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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The new generation of oral contraceptives (OCs) contains less than 50 mcg of estrogen compared to previous levels of 100-150 mcg, and as a result have fewer undesirable side effects. In addition, it appears that the newer OCs decrease the susceptibility to many diseases. For example, the pill decreases by 40% the risk that a woman under 55 years of age will develop ovarian cancer. The risk of endometrial cancer is reduced by 50% in OC users. The pill also significantly lowers the risk of pelvic inflammatory disease--a condition that is involved in almost 20% of all gynecologic problems and is a leading cause of infertility. OC use reduces the risk of ectopic pregnancy. Further, by decreasing menstrual blood flow, the pill protects against iron-deficiency anemia. The pill is claimed to decrease premenstrual tension, menstrual cramps, and even acne. It has a protective effect against ovarian cysts and benign breast cancer. Finally, there is the possibility that OCs protect against the development of rheumatoid arthritis and duodenal ulcers.
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PMID:Oral contraceptives come of age. 385 23

The haematological and obstetric details of five women with Addisonian pernicious anaemia and infertility are described together with those of another patient who developed the anaemia soon after confinement. The implications are discussed, and it is concluded that the prophylactic administration of small doses of folic acid during pregnancy is a safe procedure while the risk of precipitating subacute combined degeneration of the cord in undiagnosed Addisonian pernicious anaemia is hypothetical. Although the mechanism of the infertility in pernicious anaemia remains undefined, several factors which may be of aetiological significance are considered.
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PMID:Prophylactic folic acid in women with pernicious anaemia pregnant after periods of infertility. 569 63

Mast cells derived from haematopoietic tissue are deficient in numbers in spleen, stomach and skin of Harwell mice doubly mutant at the spotting W locus: seven viable combinations of four mutants. Most combinations have variably impaired viability, anaemia and infertility; but homozygous WshWsh are normal in these respects yet still lack mast cells. The effect of the W gene on mast cells acts in recessive fashion. Effects of doubly mutant W genes on mast cells and coat colour, the latter usually regarded as dominant, appear more closely related than other pleiotropic effects. The spotting gene Ph, closely linked to W, has but marginal effects on mast cells, whereas mi, another spotting gene, quite unrelated to W affects mast cells in the spleen in a dominant way. Thus, splenic mast cells may be a special category of a heterogeneous population. Peptic ulceration, recorded in W/Wv mice of Jackson stock, was not seen in Harwell mice. We suggest that this lesion is due to genetic complementation or environmental causes.
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PMID:Mast cells in spotted mutant mice (W Ph mi). 612 14

This report describes the current status of maternal and child health care (MCH) in Mozambique and was prepared by an American nurse-midwife, hired by the Mozambique government as an instructor for the country's nurse-midwife training program. The socialistic government, under its international cooperates program, hires advisors and instructors to help implement the nation's many health, education, and economic development programs. In 1975, when the country was granted independence, the health care system was grossly inadequate. During the colonial period, the health system was oriented toward providing care for the white, urban population rather than for the country's largely rural population. Prefessional jobs were reserved for Portuguese nationals, and Africans were not allowed to attend the nationhs medical schools. When independence was obtained, all but 50 of the nation's 600 physicians left the country. The development of MCH services is given a high priority by the current government. It is estimated that currently 35% of the all children born in the country die before they reach the age of 5 years. The maternal mortality rate is estimated to be 300/100,000. Efforts to improve health conditions are hindered by a lack of trained personnel, money, and medical equipment and supplies and by an inadequate transportation network. Despite these obstacles, progress in the provision of MCH services is being made. MCH units are being established throughout the country. These units are generally operated by trained nurse-midwives. A national nurse-midwife training program is conducted at the National Health Science Institutes in Quelimane. Trainees must be at least 18 years of age and have 6 or more years or primary schooling. The 2 1/2-year training program is intensive and students receive practical experience by working at an adjacent provincial hospital. Upon graduation, most assume the responsibility for operating a rural MCH unit. They are expected to provide services for a large population and to do so with little or no medical backup and minimal equipment and supplies. As part of their training, they learn how to prioritize health care and how to recruit community volunteers to help run the unit. The rural MCH units provide prenatal services, including high risk pregnancy referrals, nutritional counseling, and treatment for parasites and anemia. Many of the nurse-midwives operate well child clinics. These clinics provide immunization and chloroquinization services and treatments for parasites and anemia for children under the age of 5 years. Nutritional counseling is provided for the mothers of the children. Growth charts are used to identify malnourished children in need of hospital care. The midwives encourage breastfeeding. Recently a family planning component was added to the MCH program. Oral contraceptive, IUDs, foam, and condoms are provided. The program stresses the use of contraception for spacing rather than for limiting child births. Infertility is common among the rural women, and some midwives provide limited infertility counseling and evaluation. 30% of the country's deliveries are now performed in maternity units. These units range from hospital facilities to small, minimally equipped rural units. In most rural units, the deliveries are performed by nurse-midwives without medical assistance. Given the poor health status of rural women, pregnancy complications are common, and the units are too inadequately equipped and staffed to cope effectively with these complications. As a result, maternal morbidity and mortality is high. The majority of the country's deliveries are still performed at home by untrained traditional birth attendants. No effort is being made to train the traditional birth attendants or to bring them into the national health care system.
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PMID:Nurse-midwifery in a developing country: maternal and child health in Mozambique. 656 73

The complications and outcome of 125 pregnancies in women with sickle cell disease between 1975 and 1981 are reviewed. There were no maternal deaths, but a perinatal mortality rate of 48 per 1000. The main maternal complications were sickling crises (38%), anaemia (65%), infections (61%) and severe pregnancy-induced hypertensive disease (5%). There were three patients with eclampsia. There was a 13% spontaneous preterm delivery rate, 25% of the babies were 'light-for-dates', fetal distress in labour was seen in 24% and 15% were delivered by caesarean section. There was an increased incidence of involuntary infertility and spontaneous abortion. The treatment by prophylactic blood transfusions is discussed.
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PMID:Pregnancy in sickle cell disease in the UK. 682 10

A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone.
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PMID:Inherited primary hypothyroidism in mice. 720 19

Health planners and policymakers in India had virtually no information about reproductive morbidity and its determinants on which to base efforts to improve the reproductive health of women and the acceptance of family planning programs. Thus, a study of self-reported symptoms of reproductive morbidity was undertaken in 1993 in the state of Karnataka as part of a larger research project investigating the pathways through which maternal education affects child survival. Data were gathered through a cross-sectional survey of women living in one subdistrict who were younger than 35 and had at least one child younger than five. Eligibility was limited to 3600 women living in the town and 48 villages with a population over 500. Experienced female interviewers achieved a more than 95% response rate. Disorders associated with the reported symptoms included: menstrual disorders, dyspareunia, hemorrhoids, prolapse, fistula, lower reproductive tract infection (RTI), urinary tract infection, acute pelvic inflammatory disease (PID), infertility, and anemia. Bivariate analysis revealed the significant variations in reports made by women of different socioeconomic, cultural, and demographic backgrounds; a parallel analysis was performed on the proportions seeking treatment for each condition; and logistic regression analysis estimated the net effect of each factor on the likelihood of reporting specific symptoms and the probability of seeking treatment. Independent variables were composed of socioeconomic background, demographic, last live birth and contraceptive usage, and cognitive and behavioral factors. A third of the women reported symptoms of at least one gynecological morbidity, and about half of these sought treatment. A tenth of menstruating women reported menstrual problems, a sixth reported symptoms of lower RTI, 5% reported symptoms indicative of acute PID, and 23% reported symptoms of anemia. Morbidity was influenced by the presence of complications during the pregnancy, delivery, or postpartum period of the last live birth; the location of the last delivery, with less problems reported by those who delivered in a private institution; and whether or not a woman had undergone tubectomy, which increased reporting of all symptom categories except menstrual problems. This points to the urgent need for longterm follow-up studies of sterilized women. Since most women sought private medical treatment, the primary health care facilities should be subject to a radical review and the private sector should undergo systematic evaluation.
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PMID:Self-reported symptoms of gynecological morbidity and their treatment in south India. 748 78

Homozygous beta-thalassaemia (thalassaemia major) is a severe, transfusion-dependent anaemia that also causes infertility due to endocrine impairment. Very few pregnancies are reported among such patients and there is only one report in the literature referring to a pregnancy achieved with ovulation induction and intra-uterine insemination. We report here the first successful twin pregnancy following in-vitro fertilization and tubal embryo transfer in a transfusion-dependent homozygous beta-thalassaemic woman with an oligoasthenozoospermic partner. Prior to ovarian stimulation, desferrioxamine was discontinued due to potential fetotoxicity. Pre-gestational transfusional and chelating therapies were resumed after delivery. In such patients, ovulation induction and assisted reproductive techniques appear crucial in achieving pregnancy with concurrent haematological balance without desferrioxamine administration.
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PMID:Transfusion-dependent homozygous beta-thalassaemia major: successful twin pregnancy following in-vitro fertilization and tubal embryo transfer. 784 35

A 16-month-old Charolais bull was examined because of acute onset of scrotal and hind limb edema, fever, tachycardia, tachypnea, anorexia, and lethargy. Scrotal circumference on initial examination was 48 cm. Clinicopathologic abnormalities included microcytic, normochromic anemia and numerous Eperythrozoon organisms in blood smears. Results of immunohistochemical staining of a skin biopsy specimen suggested that the edema was the result of an Arthus-type reaction. Semen quality deteriorated rapidly, and the bull was aspermic within 7 days. The bull was treated with oxytetracycline, and the anemia and edema gradually subsided. Eperythrozoon organisms were not detected in blood smears after 3 days. Six months after initial examination, results of physical examination and semen evaluation were normal. We hypothesize that scrotal edema caused failure of testicular thermoregulation, resulting in transient production of abnormal sperm and infertility.
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PMID:Infertility associated with Eperythrozoon wenyonii infection in a bull. 814 88

The literature relating to homozygous beta-thalassemia and the problems these patients have during their pregnancy is reviewed and another case report of a twin pregnancy in a homozygous beta-thalassemia individual is included. The majority of cases described refer to the intermedia clinical form of the hematological problem because patients with thalassemia major generally have poor sexual development. Although the reported cases had a greater frequency of delayed development, only one woman suffered from infertility and required ovulation induction agents. The thalassemia pregnant mother faces deleterious consequences resulting from chronic anemia and in nonsplenectomized patients there remains the risk of the onset of a hypersplenic crisis. The problems of splenectomized patients during pregnancy is also discussed. The chronic anemia of thalassemic patients predisposes to a poor fetal outcome with greater fetal loss, preterm labor, and intrauterine growth retardation.
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PMID:Beta-thalassemia syndromes and pregnancy. 816 11


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