Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coffee is among the most widespread and healthiest beverages in the world. Coffee typically contains more caffeine than most other beverages, and is widely and frequently consumed. Thus, it contributes significantly to the overall caffeine consumption within the general population, particularly in adults. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health-promoting potential. Several lines of evidence have highlighted the beneficial effects towards several disease conditions including Type II diabetes, hepatitis C virus, hepatocellular carcinoma, nonalcoholic fatty liver disease and neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). The health-promoting properties of coffee are largely attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, and hydroxy hydroquinone. In this minireview, an attempt has been made to discuss the various evidences which are mainly derived from animal and cell models. Various mechanisms chiefly responsible for the beneficial effects of caffeine have also been briefly outlined. A short note on the undesirable effects of excessive coffee intakes is also presented.
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PMID:Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview. 2954 72

This work studied the use of three-dimensional voltammetry, particularly potential-time-current (E-t-i) data, on the development of electroanalytical methods. E-t-i data was obtained by taking chronoamperograms at potentials applied as pulses on a staircase waveform. By using this three-way kind of data and appropriate calibration algorithms, the possibility of achieving the second-order advantage was evaluated in the determination of ferrocyanide in the presence of the uncalibrated interference hydroquinone as a model system. The determination of acetaminophen in urine samples, where ascorbic acid and uric acid play the major roles as interferents was also studied. Parallel factor analysis (PARAFAC) and multivariate curve resolution alternating least-squares (MCR-ALS) were the algorithms employed in this work. Both algorithms successfully achieved the second-order advantage by correctly predicting the concentrations of the validation synthetic samples. Excellent predictions were obtained in the direct analysis of acetaminophen-spiked urine samples by E-t-i data and MCR-ALS.
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PMID:Three-dimensional voltammetry: Use of chronoamperometric E-t-i data to achieve second-order advantage. 3298 Jan 9