Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DCTN1 protein 10.7
KIAA1600 10.7
KBTBD3 10.7
Neurofilament-light 10.7
zinc finger with KRAB and SCAN domains 3 10.7
Superoxide dismutase [Cu-Zn] 10.7
CXX1B 10.7
Praja 1 10.7
RNASE4 protein 10.7
GRIA4 protein 10.7
KIAA0693 10.7
Histone H2B type 1-K 10.7
FAM21C 10.7
Smith-Magenis syndrome chromosome region, candidate 8 10.7
glycosyltransferase 8 domain containing 1 10.7
killer cell immunoglobulin-like receptor KIR3DL2 10.7
UBQLN2 protein 10.7
ANXA11 protein 10.7
NT5C3L 10.7
SUNC1 10.7
neurofilament-3 10.7
ALS 10.7
CXorf64 10.7
SYNGR4 10.7
CELF5 10.7
ALS2CR1 10.7
KIAA1147 10.7
peroxisomal biogenesis factor 3 10.7
Histone H2A type 1 10.7
RAVER1 10.7
ZNF512B 10.5
TARDBP 10.5
WDR41 10.5
FALS 10.4
FLJ10986 10.4
UBQLN2 10.4
ALS2 protein 10.4
SMCR8 10.4
C9orf72 10.4
chromosome 9 open reading frame 72 10.3
FUS protein 10.3
RGNEF 10.3
vesicle-associated membrane protein-associated protein B 10.3
alsin 10.3
TAR DNA-binding protein 43 10.2
ALS2 10.2
CHCHD10 10.2
SFPQ protein 10.1
TDP-43 10.1
VAPB 9.9
SOD1 9.9
MATR3 9.8
KIFAP3 9.8
superoxide dismutase 1 9.7
NYD-SP29 9.7
Dipeptidyl-peptidase 6 9.7
NIPA1 protein 9.7
PURG-A 9.7
SCYL3 9.7
PLSJ 9.7
SYPL2 9.7
C7orf57 9.7
C20orf194 9.7
AAK1 protein 9.7
target of myb1 9.7
ORM2 protein 9.7
voltage-gated calcium channel alpha 1 subunit 9.7
OTU domain-containing protein 4 9.7
Dnchc1 9.7
interferon gamma-inducible protein 30 9.7
coiled-coil domain containing 3 9.7
DENND4A 9.7
protein phosphatase 1-delta 9.7
low density lipoprotein receptor-related protein 10 9.7
Reticulon 2 9.7
ALS2CR3 9.7
chromosome 6 open reading frame 10 9.7
ZFAND1 9.7
cytoplasmic dynein 1 heavy chain 1 9.7
myosin-IXa 9.7
more...
Disease
Familial motor neuron disease 10.7
HMSNO 10.7
Other mental retardation 10.7
hereditary motor and sensory neuropathy II 10.7
Genetic Brain Disorders 10.7
amyotrophic lateral sclerosis 10.7
Spinal cord degeneration 10.7
Kubisagari 10.7
ALS8 10.5
ALS6 10.5
ALS7 10.5
ALS4 10.3
FTD-ALS 10.2
ALS2 10.2
Supranuclear ophthalmoplegia 10.1
primary lateral sclerosis 10.1
ALS5 10.0
FALS 10.0
progressive bulbar palsy 9.9
Frontal lobe degeneration 9.7
CMT2A2 9.7
FTLD 9.7
progressive muscular atrophy 9.6
FUS 9.5
PLSJ 9.4
motor neuron disease 9.4
NEK1 9.2
Non-fluent aphasia 9.1
Amyotrophic lateral sclerosis with dementia 9.1
Upper motor neuron disease 9.1
Fazio-Londe 8.8
HMN V 8.7
protein metabolism disorder 8.7
Hereditary canine spinal muscular atrophy 8.7
HMN7B 8.7
IBMPFD 8.5
PIN-1 8.4
SCAR8 8.4
Dysprosody 8.4
CMT2B1 8.1
moria 8.1
KNS 8.0
Brown-Vialetto-Van Laere syndrome 8.0
Pick's disease with Pick bodies 8.0
PDC 8.0
ALS3 8.0
Parkinson-dementia complex of Guam 7.9
Diffuse cerebral atrophy 7.9
LCCS 7.9
Cervical spinal cord compression 7.9
Motor neuropathy 7.9
SPG10 7.8
Kennedy syndrome 7.8
Frontotemporal dementia 7.8
SPG11 7.8
Fluent Aphasia 7.7
Bulbar weakness 7.7
CMT2B2 7.5
Degenerative myelopathy 7.5
Affect lability 7.5
Pick's disease 7.5
SPG30 7.4
AOA2 7.4
BLS 7.3
Progressive Aphasia 7.3
SPG28 7.2
OPA2 7.2
SPG21 7.1
Spinal cord atrophy 7.1
Huntington's disease 7.1
postpolio syndrome 7.0
mild memory disturbance 7.0
SBMA 7.0
muscular atrophy 7.0
spastic paraplegia 6.9
SPG8 6.9
Multifocal motor neuropathy 6.9
CMT2F 6.8
carcinoma of the glottis 6.8
Giant axonal neuropathy 6.8
more...
Symptom
Upper motor neuron signs 9.1
Flail 9.1
Glossopharyngeal breathing 8.7
Diffuse inflammation 8.7
amimia 8.4
Generalized fatigue 8.1
Upper back pain 8.1
fasciculation 7.4
Truncal ataxia 7.4
Muscle fibrosis 7.4
Retropulsion 7.0
disturbed speech 6.7
Limb weakness 6.5
Diaphragmatic weakness 6.5
dyslalia 6.2
dysarthria 6.2
Pyramidal signs 6.1
RNA marker 6.1
Cramping 6.1
muscle cramps 5.8
Bell's phenomenon 5.7
drooling 5.7
Spastic paraparesis 5.7
aprosodia 5.3
motor symptom 5.3
spasticity 5.2
weakness 5.2
orthopnea 5.2
arm weakness 5.2
aphagia 5.1
personality change 5.0
Severe diarrhea 4.9
Fatigability 4.7
Excitability 4.7
Urge incontinence 4.7
skin pain 4.5
asthenia 4.4
Motor dysfunction 4.3
paraparesis 4.3
ataxia 4.3
frequent urination 4.3
Spastic 4.2
clonus 4.2
apathy 4.1
respiratory problem 4.0
paresis 4.0
cerebellar ataxia 3.9
inanition 3.9
ophthalmoplegia 3.8
chorea 3.8
leg cramps 3.5
pallor 3.5
acid regurgitation 3.3
hopelessness 3.2
bradykinesia 3.2
clumsiness 3.2
Neurologic symptoms 3.2
neurological disability 3.2
tremor 3.1
abnormal breathing 3.0
abnormal gait 2.9
loss of balance 2.9
dystonia 2.9
Respiratory symptoms 2.8
ACHE 2.8
rundown 2.7
twitching 2.7
auditory hallucination 2.7
athetosis 2.7
hoarseness 2.6
ataxic gait 2.6
hyperemesis 2.5
hypertonia 2.4
dysesthesia 2.4
thirsty 2.4
Psychiatric symptoms 2.4
myoclonus 2.3
limb pain 2.3
meningism 2.3
forgetfulness 2.3
more...
Drug
Rilutek 10.5
Tasmar 9.1
TechneScan PYP 9.1
Xaliproden 9.1
SR 57746A 8.1
Comtan 7.9
Protropin 7.4
Radicut 7.4
Zydis 7.4
Mirapex 7.2
Y-700 7.2
5-Fluorouridine 7.2
Requip 6.9
Mexitil 6.5
Requip 6.4
Azilect 6.4
Leucin 6.4
Myotrophin 6.3
Actos 5.9
Sodium phenylbutyrate 5.9
Lubeluzole 5.7
Actos 5.5
Quinate 5.4
Ocrelizumab 5.3
Rapamune 5.2
Clemastine 5.2
Imuran 5.1
Creosote 5.0
Nabilone 5.0
Pramipexole 5.0
AKM 4.9
Pramipexole 4.6
Parkin 4.5
Parkin 4.5
Frontal 4.5
Adapalene 4.4
Cytidine 4.4
Rasagiline 4.4
Copaxone 4.4
7-Nitroindazole 4.2
Muse 4.2
Ranitidine 4.2
Bosutinib 4.2
Quinine, 4.0
Levosimendan 4.0
Flavin 3.9
DM1 3.9
p75 3.8
Glutamic acid 3.7
Modafinil 3.7
Rhubarb 3.7
Febuxostat 3.5
Parlodel 3.5
ACT 3.4
Dilantin 3.4
Beta-2 3.3
BOTOX 3.3
Adenosine deaminase 3.3
Bexarotene 3.3
Vardenafil 3.3
CSF 3.2
Daclizumab 3.2
PPA 3.1
Tranilast 3.0
Flavopiridol 3.0
Botox 3.0
Olmesartan 3.0
Diamminedichloroplatinum 3.0
CPR 3.0
Tocilizumab 3.0
Tolvaptan 3.0
beta-Galactosidase 2.9
Parlodel 2.9
Gabapentin 2.9
CVA 2.8
ADM 2.8
Raloxifene 2.8
Thioridazine 2.8
RFP 2.8
Tubocurarine 2.8
more...
Enzyme
acetolactate synthase 6.1
MGAT 6.0
serine racemase 6.0
CCS 5.7
acetolactate decarboxylase 5.6
Alternating 5.6
galactosylhydroxylysyl glucosyltransferase 5.3
tubulin carboxypeptidase 5.3
cholesterol 25-hydroxylase 5.2
VOR 5.2
superoxide dismutase 5.2
arginyltransferase 5.1
phosphoinositide 5-phosphatase 4.8
3-mercaptopyruvate sulfurtransferase 4.8
superoxide reductase 4.8
IKK 4.5
choline dehydrogenase 4.4
E-2 4.4
CCS1 4.4
ubiquitin-protein ligase 4.2
Thy1 4.2
choline acetyltransferase 4.1
proteasome 4.1
ketohexokinase 4.0
2A protease 3.9
branched-chain aminotransferase 3.9
methionine sulfoxide reductase 3.8
caspase-4 3.8
sulfhydryl oxidase 3.8
sulfiredoxin 3.7
riboflavin kinase 3.7
caspase-4 3.6
guanidinoacetate methyltransferase 3.6
aldehyde oxidase 3.5
glycinamide ribonucleotide transformylase 3.5
cathepsin X 3.5
arachidonate 5-lipoxygenase 3.5
FADS 3.5
LIS 3.5
calpain 3 3.4
caspase-6 3.4
protein disulfide-isomerase 3.4
glycine amidinotransferase 3.4
prostate-specific membrane antigen 3.4
oxoglutarate dehydrogenase 3.4
caspase-6 3.3
NMT 3.3
oxaloacetate decarboxylase 3.3
pyroglutamate aminopeptidase 3.3
3'-phosphatase 3.3
caspase-11 3.3
CYP46A1 3.3
caspase-11 3.2
NAO 3.2
reductoisomerase 3.2
CYP27A1 3.2
nitrile hydratase 3.2
fructose-2,6-bisphosphatase 3.2
cathepsin H 3.2
caspase-1 3.2
nicotinamide phosphoribosyltransferase 3.2
SNO 3.1
kinesin 3.1
TMT 3.1
argininosuccinate lyase 3.0
adenosine deaminase 3.0
seryl-tRNA synthetase 3.0
adenosine deaminase 3.0
glucocerebrosidase 3.0
paraoxonase 3.0
Protein 2 3.0
alanyl-tRNA synthetase 3.0
glutathione synthetase 2.9
guanase 2.8
oxytocinase 2.8
complex I 2.8
GSK 2.8
3C protease 2.8
pantothenate kinase 2.8
SOR 2.7
more...
Compound
5-bromo-2-furamide 10.7
5-bromo-2-furamide 10.7
Riluzole 9.7
Cycasin 9.0
Glycoursodeoxycholate 8.7
TDP 8.3
Talampanel 8.2
24-Hydroxycholesterol 8.1
2-thiophenecarboxamide 8.1
BSSG 8.0
Chlorsulfuron 7.5
Nereistoxin 7.4
13-docosenoic acid 7.4
TAR 7.3
ethyl methylcarbamate 7.2
Thyronine 7.2
Edaravone 7.2
IDPN 7.2
Justicidin B 7.0
Primuline 7.0
3-hydroxyaspartic acid 6.9
3-hydroxyaspartic acid 6.9
3-hydroxyaspartic acid 6.9
3-hydroxyaspartic acid 6.9
Sarcosine 6.8
Securinine 6.8
3-Nitrotyrosine 6.8
Kaempferide 6.8
8-Hydroxyguanine 6.8
3-hydroxyaspartic acid 6.7
Bikaverin 6.6
Diaminopyridine 6.5
3-hydroxyaspartic acid 6.5
NAAG 6.5
Agaritine 6.4
C2H4O2 6.2
Cartap 6.1
BNS 6.0
1-methyl-1,2,3,6-tetrahydropyridine 5.8
2,5-cyclohexadien-1-one 5.7
4-fluorobenzoic acid 5.7
Rhynchophylline 5.6
CCS 5.6
Bisdemethoxycurcumin 5.5
Guanabenz 5.4
P-D 5.4
Methylcobalamin 5.3
Methylazoxymethanol 5.3
Clemastine 5.3
Acid Yellow 5.2
Lanthionine 5.2
D-Serine 5.2
1-octacosanol 5.2
reduced riboflavin 5.2
hydroxyacetic acid 5.2
Benzothiazole 5.2
1,4-cyclohexanedione 5.1
Creatine 5.1
Echinacoside 5.1
DNC 5.1
DNC 5.1
Erucic acid 5.0
S-sulfocysteine 5.0
Dextromethorphan 5.0
Ginsenoside Re 5.0
EOC 5.0
FUR 5.0
Ubiquitin 4.9
Glutamate 4.9
Anacardic acid 4.9
Purine nucleoside 4.9
Glucosylceramide 4.8
PSP 4.8
5,5-dimethyl-1,3-cyclohexanedione 4.8
Minocycline 4.7
Quinic acid 4.7
Ferrozine 4.7
AMPA 4.7
PYC 4.7
isoxazole 4.7
more...