Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002736 (
amyotrophic lateral sclerosis
)
19,048
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Multiple resistance to acetolactate synthase (
ALS
, EC 2.2.1.6) and
5-enolpyruvylshikimate-3-phosphate synthase
(EPSPS,
EC 2.5.1.19
) inhibitor herbicides was studied in two populations of Conyza canadensis (RTG and STG) harvested in southern Spain. Dose-response and enzymatic activity studies for the
ALS
-inhibiting herbicides showed only cross-resistance to sulfonylureas group but not to the other
ALS
chemical groups in the RTG population. Regarding glyphosate, the dose-response studies showed that the RTG population was 11.8 times more resistant than the STG population, while the inhibition of EPSPS enzyme (I
50
) was similar for both populations. Altered/reduced absorption and translocation were the main resistance mechanisms for glyphosate but not for tribenuron-methyl. The metabolic studies to find differences in the amounts of metabolites between the two populations were carried out using thin layer chromatography (for tribenuron-methyl) and capillary electrophoresis (for glyphosate). Metabolites were significantly differed among the two populations for tribenuron-methyl but not for glyphosate. The sequencing of the target-site
ALS
gene from RTG plants revealed a single point mutation, Pro-197-Ala, that causes resistance to sulfonylurea herbicide in C. canadensis.
...
PMID:Physiological, biochemical and molecular bases of resistance to tribenuron-methyl and glyphosate in Conyza canadensis from olive groves in southern Spain. 3155 Jun 9
