Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0002736 (amyotrophic lateral sclerosis)
 19,048 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The survival of C3H/He skin grafts can be prolonged on B6AF1 mice immunosuppressed with ALS by the injection of C3H/He marrow 1 week postgrafting. The precursor frequencies of donor-reactive CTL in the spleen and lymph nodes of ALS-treated, grafted mice given donor marrow were compared with CTL frequencies observed in ALS-treated, grafted controls. Spleens and nodes were removed from experimental and control mice on days +8, +14, +21, +58, and 1 year postgrafting, and used as effectors in the LDA. Donor-reactive CTL in the marrow-injected group remained suppressed as long as the recipients maintained their grafts. The frequency of CTL to third-party antigens was normal in mice bearing long-term C3H/He grafts. When marrow-injected mice rejected their grafts, the total donor-reactive CTL frequency returned to normal. In contrast, in ALS-treated controls that did not receive marrow, the total number of donor-reactive CTL returned to normal levels with recovery from the immunosuppressive effects of ALS. These results suggest that donor marrow suppresses the regeneration of donor-reactive CTL in the lymphoid tissues of ALS-treated mice, possibly by veto cell activity.
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PMID:The effect of injection of donor bone marrow on the frequency of donor-reactive CTL in antilymphocyte serum-treated, grafted mice. 141 58

The onset of a neurological disorder, such as amyotrophic lateral sclerosis (ALS), is so subtle that the symptoms are often overlooked, thereby ruling out the option of early detection of the abnormality. In the case of ALS, over 75% of the affected individuals often experience awkwardness when using their limbs, which alters their gait, i.e. stride and swing intervals. The aim of this work is to suitably represent the non-stationary characteristics of gait (fluctuations in stride and swing intervals) in order to facilitate discrimination between normal and ALS subjects. We define a simple-yet-representative feature vector space by exploiting the ambiguity domain (AD) to achieve efficient classification between healthy and pathological gait stride interval. The stride-to-stride fluctuations and the swing intervals of 16 healthy control and 13 ALS-affected subjects were analyzed. Three features that are representative of the gait signal characteristics were extracted from the AD-space and are fed to linear discriminant analysis and neural network classifiers, respectively. Overall, maximum accuracies of 89.2% (LDA) and 100% (NN) were obtained in classifying the ALS gait.
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PMID:Ambiguity domain-based identification of altered gait pattern in ALS disorder. 2273 99

More and more evidences indicate that diseases of the central nervous system have been seriously affected by fecal microbes. However, little work is done to explore interaction between amyotrophic lateral sclerosis (ALS) and fecal microbes. In the present study, high-throughput sequencing method was used to compare the intestinal microbial diversity of healthy people and ALS patients. The principal coordinate analysis, Venn and unweighted pair-group method using arithmetic averages (UPGMA) showed an obvious microbial changes between healthy people (group H) and ALS patients (group A), and the average ratios of Bacteroides, Faecalibacterium, Anaerostipes, Prevotella, Escherichia, and Lachnospira at genus level between ALS patients and healthy people were 0.78, 2.18, 3.41, 0.35, 0.79, and 13.07. Furthermore, the decreased Firmicutes/Bacteroidetes ratio at phylum level using LEfSE (LDA > 4.0), together with the significant increased genus Dorea (harmful microorganisms) and significant reduced genus Oscillibacter, Anaerostipes, Lachnospiraceae (beneficial microorganisms) in ALS patients, indicated that the imbalance in intestinal microflora constitution had a strong association with the pathogenesis of ALS.
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PMID:Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing. 2770 53

Brain-computer interfaces (BCIs) aim to restore independence to people with severe motor disabilities by allowing control of acursor on a computer screen or other effectors with neural activity. However, physiological and/or recording-related nonstationarities in neural signals can limit long-term decoding stability, and it would be tedious for users to pause use of the BCI whenever neural control degrades to perform decoder recalibration routines. We recently demonstrated that a kinematic decoder (i.e. a decoder that controls cursor movement) can be recalibrated using data acquired during practical point-and-click control of the BCI by retrospectively inferring users' intended movement directions based on their subsequent selections. Here, we extend these methods to allow the click decoder to also be recalibrated using data acquired during practical BCI use. We retrospectively labeled neural data patterns as corresponding to "click" during all time bins in which the click log-likelihood (decoded using linear discriminant analysis, or LDA) had been above the click threshold that was used during real-time neural control. We labeled as "non-click" those periods that the kinematic decoder's retrospective target inference (RTI) heuristics determined to be consistent with intended cursor movement. Once these neural activity patterns were labeled, the click decoder was calibrated using standard supervised classifier training methods. Combined with real-time bias correction and baseline firing rate tracking, this set of "retrospectively labeled" decoder calibration methods enabled a BrainGate participant with amyotrophic lateral sclerosis (T9) to type freely across 11 research sessions spanning 29days, maintaining high-performance neural control over cursor movement and click without needing to interrupt virtual keyboard use for explicit calibration tasks. By eliminating the need for tedious calibration tasks with prescribed targets and pre-specified click times, this approach advances the potential clinical utility of intracortical BCIs for individuals with severe motor disability.
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PMID:Retrospectively supervised click decoder calibration for self-calibrating point-and-click brain-computer interfaces. 2828 37