Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002736 (
amyotrophic lateral sclerosis
)
19,048
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
ALS
0.176
SOD1
0.071
TDP-43
0.039
C9orf72
0.021
superoxide dismutase 1
0.017
TARDBP
0.012
FUS
0.012
Cu/Zn superoxide dismutase
0.010
TAR DNA-binding protein 43
0.008
FTD
0.007
FALS
0.004
ALS2
0.003
chromosome 9 open reading frame 72
0.003
UBQLN2
0.003
FUS protein
0.002
MLR
0.002
VAPB
0.002
vesicle-associated membrane protein-associated protein B
0.002
optineurin
0.002
alsin
0.002
DNA-binding protein
0.002
TLS
0.001
PDC
0.001
CHCHD10
0.001
superoxide dismutase
0.001
ATXN2
0.001
OPTN
0.001
axonal
0.001
TAF15
0.001
SMCR8
0.001
MATR3
0.001
ALS4
0.001
VCP
0.001
fus
0.001
ubiquitin
0.001
WDR41
0.001
Optineurin
0.001
prion
0.001
GLT-1
0.001
spinocerebellar ataxia type 2
0.001
more...
Disease
amyotrophic lateral sclerosis
1.000
motor neuron disease
0.024
FUS
0.012
primary lateral sclerosis
0.005
FTLD
0.005
Huntington's disease
0.005
FALS
0.004
Alzheimer's disease
0.004
dementia
0.004
Parkinson's disease
0.004
ALS2
0.003
progressive muscular atrophy
0.003
muscular atrophy
0.002
FTD-ALS
0.002
progressive bulbar palsy
0.001
ALS4
0.001
PDC
0.001
ALS8
0.001
multiple sclerosis
0.001
ALS6
0.001
parkinsonism
0.001
neurological disease
0.001
ALS7
0.001
Pick's disease
0.000
Frontotemporal dementia
0.000
ALS5
0.000
spastic paraplegia
0.000
respiratory failure
0.000
progressive supranuclear palsy
0.000
NEK1
0.000
degenerative disease
0.000
sarcoma
0.000
Charcot-Marie-Tooth disease
0.000
ALS3
0.000
dysphagia
0.000
BLS
0.000
IBMPFD
0.000
neuropathy
0.000
Familial motor neuron disease
0.000
neuromuscular disorder
0.000
more...
Symptom
weakness
0.001
fasciculation
0.001
dysarthria
0.000
spasticity
0.000
Flail
0.000
ataxia
0.000
Upper motor neuron signs
0.000
muscle cramps
0.000
amimia
0.000
Glossopharyngeal breathing
0.000
drooling
0.000
Diffuse inflammation
0.000
paresis
0.000
tremor
0.000
Generalized fatigue
0.000
Upper back pain
0.000
apathy
0.000
asthenia
0.000
paraparesis
0.000
Truncal ataxia
0.000
Muscle fibrosis
0.000
cerebellar ataxia
0.000
motor symptom
0.000
fatigue
0.000
Retropulsion
0.000
orthopnea
0.000
personality change
0.000
ophthalmoplegia
0.000
dyspnea
0.000
disturbed speech
0.000
Limb weakness
0.000
Diaphragmatic weakness
0.000
cough
0.000
dystonia
0.000
dyslalia
0.000
chorea
0.000
Pyramidal signs
0.000
RNA marker
0.000
Cramping
0.000
Bell's phenomenon
0.000
more...
Drug
Rilutek
0.001
Xaliproden
0.000
CSF
0.000
SR 57746A
0.000
TechneScan PYP
0.000
Tasmar
0.000
Comtan
0.000
Zydis
0.000
Protropin
0.000
Frontal
0.000
Parkin
0.000
Parkin
0.000
5-Fluorouridine
0.000
Radicut
0.000
Y-700
0.000
Mirapex
0.000
p75
0.000
Requip
0.000
Azilect
0.000
Ranitidine
0.000
Mexitil
0.000
Myotrophin
0.000
Requip
0.000
Leucin
0.000
DM1
0.000
Sodium phenylbutyrate
0.000
Actos
0.000
Lubeluzole
0.000
Pramipexole
0.000
vitamin E
0.000
ACT
0.000
Actos
0.000
Quinate
0.000
Ocrelizumab
0.000
Imuran
0.000
Rapamune
0.000
Clemastine
0.000
Copaxone
0.000
ROS
0.000
Pramipexole
0.000
more...
Enzyme
superoxide dismutase
0.001
proteasome
0.000
Alternating
0.000
acetolactate synthase
0.000
IKK
0.000
choline acetyltransferase
0.000
CCS
0.000
serine racemase
0.000
caspase-3
0.000
VOR
0.000
caspase-1
0.000
protein kinase
0.000
complex I
0.000
Thy1
0.000
mitogen-activated protein kinase
0.000
acetolactate decarboxylase
0.000
kinesin
0.000
MGAT
0.000
E-2
0.000
adenosine deaminase
0.000
adenosine deaminase
0.000
ubiquitin-protein ligase
0.000
GSK
0.000
galactosylhydroxylysyl glucosyltransferase
0.000
3-mercaptopyruvate sulfurtransferase
0.000
cytochrome oxidase
0.000
tubulin carboxypeptidase
0.000
cholesterol 25-hydroxylase
0.000
succinate dehydrogenase
0.000
prostate-specific membrane antigen
0.000
arginyltransferase
0.000
calcineurin
0.000
creatine kinase
0.000
superoxide reductase
0.000
RNase
0.000
phosphoinositide 5-phosphatase
0.000
ERK
0.000
glutathione peroxidase
0.000
RNase
0.000
acetylcholinesterase
0.000
more...
Compound
Riluzole
0.006
TDP
0.002
TAR
0.001
glutamate
0.001
Edaravone
0.000
AMPA
0.000
Glutamate
0.000
Cycasin
0.000
Neuronal
0.000
5-bromo-2-furamide
0.000
5-bromo-2-furamide
0.000
copper
0.000
alanine
0.000
Sarcosine
0.000
Ubiquitin
0.000
calcium
0.000
DNA
0.000
Talampanel
0.000
oxygen
0.000
Dec
0.000
zinc
0.000
IDPN
0.000
Glycoursodeoxycholate
0.000
24-Hydroxycholesterol
0.000
isoxazole
0.000
BSSG
0.000
CCS
0.000
2-thiophenecarboxamide
0.000
Creatine
0.000
NMDA
0.000
3-Nitrotyrosine
0.000
Chlorsulfuron
0.000
N-acetylaspartate
0.000
GM1
0.000
coenzyme Q10
0.000
glutamine
0.000
13-docosenoic acid
0.000
Nereistoxin
0.000
PSP
0.000
arginine
0.000
more...