Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002736 (
amyotrophic lateral sclerosis
)
19,048
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of cytochrome P450 family was studied in patients with
amyotrophic lateral sclerosis
(
ALS
) in an attempt to evaluate the susceptibility to environmental substances including possible some neurotoxin. The metabolic ratio (MR) of
sparteine
sulfate was measured in 30 patients with
ALS
and 41 controls for the evaluation of the
sparteine
nitro (N)-oxidation with cytochrome P450 system. The population of phenotypes designed as extensive metabolisers (EMs), intermediate metabolisers (IMs), and poor metabolisers (PMs) for
sparteine
nitro (N)-oxidation was determined in each group. The lower MR (p less than 0.02) and higher frequency of EMs (p less than 0.05) were observed in
ALS
group, suggesting the excessive activity of N-oxidation with cytochrome P450 pathway in the
ALS
group. Especially in 15 patients with
ALS
age before 60, these tendencies were more remarkable with a significant lower MR (p less than 0.01) and extremely high frequency of EMs (p less than 0.005). The present study might suggest the possible participation of cytochrome P450 pathway in the development of
ALS
.
...
PMID:[The excessive activity of cytochrome P450 system in ALS--the metabolic ratio of sparteine]. 260 31
The activity of detoxication with the cytochrome P450 family of enzymes was studied in patients with
amyotrophic lateral sclerosis
(
ALS
). The metabolic ratio (MR) of
sparteine
sulphate was measured, and the population of phenotypes for
sparteine
nitro (N)-oxidation was determined in 30 patients with
ALS
and 41 controls for the assay of the
sparteine
N-oxidation by the cytochrome P450 enzymes. A lower MR and higher frequency of efficient metabolizers were observed in the
ALS
group, suggesting that there is efficient
sparteine
N-oxidation by cytochrome P450 pathways in
ALS
. This tendency was more marked in 15 patients with
ALS
aged under 60 years.
...
PMID:Polymorphic sparteine metabolism and amyotrophic lateral sclerosis. 261 89
