criteria, were analysed to identify both the most relevant morphologic data and any possible influence on survival. Agreement between two observers was obtained for 94% of the data. BM cellularity was increased in 63% of the cases and was higher in refractory anaemia with excess of blasts (RAEB). RAEB in transformation (RAEB-t) and chronic myelomonocytic leukaemia (CMML) (P = 0.001). Dysmegakaryopoiesis and dyserythropoiesis were present respectively in 83% and 72% of the cases, with slight differences among the FAB subtypes. Abnormal localization of immature precursors (ALIP) was found in more than half of the cases and somewhat more frequently seen in the RAEB + RAEB-t + CMML group (P = 0.07). Eosinophilia, plasmacytosis and reticulin fibrosis were evident in 26%, 18% and 47% of the cases respectively. Cellularity (P = 0.006), eosinophilia (P = 0.009) and, to some extent, dysmegakaryopoiesis (P = 0.07) bore a certain relationship with survival on univariate analysis. The presence of ALIP was not seen to affect the outcome. Multivariate analysis showed that the cellularity and presence of dysmegakaryopoiesis, in BM biopsy, added significant independent prognostic information to that achieved with age, platelet count and proportion of blast cells in BM aspirate, three variables with proven prognostic value in MDS patients. Using a regression model including these five characteristics we have stratified the patients into low, intermediate and high-risk groups with different survivals (P = 0.00001). The present findings show that BM biopsy is able to provide both morphological characteristics and information about the prognosis of survival, and should thus be included in the initial evaluation of MDS.
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PMID:Bone marrow biopsy in myelodysplastic syndromes: morphological characteristics and contribution to the study of prognostic factors. 237 20

A retrospective study was done to evaluate bone marrow smears in seven children with systemic onset juvenile rheumatoid arthritis (JRA). Eosinophilia and monocytosis were found in all the patients and in five there also were increased proportions of mononuclear basophils. Anemia is common in this disease and erythroid hypoplasia was present in six cases. Four patients had increased numbers of plasma cells and three had histiocytes with hemophagocytic activity. We did not find hemophagocytosis, as reported before, in bone marrow smears of JRA patients.
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PMID:[Myelogram in systemic juvenile rheumatoid arthritis]. 252 Aug 40

Endemic Balkan nephropathy (EBN) is a chronic interstitial nephritis which may occur at any age and may affect several members of the same family. The condition is slowly progressive and can more easily be diagnosed in its advanced than in its early stages. Early symptoms include severe anaemia and increased plasma aminoacids, alkaline phosphatases and gamma 2 and alpha globulins. Eosinophilia is not uncommon. Loss of urine concentration power and high beta 2 microglobin urinary levels are among the earliest signs of EBN and of considerable diagnostic value. Renal biopsy shows invasive sclerosis, IgG and IgA deposits in glomerular vessels and Bowman's capsule walls and, characteristically, osmiophilic granulations within the mitochondria of proximal tubule cells; the mitochondria may in due course burst and disappear. Atrophic or dystrophic changes may develop in the stomach, upper intestine and liver. The aetiology of EBN remains undetermined, but chronic intoxication with drinking water polluted by silicates released during soil erosion seems to be the most probable cause. Silicates may act directly or by inducing an immune process.
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PMID:[Endemic Balkan nephropathy (author's transl)]. 625 17

Case records of 26 patients with Lyell Syndrome were reviewed for studying haematologic abnormalities. Eosinophilia, neutropenia, thrombopenia were uncommon. Circulating immature granulocytic cells were frequently encountered during the second week of evolution, mostly when leucocytosis was present. Anemia was frequent, the lowest haemoglobin titer beeing reached by the 15th day. Reticulocytosis was initially low and reached a peak during the second week. At that time biological markers of inflammatory syndrome were getting worse. So the originating anemia seems primarily of medullary origin and independent of inflammatory syndrome. Lymphopenia was constant and sometimes marked, with no circulating lymphocytes in two cases. The lowest numbers of lymphocytes were observed during the first week. These haematological abnormalities may have some pathogenic significance.
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PMID:[Hematologic anomalies in Lyell's syndrome. Study of 26 cases]. 688 53

The pathogenesis of early prepatent Fascioloides magna infection was investigated in seven fawns (Odocoileus virginianus) given 500 metacercariae and examined at one, two, three, five, eight, 12 and 13 weeks postinoculation. Blood samples were taken from eight inoculated deer every two weeks up to 16 weeks postinoculation. Eosinophilia with a mild transitory anemia were the main clincopathological features. Postmortem examination at two weeks postinoculation revealed extensive migration of immature flukes. Subcapsular tracks in the liver, nodules on the blind sacs of the rumen, as well as retroperitoneal granulomas on flanks and necrotic tracks on the diaphragm were found. Evidence of penetration of flukes into the lung was found at two weeks postinoculation and there was early granuloma formation at three weeks postinoculation. Flukes migrating into tissues other than the liver were destroyed in large granulomas, although remnants of degenerating parasites were not found. At eight weeks postinoculation, widespread granuloma formation characterized the infection with this lesion present in nodes along the gastrointestinal tract, in the mesentery, flanks, psoas muscles, diaphragm, between the ribs and in the lungs. By 12 weeks postinoculation subcapsular tracks were observed in the liver.
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PMID:Pathogenicity of immature Fascioloides magna in white-tailed deer. 744 29

Eosinophilia has long been known as a hallmark of Churg-Strauss syndrome but has rarely been reported in Wegener's granulomatosis (WG). Here we describe a patient with WG who had skin, kidney and lung involvement as well as striking peripheral eosinophilia and hyperimmunoglobulinaemia E (hyper-IgE). The patient's clinical picture was complicated by intra-alveolar haemorrhage resulting in severe anaemia and respiratory failure. The pulmonary symptoms recovered completely, but the renal involvement evolved into end-stage renal failure despite intensive immunosuppressive treatment, intravenous immunoglobulin and plasmapheresis. We suggest that the presence of eosinophilia and hyper-IgE might contribute to the development of different disease patterns in WG.
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PMID:Eosinophilia and hyperimmunoglobulinemia E as the presenting manifestations of Wegener's granulomatosis. 1457 94


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