Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10(-8) M in angiotensin II and vasopressin and 10(-12) M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.
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PMID:Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo. 188 May 32

Using immunocytochemical methods, a severe loss of substance P, but not of enkephalin, cholecystokinin and serotonin containing fibers was observed in lamina IX of the spinal cords from 4 amyotrophic lateral sclerosis cases. Substance P-fibers were decreased before degeneration of motoneurons. They were normal in the remaining spinal gray matter.
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PMID:[Immunocytochemical study of the spinal distribution of substance P, enkephalins, cholecystokinin and serotonin in amyotrophic lateral sclerosis]. 242 58

We studied trophic effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on explanted cultures of ventral spinal cord from 13-14 old day rat embryo. There was a significant neurite promoting effect (NPE) in CCK-treated culture. The neuritic extension of ventral spinal cord exceeds control values 3.5-6.5 times. Otherwise, CGRP and NPE at any concentration. The possible mechanism of trophic effect of CCK on ventral spinal cord was briefly discussed. Our results may contribute to a therapeutic strategy for amyotrophic lateral sclerosis.
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PMID:Trophic effects of cholecystokinin and calcitonin gene-related peptide on ventral spinal cord in culture. 258 43

In 10 patients with amyotrophic lateral sclerosis (ALS), the CSF content of the neuropeptides vasoactive intestinal polypeptide (VIP) and cholecystokinin (CCK) as well as neural cell adhesion molecule (NCAM) was investigated. Compared with normal controls, no deviations were found in CCK or NCAM, while the values of VIP were significantly lower in ALS patients. This finding may reflect a loss of motor neurons.
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PMID:Neuropeptides and neural cell adhesion molecule (NCAM) in CSF from patients with ALS. 233 Aug 22