Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
19,048 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein ALS 3355 SOD1 2379 Mol 1312 TDP-43 1163 Sep 1058 superoxide dismutase 933 axonal 835 ubiquitin 675 superoxide dismutase 1 650 FUS 508 C9orf72 502 Cu/Zn superoxide dismutase 488 SOD 408 FTD 375 endoplasmic reticulum 372 DNA-binding protein 356 prion 337 MLR 303 proteasome 290 fused 283 amyloid precursor protein 279 TARDBP 270 MRI 232 TAR DNA-binding protein 43 223 RNA-binding protein 188 ATP 187 p62 179 CSF 168 glial fibrillary acidic protein 154 cytokine 150 caspase-3 147 synuclein 133 tau protein 128 glutamate transporter 126 PDC 124 brain-derived neurotrophic factor 123 insulin 120 VCP 117 neurotrophic factor 114 GLT-1 111 TLS 111 DNA binding protein 107 NMR 102 optineurin 96 vascular endothelial growth factor 94 PDB 90 ALS2 87 FALS 86 RNA binding protein 83 glutamate receptor 79 She 79 tumor necrosis factor 79 progranulin 75 TNF 74 chromosome 9 open reading frame 72 73 Bcl-2 72 alpha-synuclein 71 NMDA receptor 70 p53 69 nuclear protein 68 OPTN 68 angiogenin 67 LC3 66 antioxidant enzyme 66 huntingtin 65 choline acetyltransferase 64 GABA 63 Pol 63 glial cell line-derived neurotrophic factor 63 nerve growth factor 63 X-linked 61 survival factor 61 UBQLN2 61 Nrf2 60 nitric oxide synthase 60 neurotrophin 60 CA1 60 lipopolysaccharide 60 NF-H 59 VAPB 58 more...

Disease amyotrophic lateral sclerosis 19048 Alzheimer's disease 2841 Parkinson's disease 2096 dementia 2015 motor neuron disease 1144 Huntington's disease 1119 multiple sclerosis 841 muscular atrophy 606 stroke 554 FUS 508 parkinsonism 445 cancer 355 respiratory failure 313 sarcoma 306 neurological disease 297 cognitive impairment 271 epilepsy 254 neuropathy 241 depression 231 dysphagia 206 FTLD 192 diabetes 177 schizophrenia 177 myopathy 161 ischemia 155 neuroblastoma 146 progressive supranuclear palsy 144 primary lateral sclerosis 140 degenerative disease 131 FALS 127 progressive muscular atrophy 125 PDC 124 spastic paraplegia 106 polyneuropathy 104 muscular dystrophy 102 myasthenia gravis 101 tumor 98 Charcot-Marie-Tooth disease 97 polio 94 DM1 92 HIV 89 ALS2 89 glaucoma 87 myelopathy 86 Pick's disease 85 autism 83 wasting 81 Duchenne muscular dystrophy 80 aphasia 78 malnutrition 74 Creutzfeldt-Jakob disease 71 encephalopathy 67 CNS diseases 67 Friedreich's ataxia 66 cerebral ischemia 64 Frontotemporal dementia 62 obesity 62 polymyositis 61 peripheral neuropathy 59 GSH 58 neuromuscular disorder 53 Down syndrome 51 West 49 immunodeficiency 49 PDB 48 Dementia with Lewy bodies 48 progressive bulbar palsy 47 encephalitis 46 PLS 44 hypertension 44 Spinal muscular atrophy 44 virus infection 43 FTD-ALS 41 breast cancer 40 Sarcoma 39 atherosclerosis 39 Sarcoma 39 IBM 38 psychosis 37 AIDS 37 more...

Symptom weakness 842 ataxia 189 pain 183 dysarthria 161 spasticity 146 fasciculation 133 fatigue 120 tremor 97 dyspnea 80 cough 66 seizures 59 paresis 55 anesthesia 49 apathy 42 dystonia 37 functional recovery 34 asthenia 33 paraparesis 33 cerebellar ataxia 33 muscle cramps 30 collapse 30 ophthalmoplegia 28 thinning 27 starvation 27 headache 22 nausea 22 drooling 21 sleepiness 20 hypercapnia 19 insomnia 18 respiratory distress 18 chorea 17 pallor 17 agitation 15 discomfort 14 constipation 13 myoclonus 13 hopelessness 13 bradykinesia 13 anorexia 13 discomfort 12 paresthesia 12 acidity 11 motor symptom 11 personality change 11 hoarseness 11 dizziness 10 memory loss 10 overweight 10 orthopnea 10 hypothermia 10 analgesia 9 numbness 9 exhaustion 9 clonus 8 twitching 8 splenomegaly 8 cachexia 8 Flail 7 diarrhea 7 shortness of breath 6 stridor 6 Excitability 5 hemiplegia 5 abnormal gait 5 spasm 5 exertional dyspnea 5 neurological disability 5 acute stress 5 lethargy 4 arm weakness 4 myalgia 4 vertigo 4 vomiting 4 aphagia 4 regurgitation 4 hypertonia 4 hypersomnia 3 nausea and vomiting 3 clumsiness 3 more...

Drug CSF 172 lysine 65 vitamin E 42 ROS 38 p75 32 Frontal 28 Parkin 26 Parkin 26 ascorbate 24 Ranitidine 17 caffeine 17 MRC 14 NADH 14 DM1 14 Asn 14 ACT 14 ADM 13 ROC 13 Rilutek 12 Vitamin E 11 MAP 10 IL-2 10 Cardiovasc 8 Glutathione 8 ABC 8 CPR 8 Monit 7 IFN-gamma 7 CTX 6 Growth hormone 6 Alliance 6 Leaf 6 FAD 5 ENT 5 RFP 5 Spectrum 5 TAT 5 G-CSF 5 EE2 4 Glutamic acid 4 pyridoxal phosphate 4 Pramipexole 4 EPA 4 Copaxone 4 Estrogens 4 Growth hormone 4 Ethanol 4 Gabapentin 4 CAM 4 Ginseng 4 Adenosine deaminase 4 Award 4 PPA 3 SR 57746A 3 Biopolymers 3 Levosimendan 3 Angiotensin II 3 Spectrum 3 TTC 3 Fluorescein 3 Cytidine 3 GEO 3 Itraconazole 3 citric acid 3 Methylene blue 3 Raloxifene 3 Modafinil 3 ICI 3 BoNT/A 3 Gel 3 Pramipexole 3 Flavin 3 Heme 3 Zydis 2 ETA 2 TiO2 2 Botox 2 nitroglycerin 2 THA 2 Rasagiline 2 more...

Enzyme superoxide dismutase 1250 proteasome 291 mitogen-activated protein kinase 121 protein kinase 120 caspase-3 112 ERK 77 IKK 67 choline acetyltransferase 65 ATPase 58 ACS 54 catalase 50 Alternating 46 peroxidase 44 acetylcholinesterase 39 lactate dehydrogenase 38 creatine kinase 37 protein kinase C 37 complex I 37 calcineurin 36 glutathione peroxidase 36 RNase 35 caspase-1 34 reverse transcriptase 33 RNA polymerase 31 RNase 30 cytochrome oxidase 29 GSK 28 acetolactate synthase 27 kinesin 26 adenosine deaminase 25 adenosine deaminase 25 succinate dehydrogenase 25 MEK 24 AMP-activated protein kinase 22 focal adhesion kinase 22 glutathione S-transferase 20 tyrosine hydroxylase 20 phosphatidylinositol 3-kinase 20 PARP 20 luciferase 20 NOS 19 NADPH oxidase 19 NADPH oxidase 19 P-glycoprotein 18 CCS 18 trypsin 18 alanine aminotransferase 17 NO synthase 16 glyceraldehyde-3-phosphate dehydrogenase 16 ribonuclease 15 ribonuclease 15 hexosaminidase 13 citrate synthase 13 monoamine oxidase 13 cdc2 13 glutamine synthetase 13 Thy1 13 pyruvate dehydrogenase 12 ceruloplasmin 12 AMPK 12 caspase-8 12 cholinesterase 12 serine racemase 11 alkaline phosphatase 11 cathepsin B 11 thrombin 11 prostate-specific membrane antigen 11 transglutaminase 11 caspase-9 11 APC 10 phospholipase C 10 AMPK 10 glyceraldehyde-3-phosphate dehydrogenase 10 beta-galactosidase 10 glutathione reductase 10 glyceraldehyde-3-phosphate dehydrogenase 10 ACE 10 glyceraldehyde-3-phosphate dehydrogenase 10 collagenase 10 NADPH-diaphorase 10 more...

Compound Dec 1298 glutamate 836 DNA 836 Clin 634 calcium 557 oxygen 555 copper 347 alanine 295 water 266 zinc 262 Riluzole 208 hydrogen 199 TAR 199 ATP 187 TDP 185 iron 180 sodium 177 arginine 172 nitric oxide 163 AMPA 151 glucose 150 cysteine 135 Neuronal 131 serine 129 Glutamate 117 tyrosine 104 glutamine 95 proline 91 His 88 NMDA 88 lysine 86 aluminum 79 threonine 77 TNF 74 potassium 73 nitrogen 72 phosphate 68 GABA 64 GSH 64 leucine 64 GSH 64 GABA 63 manganese 62 Gly 57 acetate 57 ACS 54 ACS 54 methionine 51 valine 50 H2O2 50 Ubiquitin 49 sulfate 49 GM1 48 tryptophan 48 tryptophan 45 mercury 45 Ile 42 selenium 42 tryptophan 42 tryptophan 42 galactose 41 superoxide radical 40 NAD 40 nicotinamide 39 isoxazole 39 glutamic acid 37 N-acetylaspartate 37 Asp 37 SDS 36 NAD 35 propionic acid 35 propionic acid 35 Phe 35 TRH 34 CO2 34 MPTP 33 salt 33 isoleucine 33 isoleucine 32 urea 30 more...

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