Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report the case of a 54 year old male with diabetes insipidus and diabetes mellitus who developed, twenty years later, signs of hypogonadotropic hypogonadism, secondary adrenal insufficiency and primary hypothyroidism with positive serum antithyroglobulin antibodies. At that time, an osteolytic lesion on the left temporal bone was localized by radiologic studies. A bone biopsy confirmed the diagnosis of eosinophilic granuloma. Laboratory tests also showed anemia, hypergammaglobulinemia and accelerated eritrosedimentation rate which constitute atypical manifestations of this rare disease in adults. The probable etiopathogenic mechanisms are discussed: while some authors have described an autoimmune primary defect, others have suggested a primary viral infection as the cause of Hand-Schuller-Christian disease. The association of direct and indirect evidence of immunologic alterations in our patient is suggestive of an autoimmune origin.
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PMID:[Infrequent clinical manifestations in a patient with eosinophilic granuloma]. 248 46

Increasing numbers of patients take more drugs of ever-increasing potency. Dentists today see many of these patients. They should therefore be aware of the connection between drug administration and emergency situations. In certain instances drug-related complications, side-effects and emergencies of both a local and a general nature can arise. Some local complications are destruction of teeth due to the intake of medicines with high sugar content; erosive lesions of the oral mucosa; paraformaldehyde necrosis; and those arising from the use of chlorhexidine. Systemic complications are anaemia due to aspirin misuse; oral ulceration due to antirheumatic drugs; adrenal insufficiency after glucocorticosteroid medication; catecholamine reactions; anticoagulation therapy and bleeding problems; epilepsy; asthma; aplastic anaemia; opportunistic infections; and allergic reactions. The dentists should be prepared to diagnose and manage these complications whether they arise during dental treatment or following it.
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PMID:Complications in patients on therapeutic drugs. 294 78

Kasabach-Merritt syndrome presents various problems for anesthetic management, which include thrombocytopenia, bleeding tendency, and problems arising from the hemangioma mass itself. A 20-month-old female was scheduled for cryosurgery of a hemangioma on the face. Massive bleeding from the tumor was easily induced even by slight contact. The hematologic examination revealed a low platelet count and anemia. Anesthesia was induced carefully by applying an adult anesthetic mask to avoid the large tumor mass on the face and maintained with halothane and nitrous oxide/oxygen. Additional doses of prednisolone were administered before and during anesthesia to compensate for possible adrenal insufficiency due to steroid therapy which she had been receiving. Neither excessive bleeding nor any other particular complications occurred during anesthesia and surgery, and the postoperative course was also uneventful.
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PMID:Anesthetic management of a patient with Kasabach-Merritt syndrome. 347 74

We report the case of a 35-year-old patient who presented with acute adrenal insufficiency, then developed fever, hypoalbuminuria, anasarca, thrombocytopaenia and anaemia. Lymphadenopathy appeared later with microscopic features typical of Castleman's disease. Clinical remission followed treatment with intravenous immunoglobulin. Circulating interleukin-6 levels were elevated initially but were normal after immunoglobulin therapy. We surmise that high circulating levels of interleukin-6 (and ACTH) may have induced haemorrhagic necrosis of the adrenal glands and accounted for the constitutional symptoms.
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PMID:Acute adrenal insufficiency: a new presentation of Castleman's disease. 760 51

Polyglandular autoimmune syndrome (PGA's) are defined as the coexistence of one or several primary endocrine gland autoimmune insufficiencies, possibly associated with other immunological pathologies. We present the case of a female patient suffering from a primary thyroid failure associated with Biermer anemia and hypophysitis with secondary adrenal insufficiency. We then describe the PGA's, focusing on their interest to the pediatrician, internist, and primary case physician. The three types of polyglandular syndromes, types I and II with adrenal insufficiency, and type III without it, are discussed. (Classification of Neufeld et al.).
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PMID:[Polyglandular autoimmune syndrome]. 827 15

Neurofibromatosis type 1 is the most common autosomal dominant inheritable disease, which is often associated with secondary forms of hypertension and with tumors of neuroectodermal origin. The authors present the results of evaluation of 60 members of 3 families. Of the 60 family members, 13 subjects had symptoms of neurofibromatosis type 1 disease, of which 7 subjects were evaluated. The case histories of patients are discussed: (1) An incidentally discovered adrenal tumor was proved to be a pheochromocytoma. (2) Because of complaints similar to thyrotoxicosis, thyrostatic drugs were administered for years without effect and, finally, an adrenal phaeochromocytoma was diagnosed after the presence of neurofibromatosis was established. (3) Preeclamptic pregnancy of a young primigravida complicated with severe HELLP syndrome (hemolysis-elevated liver enzymes-low platelet count) led to thorough evaluation which revealed renal artery stenosis. In this patient, percutaneous renal artery angioplasty resulted in a complete cessation of hypertension. (4) Glucocortocoid replacement therapy in a patient with neurofibromatosis type 1 resulted in a complete normalization of both secondary adrenal insufficiency and a previously unexplained iron-refractor iron-deficient anemia. The case histories of the patients demonstrate a lack of in-depth knowledge of neurofibromatosis in clinical practice. A regular follow-up of neurofibromatosis patients is suggested in specialized health centers.
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PMID:[Endocrinologic complications of neurofibromatosis type 1]. 899 16

A 64-year-old female referred to our hospital because of severe anemia. Peripheral blood examination showed macrocytic anemia; red blood cell count was 1.49 x 10(6)/microliters, hemoglobin concentration was 5.6 g/dl, hematocrit was 16.1% and MCV was 108 fl. Serum VB 12 level was significantly low as 58 pg/ml. Upper gastrointestinal examination disclosed chronic atrophic gastritis. Anti-intrinsic factor and anti-parietal cell antibodies were detected in the serum and Schilling's test was positive. Thus a diagnosis of pernicious anemia was made. Though the serum free T 3 and free T 4 levels were in normal ranges, the elevated serum TSH and positive tests for anti-microsome and anti-thyroglobulin antibodies indicated that the patient had chronic thyroiditis. Then other endocrinological examinations were performed. Low level of urinary 17-OHCS and a hypo-reactive pattern of rapid ACTH test led to a diagnosis of latent adrenal insufficiency. This case could be categorized into polyglandular autoimmune syndrome.
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PMID:[Pernicious anemia associated with chronic thyroiditis and suspected latent adrenal insufficiency]. 939 8

The case of a 21-year-old woman with findings consistent with Costello syndrome (CS) is reported. Most previously reported cases of CS were in young children. In addition to the classic features, the patient had endocrine disturbances including secondary amenorrhea, goiter, and adrenal insufficiency. This last abnormality may be the cause of the hypoglycemic episodes seen in CS. Osteoporosis and anemia were additional features. This case provides new information on the endocrine features and prognosis of CS.
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PMID:A case of Costello syndrome with endocrine features. 983 70

Usual causes of intolerance to thyroxine sodium include coronary artery disease, advanced age, untreated adrenal insufficiency, and severe hypothyroidism. We describe 4 patients with iron deficiency anemia and primary hypothyroidism. After treatment with thyroxine sodium, these patients developed palpitations and feelings of restlessness, which necessitated discontinuation of the thyroid hormone. After the anemia was treated with ferrous sulfate for 4 to 7 weeks, they were able to tolerate thyroxine sodium therapy. Iron deficiency anemia coexisting with primary hypothyroidism results in a hyperadrenergic state. In such patients, we postulate that thyroid hormone administration causes palpitations, nervousness, and feelings of restlessness. Correction of any existing pronounced anemia in hypothyroid patients who are intolerant to thyroxine sodium therapy may result in tolerance to this agent.
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PMID:Anemia: a cause of intolerance to thyroxine sodium. 1068 60

Even though effective chemotherapeutic regimens are available for treatment of tuberculosis (TB), disseminated tuberculosis (DT) continues to be a challenge to physicians. DT represents the unchecked haematogenous dissemination of Mycobacterium tuberculosis. It has been reported that 1.3% of all TB cases are classified as DT. Patients with DT present with a febrile illness of 2 to 4 months' duration. Organomegaly affecting liver, spleen and lymph nodes can be seen in DT. The radiological findings of DT associated with HIV infection are similar to those seen in HIV-seronegative patients. The value of high resolution computed tomography in DT is to demonstrate miliary pattern when chest radiographic findings are atypical or even normal. DT patients may have a mild normochromic anaemia with a normal white blood cell count. Leukaemoid reaction can occur in DT, but pancytopenia is rare. Pulmonary function studies show a mild restrictive ventilatory defect with diffusion defect in cases of pulmonary miliary tuberculosis. Treatment of DT is same as that for pulmonary tuberculosis. Replacement treatment with corticosteroids should be given in tuberculosis patients with adrenal insufficiency. The overall mortality from DT is nearly 20%.
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PMID:Disseminated tuberculosis. 1101 63


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