Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
19,048 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein ALS 3355 SOD1 2379 Mol 1312 TDP-43 1163 Sep 1058 superoxide dismutase 933 axonal 835 ubiquitin 675 superoxide dismutase 1 650 FUS 508 C9orf72 502 Cu/Zn superoxide dismutase 488 SOD 408 FTD 375 endoplasmic reticulum 372 DNA-binding protein 356 prion 337 MLR 303 proteasome 290 fused 283 amyloid precursor protein 279 TARDBP 270 MRI 232 TAR DNA-binding protein 43 223 RNA-binding protein 188 ATP 187 p62 179 CSF 168 glial fibrillary acidic protein 154 cytokine 150 caspase-3 147 synuclein 133 tau protein 128 glutamate transporter 126 PDC 124 brain-derived neurotrophic factor 123 insulin 120 VCP 117 neurotrophic factor 114 GLT-1 111 TLS 111 DNA binding protein 107 NMR 102 optineurin 96 vascular endothelial growth factor 94 PDB 90 ALS2 87 FALS 86 RNA binding protein 83 glutamate receptor 79 tumor necrosis factor 79 She 79 progranulin 75 TNF 74 chromosome 9 open reading frame 72 73 Bcl-2 72 alpha-synuclein 71 NMDA receptor 70 p53 69 nuclear protein 68 OPTN 68 angiogenin 67 antioxidant enzyme 66 LC3 66 huntingtin 65 choline acetyltransferase 64 glial cell line-derived neurotrophic factor 63 Pol 63 GABA 63 nerve growth factor 63 X-linked 61 UBQLN2 61 survival factor 61 CA1 60 nitric oxide synthase 60 neurotrophin 60 Nrf2 60 lipopolysaccharide 60 NF-H 59 SMA 58 GSH 58 VAPB 58 fus 58 ribonucleoprotein 57 collagen 54 gut 54 ACS 54 Ubiquitin 54 histone 53 spinocerebellar ataxia type 2 52 dimeric 52 ATPase 52 inducible nitric oxide synthase 51 VEGF 51 ATXN2 50 FUS protein 49 IL-6 49 cytochrome c 48 peripherin 48 GLT1 48 threonine 48 IGF-I 47 polypeptide 47 GRN 47 insulin-like growth factor 46 P300 46 prion protein 46 TBK1 45 vesicle-associated membrane protein-associated protein B 44 PLS 44 androgen receptor 43 UTR 43 catalase 43 MAPK 42 p38 42 mTOR 42 glycoprotein 41 Optineurin 41 interferon 41 heat shock protein 41 alsin 41 NF-L 41 olfactory 40 ciliary neurotrophic factor 40 SMN 40 TAF15 39 HSP70 39 membrane protein 39 peroxidase 39 CD4 39 parvalbumin 39 ionotropic 38 ROS 38 dynactin 37 N-acetylaspartate 37 AR protein 37 glutathione peroxidase 36 GLAST 36 creatine kinase 35 hnRNPA1 35 ANG 35 histone deacetylase 35 NAD 35 heme oxygenase-1 34 cystatin C 34 calbindin 34 NF-M 33 Fas 33 acetylcholinesterase 33 neurofilament protein 33 chromosome 21 33 tyrosine kinase 33 SDS 33 calpain 33 TNF-alpha 33 asymmetrical 33 lactate dehydrogenase 32 ERK 32 PrP 32 erythroid 32 more...

Disease amyotrophic lateral sclerosis 19048 Alzheimer's disease 2841 Parkinson's disease 2096 dementia 2015 motor neuron disease 1144 Huntington's disease 1119 multiple sclerosis 841 muscular atrophy 606 stroke 554 FUS 508 parkinsonism 445 cancer 355 respiratory failure 313 sarcoma 306 neurological disease 297 cognitive impairment 271 epilepsy 254 neuropathy 241 depression 231 dysphagia 206 FTLD 192 schizophrenia 177 diabetes 177 myopathy 161 ischemia 155 neuroblastoma 146 progressive supranuclear palsy 144 primary lateral sclerosis 140 degenerative disease 131 FALS 127 progressive muscular atrophy 125 PDC 124 spastic paraplegia 106 polyneuropathy 104 muscular dystrophy 102 myasthenia gravis 101 tumor 98 Charcot-Marie-Tooth disease 97 polio 94 DM1 92 ALS2 89 HIV 89 glaucoma 87 myelopathy 86 Pick's disease 85 autism 83 wasting 81 Duchenne muscular dystrophy 80 aphasia 78 malnutrition 74 Creutzfeldt-Jakob disease 71 encephalopathy 67 CNS diseases 67 Friedreich's ataxia 66 cerebral ischemia 64 Frontotemporal dementia 62 obesity 62 polymyositis 61 peripheral neuropathy 59 GSH 58 neuromuscular disorder 53 Down syndrome 51 immunodeficiency 49 West 49 Dementia with Lewy bodies 48 PDB 48 progressive bulbar palsy 47 encephalitis 46 hypertension 44 PLS 44 Spinal muscular atrophy 44 virus infection 43 FTD-ALS 41 breast cancer 40 Sarcoma 39 atherosclerosis 39 Sarcoma 39 IBM 38 AIDS 37 psychosis 37 encephalomyelitis 36 bipolar disorder 35 brain atrophy 34 cold 33 leukemia 33 SDS 33 rheumatoid arthritis 32 plaque 32 apraxia 32 disinhibition 32 type 2 diabetes 32 liposarcoma 32 major depressive disorder 32 suicide 31 chronic pain 31 ATM 31 heart failure 29 fragile X syndrome 29 melanoma 28 spongiform encephalopathy 28 systemic lupus erythematosus 27 ALS4 27 chronic obstructive pulmonary disease 27 tetraplegia 27 sensory neuropathy 26 BLM 26 memory impairment 26 infectious diseases 26 autoimmune disease 26 BLS 26 asthma 26 cerebral palsy 26 diabetic neuropathy 25 PAF 25 cerebral infarction 24 aspiration pneumonia 24 cardiovascular disease 24 migraine 23 pneumonia 23 cytomegalovirus 23 sepsis 22 MRS 22 ALS8 21 ARF 21 amyloidosis 21 glioma 21 rare disease 21 sepsis 20 cystic fibrosis 20 cervical spondylosis 20 Crohn's disease 20 arthritis 19 chronic disease 19 ALS3 19 heart disease 19 retinitis pigmentosa 19 movement disorder 18 carcinoma 18 mental retardation 18 sleep apnea 18 gammopathy 18 ALS6 18 pseudobulbar palsy 18 mental retardation 18 fits 18 confusion 18 hyperglycemia 17 sleep disorders 17 lymphoma 17 myocardial infarction 17 PSP 17 worms 17 lupus 17 subacute sclerosing panencephalitis 17 cardiomyopathy 17 osteoporosis 17 Spinocerebellar ataxia 16 PNS 16 glioblastoma 16 dehydration 16 more...

Symptom weakness 842 ataxia 189 pain 183 dysarthria 161 spasticity 146 fasciculation 133 fatigue 120 tremor 97 dyspnea 80 cough 66 seizures 59 paresis 55 anesthesia 49 apathy 42 dystonia 37 functional recovery 34 asthenia 33 cerebellar ataxia 33 paraparesis 33 collapse 30 muscle cramps 30 ophthalmoplegia 28 thinning 27 starvation 27 nausea 22 headache 22 drooling 21 sleepiness 20 hypercapnia 19 insomnia 18 respiratory distress 18 chorea 17 pallor 17 agitation 15 discomfort 14 hopelessness 13 bradykinesia 13 anorexia 13 myoclonus 13 constipation 13 discomfort 12 paresthesia 12 hoarseness 11 acidity 11 motor symptom 11 personality change 11 memory loss 10 orthopnea 10 hypothermia 10 dizziness 10 overweight 10 numbness 9 exhaustion 9 analgesia 9 twitching 8 cachexia 8 clonus 8 splenomegaly 8 Flail 7 diarrhea 7 shortness of breath 6 stridor 6 abnormal gait 5 spasm 5 exertional dyspnea 5 hemiplegia 5 neurological disability 5 Excitability 5 acute stress 5 myalgia 4 vertigo 4 aphagia 4 lethargy 4 vomiting 4 regurgitation 4 arm weakness 4 hypertonia 4 hypersomnia 3 Mills 3 nausea and vomiting 3 ENT 3 chest pain 3 clumsiness 3 amimia 3 dysesthesia 3 low back pain 3 syncope 3 cancer pain 3 tinnitus 3 Ill 3 rundown 2 Neuropathic pain 2 shoulder pain 2 stigma 2 neuralgia 2 Bell's phenomenon 2 blepharospasm 2 Upper motor neuron signs 2 inanition 2 Respiratory symptoms 2 back pain 2 abdominal pain 2 snoring 2 incoordination 2 muscle stiffness 2 limb pain 2 frequent urination 2 ataxic gait 2 alexithymia 2 Depressive symptoms 2 Spastic 2 leg pain 2 forgetfulness 2 Glossopharyngeal breathing 2 hunger 2 anosmia 2 loss of balance 2 polyuria 2 Fluctuation 1 aprosodia 1 disturbed speech 1 facial pain 1 Upper back pain 1 rales 1 auditory hallucination 1 mental fatigue 1 sciatica 1 Truncal ataxia 1 erythema 1 tingling 1 sore throat 1 RNA marker 1 hyperoxia 1 Severe diarrhea 1 flushing 1 distraction 1 Muscle fibrosis 1 dyslalia 1 athetosis 1 Cramping 1 livedo 1 Motor dysfunction 1 Limb weakness 1 Pyramidal signs 1 lightheadedness 1 Neurologic symptoms 1 hypocapnia 1 chills 1 respiratory problem 1 arm pain 1 neck pain 1 hypotonia 1 nasal congestion 1 Spastic paraparesis 1 Welt 1 acid regurgitation 1 stomach pain 1 excessive sweating 1 Postoperative pain 1 Decreased activity 1 more...

Drug CSF 172 lysine 65 vitamin E 42 ROS 38 p75 32 Frontal 28 Parkin 26 Parkin 26 ascorbate 24 caffeine 17 Ranitidine 17 Asn 14 ACT 14 NADH 14 DM1 14 MRC 14 ADM 13 ROC 13 Rilutek 12 Vitamin E 11 MAP 10 IL-2 10 ABC 8 Cardiovasc 8 CPR 8 Glutathione 8 Monit 7 IFN-gamma 7 Leaf 6 CTX 6 Alliance 6 Growth hormone 6 RFP 5 ENT 5 Spectrum 5 TAT 5 G-CSF 5 FAD 5 Growth hormone 4 EPA 4 EE2 4 Pramipexole 4 Glutamic acid 4 Ginseng 4 CAM 4 Adenosine deaminase 4 Ethanol 4 Estrogens 4 Award 4 Copaxone 4 pyridoxal phosphate 4 Gabapentin 4 TTC 3 Itraconazole 3 Angiotensin II 3 GEO 3 Levosimendan 3 Flavin 3 Fluorescein 3 Gel 3 Spectrum 3 Methylene blue 3 citric acid 3 Modafinil 3 Cytidine 3 BoNT/A 3 Pramipexole 3 Biopolymers 3 SR 57746A 3 PPA 3 Raloxifene 3 ICI 3 Heme 3 nitroglycerin 2 THA 2 Myotrophin 2 TiO2 2 Zydis 2 Botox 2 Riboflavin 2 Rasagiline 2 Adenosine triphosphate 2 Arsenic trioxide 2 Dermatol 2 Protropin 2 Imuran 2 Singular 2 Glucagon 2 G418 2 Xaliproden 2 5-Fluorouridine 2 Tocilizumab 2 Alanine 2 ETS 2 9-THC 2 Indomethacin 2 Apomorphine 2 lactose 2 CVA 2 GHRP 2 CTX 2 CTX 2 Azilect 2 Vitamin B12 2 Paraffin 2 Kainic acid 2 beta-Galactosidase 2 ALA 2 TAK 2 ETA 2 CED 2 Actos 1 Guanidine 1 Thioridazine 1 PMPA 1 NH3 1 Fructose 1 Cibacron Blue 1 Retinoic acid 1 Diurnal 1 Doxycycline 1 DMSA 1 Quinate 1 DHT 1 7-Nitroindazole 1 AraC 1 Parlodel 1 Olmesartan 1 Vardenafil 1 CCL 1 EPI 1 SPP 1 Cimetidine 1 BH4 1 Ranolazine 1 TechneScan PYP 1 Mexitil 1 Check 1 Ranolazine 1 Lenalidomide 1 Bifidobacterium 1 EDR 1 Ezetimibe 1 Lubeluzole 1 Taxol 1 balanced salt solution 1 Mutagen 1 Requip 1 Dial 1 Histamine 1 Parlodel 1 Phenytoin 1 Filgrastim 1 DMI 1 Simvastatin 1 Nabilone 1 Rutin 1 Quinine, 1 AKM 1 DPA 1 more...

Enzyme superoxide dismutase 1250 proteasome 291 mitogen-activated protein kinase 121 protein kinase 120 caspase-3 112 ERK 77 IKK 67 choline acetyltransferase 65 ATPase 58 ACS 54 catalase 50 Alternating 46 peroxidase 44 acetylcholinesterase 39 lactate dehydrogenase 38 protein kinase C 37 complex I 37 creatine kinase 37 glutathione peroxidase 36 calcineurin 36 RNase 35 caspase-1 34 reverse transcriptase 33 RNA polymerase 31 RNase 30 cytochrome oxidase 29 GSK 28 acetolactate synthase 27 kinesin 26 succinate dehydrogenase 25 adenosine deaminase 25 adenosine deaminase 25 MEK 24 AMP-activated protein kinase 22 focal adhesion kinase 22 luciferase 20 glutathione S-transferase 20 PARP 20 phosphatidylinositol 3-kinase 20 tyrosine hydroxylase 20 NADPH oxidase 19 NADPH oxidase 19 NOS 19 trypsin 18 CCS 18 P-glycoprotein 18 alanine aminotransferase 17 glyceraldehyde-3-phosphate dehydrogenase 16 NO synthase 16 ribonuclease 15 ribonuclease 15 hexosaminidase 13 cdc2 13 monoamine oxidase 13 Thy1 13 glutamine synthetase 13 citrate synthase 13 caspase-8 12 pyruvate dehydrogenase 12 AMPK 12 cholinesterase 12 ceruloplasmin 12 serine racemase 11 alkaline phosphatase 11 prostate-specific membrane antigen 11 transglutaminase 11 cathepsin B 11 thrombin 11 caspase-9 11 glyceraldehyde-3-phosphate dehydrogenase 10 APC 10 beta-galactosidase 10 glutathione reductase 10 glyceraldehyde-3-phosphate dehydrogenase 10 phospholipase C 10 glyceraldehyde-3-phosphate dehydrogenase 10 NADPH-diaphorase 10 ACE 10 AMPK 10 collagenase 10 ubiquitin-protein ligase 9 cathepsin D 9 glyceraldehyde-3-phosphate dehydrogenase 9 NQO1 9 E-2 9 xanthine oxidase 9 protein phosphatase 2A 9 heme oxygenase 8 chitinase 8 paraoxonase 8 phosphodiesterase 8 paraoxonase 8 CPR 8 aspartate aminotransferase 8 MAP 7 arginase 7 glucocerebrosidase 7 histone acetyltransferase 7 phospholipase A2 7 VOR 7 CaMKII 7 PDK1 7 guanylate cyclase 7 proteinase K 6 adenylate cyclase 6 MIP 6 transcriptase 6 aldolase 6 aldehyde dehydrogenase 6 phosphoinositide 3-kinase 6 chymotrypsin 5 ATP synthase 5 DNA polymerase 5 endonuclease 5 MPP 5 pyruvate dehydrogenase 5 malate dehydrogenase 5 peroxiredoxin 5 enolase 5 glutaminase 5 pyruvate dehydrogenase 5 matrix metalloproteinase 9 5 matrix metalloproteinase 2 5 aldehyde oxidase 5 PAM 5 TAT 5 DNA methyltransferase 5 firefly luciferase 5 3-mercaptopyruvate sulfurtransferase 4 lysozyme 4 glutamate decarboxylase 4 PRE 4 botulinum neurotoxin 4 diaphorase 4 alcohol dehydrogenase 4 neuropathy target esterase 4 xanthine dehydrogenase 4 glutamate dehydrogenase 4 renin 4 glutamate dehydrogenase 4 glutamate dehydrogenase 4 MEKK1 4 TMT 4 succinic dehydrogenase 4 gamma-glutamylcysteine synthetase 3 lecithin:cholesterol acyltransferase 3 caspase-4 3 glycerol-3-phosphate dehydrogenase 3 gamma-glutamyl transpeptidase 3 neuraminidase 3 tissue plasminogen activator 3 plasmin 3 caspase-7 3 dihydrofolate reductase 3 methylenetetrahydrofolate reductase 3 caspase-6 3 glutathione synthetase 3 caspase-7 3 caspase-6 3 methylenetetrahydrofolate reductase 3 more...

Compound Dec 1298 glutamate 836 DNA 836 Clin 634 calcium 557 oxygen 555 copper 347 alanine 295 water 266 zinc 262 Riluzole 208 TAR 199 hydrogen 199 ATP 187 TDP 185 iron 180 sodium 177 arginine 172 nitric oxide 163 AMPA 151 glucose 150 cysteine 135 Neuronal 131 serine 129 Glutamate 117 tyrosine 104 glutamine 95 proline 91 His 88 NMDA 88 lysine 86 aluminum 79 threonine 77 TNF 74 potassium 73 nitrogen 72 phosphate 68 GSH 64 leucine 64 GSH 64 GABA 64 GABA 63 manganese 62 acetate 57 Gly 57 ACS 54 ACS 54 methionine 51 H2O2 50 valine 50 Ubiquitin 49 sulfate 49 GM1 48 tryptophan 48 mercury 45 tryptophan 45 tryptophan 42 selenium 42 Ile 42 tryptophan 42 galactose 41 superoxide radical 40 NAD 40 nicotinamide 39 isoxazole 39 glutamic acid 37 N-acetylaspartate 37 Asp 37 SDS 36 Phe 35 NAD 35 propionic acid 35 propionic acid 35 TRH 34 CO2 34 isoleucine 33 MPTP 33 salt 33 isoleucine 32 urea 30 ethanol 29 creatinine 28 Edaravone 28 coenzyme Q10 28 cAMP 27 cadmium 26 asparagine 26 ADP 26 PEG 25 retinoic acid 25 EMS 24 ADP 23 Insulin 23 ADP 23 homocysteine 23 AMP 22 TOF 22 Creatine 22 ADP-ribose 22 MTT 21 Cereb 20 silver 20 vitamin D 19 cGMP 19 gamma-aminobutyric acid 19 Cu(II) 19 L-DOPA 18 NADPH 18 PEG 18 CCS 18 NADPH 18 carbonate 18 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 17 caffeine 17 GTP 17 NO3 17 PSP 17 nitrate 17 isopropanol 16 cobalt 16 phosphocreatine 16 aspartic acid 16 2-nonenal 16 CNQX 16 MEK 16 Sarcosine 15 MIT 15 Minocycline 15 Lithium 15 MIT 15 aspartic acid 15 noradrenaline 15 bromide 14 N-acetylcysteine 14 Coenzyme Q10 14 5-HT 14 NADH 14 GM2 13 5-methylisoxazole 13 pyrimidine 13 cyanide 13 8-OHdG 13 pyrimidine 13 DAD 13 pyrrolidine 12 boron 12 Congo red 12 PAR 12 MEP 12 aldehyde 12 DAB 12 iodine 12 PGE2 12 MEP 12 TEM 12 Melatonin 12 Estrogen 12 aldehyde 12 FK506 11 dUTP 11 more...

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