Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ALS 0.176
SOD1 0.071
TDP-43 0.039
C9orf72 0.021
superoxide dismutase 1 0.017
TARDBP 0.012
FUS 0.012
Cu/Zn superoxide dismutase 0.010
TAR DNA-binding protein 43 0.008
FTD 0.007
FALS 0.004
ALS2 0.003
chromosome 9 open reading frame 72 0.003
UBQLN2 0.003
FUS protein 0.002
MLR 0.002
VAPB 0.002
vesicle-associated membrane protein-associated protein B 0.002
optineurin 0.002
alsin 0.002
DNA-binding protein 0.002
TLS 0.001
PDC 0.001
CHCHD10 0.001
superoxide dismutase 0.001
ATXN2 0.001
OPTN 0.001
axonal 0.001
TAF15 0.001
SMCR8 0.001
MATR3 0.001
ALS4 0.001
VCP 0.001
fus 0.001
ubiquitin 0.001
WDR41 0.001
Optineurin 0.001
prion 0.001
GLT-1 0.001
spinocerebellar ataxia type 2 0.001
senataxin 0.000
Superoxide dismutase 1 0.000
ubiquilin 0.000
PFN1 0.000
SOD 0.000
hnRNPA1 0.000
RNA-binding protein 0.000
ZNF512B 0.000
CHMP2B 0.000
p62 0.000
glutamate transporter 0.000
DNA binding protein 0.000
NEK1 0.000
SETX 0.000
GLT1 0.000
Dsk2 0.000
profilin 1 0.000
TUBA4A 0.000
NF-H 0.000
GRN 0.000
CCNF 0.000
DCTN1 0.000
FLJ10986 0.000
amyloid precursor protein 0.000
progranulin 0.000
Transcription factor IIIA 0.000
angiogenin 0.000
KIFAP3 0.000
BLS 0.000
RNA binding protein 0.000
peripherin 0.000
FIG4 0.000
LMN 0.000
ALS2 protein 0.000
Angiogenin 0.000
tau protein 0.000
proteasome 0.000
synuclein 0.000
UND 0.000
ataxin 2 0.000
more...
Disease
amyotrophic lateral sclerosis 1.000
motor neuron disease 0.024
FUS 0.012
primary lateral sclerosis 0.005
FTLD 0.005
Huntington's disease 0.005
FALS 0.004
Alzheimer's disease 0.004
dementia 0.004
Parkinson's disease 0.004
ALS2 0.003
progressive muscular atrophy 0.003
muscular atrophy 0.002
FTD-ALS 0.002
progressive bulbar palsy 0.001
ALS4 0.001
PDC 0.001
ALS8 0.001
multiple sclerosis 0.001
ALS6 0.001
parkinsonism 0.001
neurological disease 0.001
ALS7 0.001
Pick's disease 0.000
Frontotemporal dementia 0.000
ALS5 0.000
spastic paraplegia 0.000
respiratory failure 0.000
progressive supranuclear palsy 0.000
NEK1 0.000
degenerative disease 0.000
sarcoma 0.000
Charcot-Marie-Tooth disease 0.000
ALS3 0.000
dysphagia 0.000
BLS 0.000
IBMPFD 0.000
neuropathy 0.000
Familial motor neuron disease 0.000
neuromuscular disorder 0.000
myopathy 0.000
Friedreich's ataxia 0.000
stroke 0.000
SPG11 0.000
DM1 0.000
cognitive impairment 0.000
Fazio-Londe 0.000
Spinal muscular atrophy 0.000
muscular dystrophy 0.000
Supranuclear ophthalmoplegia 0.000
CNS diseases 0.000
Frontal lobe degeneration 0.000
Dementia with Lewy bodies 0.000
polyneuropathy 0.000
Hereditary canine spinal muscular atrophy 0.000
myasthenia gravis 0.000
hereditary motor and sensory neuropathy II 0.000
Genetic Brain Disorders 0.000
Kubisagari 0.000
Spinal cord degeneration 0.000
Other mental retardation 0.000
HMSNO 0.000
polio 0.000
PLSJ 0.000
pseudobulbar palsy 0.000
Brown-Vialetto-Van Laere syndrome 0.000
KNS 0.000
Creutzfeldt-Jakob disease 0.000
polymyositis 0.000
epilepsy 0.000
CMT2A2 0.000
Werdnig-Hoffmann disease 0.000
aphasia 0.000
SBMA 0.000
Kennedy syndrome 0.000
Sarcoma 0.000
postpolio syndrome 0.000
Sarcoma 0.000
Duchenne muscular dystrophy 0.000
wasting 0.000
more...
Symptom
weakness 0.001
fasciculation 0.001
dysarthria 0.000
spasticity 0.000
Flail 0.000
ataxia 0.000
Upper motor neuron signs 0.000
muscle cramps 0.000
amimia 0.000
Glossopharyngeal breathing 0.000
drooling 0.000
Diffuse inflammation 0.000
paresis 0.000
tremor 0.000
Upper back pain 0.000
Generalized fatigue 0.000
apathy 0.000
asthenia 0.000
paraparesis 0.000
Muscle fibrosis 0.000
Truncal ataxia 0.000
cerebellar ataxia 0.000
motor symptom 0.000
fatigue 0.000
Retropulsion 0.000
orthopnea 0.000
personality change 0.000
ophthalmoplegia 0.000
dyspnea 0.000
disturbed speech 0.000
Limb weakness 0.000
Diaphragmatic weakness 0.000
cough 0.000
dystonia 0.000
dyslalia 0.000
chorea 0.000
RNA marker 0.000
Pyramidal signs 0.000
Cramping 0.000
Bell's phenomenon 0.000
arm weakness 0.000
pain 0.000
pallor 0.000
aphagia 0.000
Spastic paraparesis 0.000
Excitability 0.000
clonus 0.000
functional recovery 0.000
aprosodia 0.000
hopelessness 0.000
bradykinesia 0.000
thinning 0.000
Severe diarrhea 0.000
Fatigability 0.000
Urge incontinence 0.000
frequent urination 0.000
skin pain 0.000
hypercapnia 0.000
Spastic 0.000
hoarseness 0.000
Motor dysfunction 0.000
myoclonus 0.000
seizures 0.000
inanition 0.000
twitching 0.000
respiratory problem 0.000
neurological disability 0.000
sleepiness 0.000
paresthesia 0.000
insomnia 0.000
collapse 0.000
memory loss 0.000
abnormal gait 0.000
starvation 0.000
clumsiness 0.000
leg cramps 0.000
acid regurgitation 0.000
anesthesia 0.000
nausea 0.000
Neurologic symptoms 0.000
more...
Drug
Rilutek 0.001
Xaliproden 0.000
CSF 0.000
TechneScan PYP 0.000
Tasmar 0.000
SR 57746A 0.000
Comtan 0.000
Protropin 0.000
Zydis 0.000
Frontal 0.000
Parkin 0.000
Parkin 0.000
5-Fluorouridine 0.000
Radicut 0.000
Mirapex 0.000
Y-700 0.000
p75 0.000
Requip 0.000
Azilect 0.000
Ranitidine 0.000
Mexitil 0.000
Myotrophin 0.000
Leucin 0.000
Requip 0.000
DM1 0.000
Sodium phenylbutyrate 0.000
Actos 0.000
Lubeluzole 0.000
Pramipexole 0.000
vitamin E 0.000
ACT 0.000
Actos 0.000
Quinate 0.000
Ocrelizumab 0.000
Imuran 0.000
Rapamune 0.000
Clemastine 0.000
Copaxone 0.000
ROS 0.000
Pramipexole 0.000
Creosote 0.000
lysine 0.000
Nabilone 0.000
AKM 0.000
Cytidine 0.000
MRC 0.000
ADM 0.000
Rasagiline 0.000
Levosimendan 0.000
Adapalene 0.000
Glutamic acid 0.000
CPR 0.000
Flavin 0.000
7-Nitroindazole 0.000
Vitamin E 0.000
Muse 0.000
Bosutinib 0.000
Modafinil 0.000
Quinine, 0.000
Adenosine deaminase 0.000
Rhubarb 0.000
RFP 0.000
Gabapentin 0.000
Febuxostat 0.000
ascorbate 0.000
PPA 0.000
Parlodel 0.000
ROC 0.000
Dilantin 0.000
Beta-2 0.000
BOTOX 0.000
Bexarotene 0.000
Vardenafil 0.000
Raloxifene 0.000
Botox 0.000
Daclizumab 0.000
Tocilizumab 0.000
beta-Galactosidase 0.000
Tranilast 0.000
Flavopiridol 0.000
more...
Enzyme
superoxide dismutase 0.001
proteasome 0.000
Alternating 0.000
acetolactate synthase 0.000
IKK 0.000
choline acetyltransferase 0.000
CCS 0.000
serine racemase 0.000
caspase-3 0.000
VOR 0.000
caspase-1 0.000
protein kinase 0.000
complex I 0.000
Thy1 0.000
mitogen-activated protein kinase 0.000
acetolactate decarboxylase 0.000
kinesin 0.000
MGAT 0.000
E-2 0.000
adenosine deaminase 0.000
adenosine deaminase 0.000
ubiquitin-protein ligase 0.000
GSK 0.000
galactosylhydroxylysyl glucosyltransferase 0.000
3-mercaptopyruvate sulfurtransferase 0.000
cytochrome oxidase 0.000
tubulin carboxypeptidase 0.000
cholesterol 25-hydroxylase 0.000
succinate dehydrogenase 0.000
prostate-specific membrane antigen 0.000
arginyltransferase 0.000
calcineurin 0.000
creatine kinase 0.000
superoxide reductase 0.000
RNase 0.000
phosphoinositide 5-phosphatase 0.000
ERK 0.000
glutathione peroxidase 0.000
RNase 0.000
acetylcholinesterase 0.000
hexosaminidase 0.000
NOS 0.000
ATPase 0.000
lactate dehydrogenase 0.000
choline dehydrogenase 0.000
aldehyde oxidase 0.000
CCS1 0.000
paraoxonase 0.000
catalase 0.000
glyceraldehyde-3-phosphate dehydrogenase 0.000
caspase-4 0.000
citrate synthase 0.000
glucocerebrosidase 0.000
AMP-activated protein kinase 0.000
phosphatidylinositol 3-kinase 0.000
2A protease 0.000
NADPH oxidase 0.000
ribonuclease 0.000
glutamine synthetase 0.000
branched-chain aminotransferase 0.000
caspase-4 0.000
paraoxonase 0.000
ribonuclease 0.000
ACS 0.000
ketohexokinase 0.000
methionine sulfoxide reductase 0.000
sulfhydryl oxidase 0.000
reverse transcriptase 0.000
NADPH oxidase 0.000
cathepsin B 0.000
MEK 0.000
caspase-6 0.000
ceruloplasmin 0.000
protein phosphatase 2A 0.000
PARP 0.000
caspase-6 0.000
TMT 0.000
sulfiredoxin 0.000
NADPH-diaphorase 0.000
peroxidase 0.000
more...
Compound
Riluzole 0.006
TDP 0.002
TAR 0.001
glutamate 0.001
Edaravone 0.000
AMPA 0.000
Glutamate 0.000
Cycasin 0.000
Neuronal 0.000
5-bromo-2-furamide 0.000
5-bromo-2-furamide 0.000
copper 0.000
alanine 0.000
Sarcosine 0.000
Ubiquitin 0.000
calcium 0.000
DNA 0.000
Talampanel 0.000
oxygen 0.000
Dec 0.000
zinc 0.000
IDPN 0.000
Glycoursodeoxycholate 0.000
24-Hydroxycholesterol 0.000
isoxazole 0.000
BSSG 0.000
CCS 0.000
2-thiophenecarboxamide 0.000
Creatine 0.000
NMDA 0.000
3-Nitrotyrosine 0.000
Chlorsulfuron 0.000
N-acetylaspartate 0.000
GM1 0.000
coenzyme Q10 0.000
glutamine 0.000
13-docosenoic acid 0.000
Nereistoxin 0.000
PSP 0.000
arginine 0.000
Thyronine 0.000
ethyl methylcarbamate 0.000
nitric oxide 0.000
8-Hydroxyguanine 0.000
NAAG 0.000
superoxide radical 0.000
Minocycline 0.000
ATP 0.000
Justicidin B 0.000
Primuline 0.000
proline 0.000
Clin 0.000
serine 0.000
3-hydroxyaspartic acid 0.000
3-hydroxyaspartic acid 0.000
3-hydroxyaspartic acid 0.000
3-hydroxyaspartic acid 0.000
cysteine 0.000
iron 0.000
Kaempferide 0.000
Securinine 0.000
aluminum 0.000
3-hydroxyaspartic acid 0.000
MPTP 0.000
Bikaverin 0.000
propionic acid 0.000
propionic acid 0.000
CNQX 0.000
3-hydroxyaspartic acid 0.000
Diaminopyridine 0.000
hydrogen 0.000
TRH 0.000
Coenzyme Q10 0.000
Agaritine 0.000
valine 0.000
D-Serine 0.000
5-methylisoxazole 0.000
2-nonenal 0.000
MEP 0.000
BNS 0.000
more...