Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002871 (anemia)
 52,094 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between 1989 and 1992, 22 Bernese mountain dogs (18 females and four males) aged between two and seven years, which had been suffering for some weeks from weight loss, anorexia, apathy, vomiting, polydipsia and polyuria, were examined. All of them had high blood urea nitrogen and serum creatinine concentrations, and many had hyperphosphataemia, hypercholesterolaemia, hypoproteinaemia and nonregenerative anaemia. All the dogs had very high protein: creatinine ratios in the urine, and macroproteinuria was identified by sodium dodecyl sulphate gel electrophoresis. The immunofluorescent titres against Borrelia burgdorferi, measured in 19 of the dogs, ranged between 256 and 32,768. In all cases, membrano-proliferative glomerulonephritis with concomitant interstitial nephritis was diagnosed. From an analysis of the dogs' pedigree it was concluded that the glomerulonephritis of these Bernese mountain dogs was inherited as an autosomal recessive trait and that its expression was influenced by a second gene locus with a sex-linked dominance exchange.
Vet Rec 1994 Apr 16
PMID:A new familial glomerulonephropathy in Bernese mountain dogs. 803 71

A study was conducted among children under 12 years of age admitted to a rural district hospital in western Kenya to evaluate the use of blood transfusions, identify risk factors for severe anemia, and determine when transfusion improves survival of severely anemic children. A total of 2433 children were admitted to the pediatric ward during the 12-month study period; 29% (684) had severe anemia (hemoglobin [Hb] 5.0 g/dl) and 20% (483) received blood transfusions. Among children admitted with Hb 5.0 g/dl, 19% (124/663) had a history of prior transfusion, compared with only 6% (94/1607) with Hb 5.0 g/dl. The fatality rate of all children with Hb 5.0 g/dl was 18%, compared with 8% among children with Hb 5.0 g/dl. Among all children who died during hospitalization, 48% had a Hb 5.0 g/dl at the time of admission. Children younger than 3 years old accounted for 92% of admissions with Hb 5.0 g/dl, 87% of all pediatric deaths, and 92% of all pediatric transfusions. Age under 3 years and malaria parasitemia were associated with severe anemia. 88% (424) of transfusions were given to children with Hb 5.0 g/dl. Only 25% (120) of transfused children received blood on the date of admission, while 34% (161) were transfused the day after admission, and 41% (199) were transfused 2 or more days after admission. Among children with Hb 5.0 g/dl, 40% (274/683) were not transfused. If transfusions had been given only within the first 2 days of admission to children with respiratory distress and Hb 5.0 g/dl, the frequency of transfusion would have been reduced by 55% without increasing mortality. Prevention and effective treatment of the causes of anemia (such as malaria), targeted to children under 3 years of age, are critically needed to limit pediatric anemia, blood transfusion, and anemia-associated mortality.
Wkly Epidemiol Rec 1994 Mar 11
PMID:Global programme on AIDS. A study on the effect of blood transfusion on survival among children in a Kenyan hospital. 819 7

We report a familial recombination of a pericentric inversion of chromosome 10 resulting in 2 affected relatives who had 10p trisomy and 10q monosomy with the karyotypic abnormality designated rec(10) dup p,inv(10) (p11.2q26). Both of these individuals had the typical characteristics of 10p trisomy, however, at birth the proposita had mild facial anomalies suggesting that the distinct facial characteristics may be of postnatal onset in some cases. In addition, the proposita had gastroesophageal reflux causing severe anemia. The phenotype of our patients is compared to 41 patients with 10p trisomy reported in the literature.
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PMID:Familial 10p trisomy resulting from a maternal pericentric inversion. 820 87

Of 105 dogs examined at a veterinary hospital in Harare, Zimbabwe, 52 per cent had antibodies reactive with Ehrlichia canis in indirect fluorescent antibody tests, 26 per cent had Babesia canis parasites in peripheral blood smears and 17 per cent had both infections. None of the dogs with serological evidence of ehrlichiosis had typical E canis morulae detectable in blood smears. The infections were regarded as incidental findings not readily related to the reasons for examination in 46 per cent of the dogs with antibodies to E canis and 17 per cent of the dogs with both infections. The most common laboratory abnormalities were anaemia and thrombocytopenia and the prevalence and severity of these in concurrent infections were intermediate to those found in individual infections. There were no pathognomonic clinical signs or laboratory abnormalities which could be used to distinguish between individual and concurrent infections. However, there was a significantly higher prevalence of non-regenerative anaemia in dogs with antibodies to E canis than in dogs with both infections. The prevalence of thrombocytopenia was significantly higher in dogs with babesiosis than in dogs with antibodies to E canis and the prevalence of hyperglobulinaemia was significantly higher in dogs with both infections than in dogs with antibodies to E canis.
Vet Rec 1993 Oct 02
PMID:Infections with Babesia canis and Ehrlichia canis in dogs in Zimbabwe. 823 78

A four-month-old calf had a clinical history of pyrexia, anaemia, weight loss and behavioural abnormality. Clinical examination revealed evidence of regenerative anaemia and a lymphocytosis which was characterised by a relatively large B cell population. The calf deteriorated clinically while under observation and its prescapular and prefemoral lymph nodes became enlarged. Examination of a blood smear revealed the presence of a large number of circulating Trypanasoma theileri. Serological examination showed the presence of the invariant, stage-specific, trypanosome surface antigen, ISG70 and antibodies against ISG70. ISG70 was first identified in the bloodstream forms of Trypanosoma brucei and has not previously been found in T theileri. Clinical recovery was associated with an increase in packed cell volume, a decrease in the levels of circulating anti-ISG70 antibodies and the complete disappearance of circulating ISG70.
Vet Rec 1993 Jun 26
PMID:Clinical disease associated with Trypanosoma theileri infection in a calf in Ireland. 836 71

Twenty-four foals were confirmed to be infected with Rhodococcus equi on a private stud in Zimbabwe over a two-year period. Six mares had foals which were affected in each of the two years. All the foals were febrile and early cases were detected by this pyrexia. Bronchopneumonia was only clinically detectable in advanced cases. In spite of energetic hygiene measures relating to pasture and housing management, the incidence was higher in the second year (23 per cent of foals born) than in the first (15 per cent of foals born). The mean age of the foals was significantly greater in the second year. The immunological status of some of the foals was obtained from zinc sulphate turbidity tests performed at 24 hours old and all the affected foals so tested were considered to have had effective colostral transfer. Clinically, affected foals showed pyrexia, tachypnoea and tachycardia and many had a scanty purulent nasal discharge. Only one animal had diarrhoea which was attributed to enteric infection with R equi. Diagnosis was confirmed by clinical examination, culture of the organism from tracheal aspirates and thoracic radiography and was supported by significant elevations of plasma fibrinogen and platelet and neutrophil counts in all cases. Anaemia was not a major finding in any case. Rifampicin and erythromycin were administered per os and weight-related doses were continued until plasma fibrinogen and the absolute neutrophil and platelet counts had been persistently normal for two weeks. Supportive radiography was obtained in some cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Vet Rec 1993 Jan 23
PMID:Rhodococcus equi infection in foals: a report of an outbreak on a thoroughbred stud in Zimbabwe. 843 46

A dog whose major clinical signs suggested a coagulopathy, is described. The dog had a history of bleeding episodes and had a severe regenerative anaemia. By using specific factor assays, the coagulopathy was found to be due to a consumptive intravascular process that resembled chronic disseminated intravascular coagulation. Subsequent investigations identified Angiostrongylus vasorum as the cause.
Vet Rec 1996 Apr 13
PMID:Role of chronic disseminated intravascular coagulation in a case of canine angiostrongylosis. 873 63

Eperythrozoon suis infection was identified in a pig herd during an investigation into anaemia and low viability in newborn piglets and severe regenerative macrocytic anaemia in older piglets. The organisms were identified in the erythrocytes of piglets a few days old. Extensive investigations failed to detect other causes of the anaemia and low viability. There was no response to parenteral iron administration alone but the piglets' viability and anaemia responded to the administration of tetracyclines. This is the first report of E suis infection in Northern Ireland.
Vet Rec 1997 Feb 08
PMID:Anaemia and low viability in piglets infected with Eperythrozoon suis. 905 Jan 75

A study of the effects of iron dextran supplementation on anaemia in indoor lambs was carried out on one commercial flock of 525 lambs from January to June 1993. The lambs were randomly allocated into two groups, one of which was given a parenteral injection of 300 mg iron dextran and the other was left untreated. Blood was collected from 22 12-day-old lambs and 106 24-day-old lambs, in each case half treated and half untreated. The supplemented lambs had significantly improved haematological values than the unsupplemented lambs. There were also significant differences in the total serum iron concentration, the unsaturated iron binding capacity and the percentage serum saturation with iron between the treated and untreated lambs. At 12 days, the untreated lambs had a total serum iron below the accepted normal range for sheep whereas the treated lambs had values within the normal range. At weaning, lambs injected with iron dextran were significantly heavier (1.0 kg) than those not injected. The daily liveweight gain to slaughter was greater and the proportion of deaths was lower in the treated lambs but these differences were not statistically significant.
Vet Rec 1997 Mar 01
PMID:Preliminary study of the effect of iron dextran on a non-regenerative anaemia of housed lambs. 907 16

Severe fasting hypertriglyceridaemia (5 to 126 mmol/litre) and anaemia (packed cell volume < 11 per cent) was observed in 12 litters of kittens around the time of weaning; the entire litter was usually affected, with significant mortality. Lipid analysis revealed marked increases in chylomicrons and moderate increases in very low density lipoproteins. Supportive measures for the treatment of anaemia and weaning on to a low fat diet resulted in rapid resolution of the clinical signs, anaemia and hypertriglyceridaemia. On recovery, plasma was collected from kittens from five of the affected litters, plus a number of closely related cats and unrelated cats living in the same environment. The lipoprotein lipase (LPL) activity was mildly but significantly lower in the previously affected kittens, their parents and unaffected siblings, than in the unrelated cats. The cats had normal apolipoprotein C-II function, normal heparin binding activity and no evidence of a circulating inhibitor to LPL. They did not have the LPL gene mutation reported previously in LPL-deficient cats from New Zealand.
Vet Rec 1997 Apr 05
PMID:Transient hyperlipidaemia and anaemia in kittens. 913 18


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