Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0002736 (
amyotrophic lateral sclerosis
)
19,048
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
In recent years, the role of iron metabolism in
amyotrophic lateral sclerosis
(
ALS
) attracts more and more attention, and some studies have focused on the link between abnormal serum iron indicators and
ALS
. However, there are still big conflicts and inconsistency among different studies. To study the possible relationship between
ALS
and disturbed iron metabolism, we conducted this meta-analysis to conclude characteristics of abnormal serum iron-status indicator changes in
ALS
patients.
Methods:
We searched and screened main databases, including the PubMed, Embase, and Cochrane Library, to find studies related to the association between iron metabolism and
ALS
. The Revman 5.3 software was used to conduct meta-analysis.
Results:
Eleven studies were finally included in our analysis, composed of 1,599
ALS
patients and 1,255 controls in total. The results showed that the ferritin level was much higher in
ALS
patients compared with controls (MD = 70.48, 95% CI [51.41, 89.55],
p
< 0.00001), and the transferrin level was decreased in
ALS
patients compared with controls (
SMD
= -0.28, 95% CI [-0.38, -0.18],
p
< 0.00001), while there was no statistical difference in iron levels (
SMD
= 0.48, 95% CI [-0.07, 1.03],
p
= 0.09) between
ALS
patients and controls.
Conclusions:
Our research finds unusual changes in several indicators representing iron status, which suggest possible iron metabolism abnormalities in
ALS
patients. That may provide evidence for the link between iron metabolism and the pathogenesis of
ALS
.
...
PMID:Abnormal Serum Iron-Status Indicator Changes in Amyotrophic Lateral Sclerosis (ALS) Patients: A Meta-Analysis. 3250 36
