Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002736 (
amyotrophic lateral sclerosis
)
19,048
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Animal model of the motor neuron disease
amyotrophic lateral sclerosis
(
ALS
), has implicated apoptotis in the neuronal degeneration evident in this disease. Mice showing
ALS
-like symptoms, as well as several human families with
ALS
, have a missense mutation in the gene coding for
DOD
-1. A defective enzyme enhances neuronal cell death by activating interleukin converting enzyme (ICE), an initia of apoptosis. The role of caspase-1 and caspase-3 in the apoptotic process is apparent and the use of the caspase inhibitor zVAD-fink demonstrated some promise in slowing neural death by apoptosis and prolonging life in mice with
ALS
-like symptoms. We discuss the possible mechanisms of caspase enzymes cascade activation and their central role in apoptosis and possibly in neural death.
...
PMID:[Role of caspases in neural degeneration in amyotrophic lateral sclerosis]. 1175 91
