Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
19,048 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein ALS 3355 SOD1 2379 Mol 1312 TDP-43 1163 Sep 1058 superoxide dismutase 933 axonal 835 ubiquitin 675 superoxide dismutase 1 650 FUS 508 C9orf72 502 Cu/Zn superoxide dismutase 488 SOD 408 FTD 375 endoplasmic reticulum 372 DNA-binding protein 356 prion 337 MLR 303 proteasome 290 fused 283 amyloid precursor protein 279 TARDBP 270 MRI 232 TAR DNA-binding protein 43 223 RNA-binding protein 188 ATP 187 p62 179 CSF 168 glial fibrillary acidic protein 154 cytokine 150 caspase-3 147 synuclein 133 tau protein 128 glutamate transporter 126 PDC 124 brain-derived neurotrophic factor 123 insulin 120 VCP 117 neurotrophic factor 114 TLS 111 more...

Disease amyotrophic lateral sclerosis 19048 Alzheimer's disease 2841 Parkinson's disease 2096 dementia 2015 motor neuron disease 1144 Huntington's disease 1119 multiple sclerosis 841 muscular atrophy 606 stroke 554 FUS 508 parkinsonism 445 cancer 355 respiratory failure 313 sarcoma 306 neurological disease 297 cognitive impairment 271 epilepsy 254 neuropathy 241 depression 231 dysphagia 206 FTLD 192 diabetes 177 schizophrenia 177 myopathy 161 ischemia 155 neuroblastoma 146 progressive supranuclear palsy 144 primary lateral sclerosis 140 degenerative disease 131 FALS 127 progressive muscular atrophy 125 PDC 124 spastic paraplegia 106 polyneuropathy 104 muscular dystrophy 102 myasthenia gravis 101 tumor 98 Charcot-Marie-Tooth disease 97 polio 94 DM1 92 more...

Symptom weakness 842 ataxia 189 pain 183 dysarthria 161 spasticity 146 fasciculation 133 fatigue 120 tremor 97 dyspnea 80 cough 66 seizures 59 paresis 55 anesthesia 49 apathy 42 dystonia 37 functional recovery 34 asthenia 33 cerebellar ataxia 33 paraparesis 33 muscle cramps 30 collapse 30 ophthalmoplegia 28 starvation 27 thinning 27 headache 22 nausea 22 drooling 21 sleepiness 20 hypercapnia 19 insomnia 18 respiratory distress 18 pallor 17 chorea 17 agitation 15 discomfort 14 constipation 13 hopelessness 13 myoclonus 13 bradykinesia 13 anorexia 13 more...

Drug CSF 172 lysine 65 vitamin E 42 ROS 38 p75 32 Frontal 28 Parkin 26 Parkin 26 ascorbate 24 caffeine 17 Ranitidine 17 MRC 14 DM1 14 ACT 14 NADH 14 Asn 14 ROC 13 ADM 13 Rilutek 12 Vitamin E 11 MAP 10 IL-2 10 Cardiovasc 8 ABC 8 CPR 8 Glutathione 8 IFN-gamma 7 Monit 7 CTX 6 Alliance 6 Growth hormone 6 Leaf 6 FAD 5 RFP 5 G-CSF 5 TAT 5 ENT 5 Spectrum 5 EPA 4 Pramipexole 4 more...

Enzyme superoxide dismutase 1250 proteasome 291 mitogen-activated protein kinase 121 protein kinase 120 caspase-3 112 ERK 77 IKK 67 choline acetyltransferase 65 ATPase 58 ACS 54 catalase 50 Alternating 46 peroxidase 44 acetylcholinesterase 39 lactate dehydrogenase 38 protein kinase C 37 complex I 37 creatine kinase 37 calcineurin 36 glutathione peroxidase 36 RNase 35 caspase-1 34 reverse transcriptase 33 RNA polymerase 31 RNase 30 cytochrome oxidase 29 GSK 28 acetolactate synthase 27 kinesin 26 adenosine deaminase 25 adenosine deaminase 25 succinate dehydrogenase 25 MEK 24 focal adhesion kinase 22 AMP-activated protein kinase 22 glutathione S-transferase 20 PARP 20 phosphatidylinositol 3-kinase 20 tyrosine hydroxylase 20 luciferase 20 more...

Compound Dec 1298 glutamate 836 DNA 836 Clin 634 calcium 557 oxygen 555 copper 347 alanine 295 water 266 zinc 262 Riluzole 208 TAR 199 hydrogen 199 ATP 187 TDP 185 iron 180 sodium 177 arginine 172 nitric oxide 163 AMPA 151 glucose 150 cysteine 135 Neuronal 131 serine 129 Glutamate 117 tyrosine 104 glutamine 95 proline 91 His 88 NMDA 88 lysine 86 aluminum 79 threonine 77 TNF 74 potassium 73 nitrogen 72 phosphate 68 GABA 64 leucine 64 GSH 64 more...

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