Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Excitatory amino acids (EAA) have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). We have analyzed the distribution of the N-methyl-D-aspartate (NMDA) 1-(1-(2-thienyl)-cyclohexyl) piperidine (TCP), kainate and alpha-amino-3-hydroxy-5-methyl-4 isoxazole propionic acid (AMPA) quisqualate subtypes of EAA receptors using quantitative receptor autoradiography in the cervical and thoracic spinal cords of patients who have died with ALS, and of controls. We observed that in control spinal cords [3H]TCP/NMDA binding sites were located both in the ventral and dorsal horns with the highest densities being situated in lamina II. [3H]AMPA and [3H]kainate binding sites were present almost exclusively in the substantia gelatinosa of the dorsal horn. In ALS, the distribution of these 3 types of receptors was unchanged, but [3H]TCP/NMDA binding was decreased both in the dorsal and ventral horns. [3H]kainate binding was possibly decreased in substantia gelatinosa, of ALS cords. However, the limited sample size available for [3H]kainate binding did not permit statistical analysis. [3H]AMPA binding sites were unaltered in ALS. These results indicate that there is a preferential reduction in NMDA receptors in ALS. We suggest that should an excitotoxic mechanism be involved in the pathogenesis of ALS, then NMDA receptors may be the target of this effect.
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PMID:Alterations in spinal cord excitatory amino acid receptors in amyotrophic lateral sclerosis patients. 132 Apr 44

We developed a telemedicine instrument for home monitoring of subjects with respiratory diseases. The instrument directly measures blood oxygen saturation and pulse rate, but the most relevant aspect is that it also acts as digital recorder of parameters coming from several external instruments (spirometer, capnometer, NIBP device, etc.). It also connects to all pulmonary ventilators. The instrument main board includes five slots, which are used to insert the measuring boards (saturation and ventilation boards) and the interface boards (connecting the external instruments). Depending on patient's needs, only the proper measuring/interface boards are mounted, thus allowing maximum flexibility and cost saving. The instrument has several I/O units, and especially an internal modem for direct connection to the Internet through TCP/IP protocol. The instrument was extensively tested, and preliminary trials were performed over fifteen patients with amyotrophic lateral sclerosis.
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PMID:A telemedicine instrument for home monitoring of patients with chronic respiratory diseases. 1753 60